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  • Open Access

    ARTICLE

    miR-644a Inhibits Cellular Proliferation and Invasion via Suppression of CtBP1 in Gastric Cancer Cells

    Yingchao Li*, Xiaoni Yan*, Li Ren*, Yang Li

    Oncology Research, Vol.26, No.1, pp. 1-8, 2018, DOI:10.3727/096504016X14772410356982

    Abstract Epithelial–mesenchymal transition (EMT) is one of the most important mechanisms in the metastasis of various cancers, including gastric cancer (GC). In this study, we explored the putative significance of miR-644a and its role in EMT-mediated metastasis of GC. We first detected the expression of miR-644a in a cohort of 107 GC tissues using quantitative RT-PCR. The expression of miR-644a was suppressed in GC tissues and was associated with a later clinical stage and tumor metastasis. Restoring the expression of miR-644a could significantly suppress the migration and invasion of HGC-27 and SGC-7901 cells, which might be More >

  • Open Access

    ARTICLE

    Paclitaxel Combined with Ticagrelor Inhibits B16F10 and Lewis Lung Carcinoma Cell Metastasis

    Xingjun Meng1,#, Zhihui Cao2,#, Renfeng Liu3,#, Kai Zheng4, Shuai Ding5, Yuefan Gu4, Yonghua Chen6, Jun Lv7, Ping Li8, Li Zhou9, Wenbo Wang10, Shiliang Ji11, Hui He12,*, Hui Yang9,*

    Oncologie, Vol.24, No.2, pp. 283-294, 2022, DOI:10.32604/oncologie.2022.021259

    Abstract It is widely accepted that tumor metastasis is the dominant factor leading to cancer-related death. Tumor metastasis is mediated by cell invasion, blood circulation and lymphatic circulation. Paclitaxel, as a common anti-tumor drug and a mitotic inhibitor, promotes microtubule assembly and inhibits microtubule depolymerization. In addition, ticagrelor, an anti-platelet drug, is used to treat acute coronary syndrome. Increasing numbers of studies have reported that platelets can facilitate tumor metastasis. Therefore, inhibiting the effects of platelets can serve as a novel therapeutic strategy for cancer. To explore the effect of anti-tumor and anti-platelet drugs on tumor More >

  • Open Access

    ARTICLE

    Long Noncoding RNA XIST Regulates miR-137–EZH2 Axis to Promote Tumor Metastasis in Colorectal Cancer

    Xingxiang Liu*†, Lin Cui, Dong Hua*‡

    Oncology Research, Vol.27, No.1, pp. 99-106, 2019, DOI:10.3727/096504018X15195193936573

    Abstract We aimed to investigate the significant role of long noncoding RNA X inactive specific transcript (XIST) in regulating tumor metastasis in colorectal cancer (CRC), as well as its possible mechanism. Expression of lncRNA XIST in CRC tissues and CRC cells was detected. CRC cells were transfected with pc-XIST, blank control si-XIST, or si-control, and then the effects of lncRNA XIST on CRC cell migration and invasion were investigated, along with the interaction between lncRNA XIST and miR-137. lncRNA XIST was upregulated in CRC tissues. Compared with HT29 cells that had low metastatic potential, XIST was… More >

  • Open Access

    ARTICLE

    Heme Oxygenase-1 Inhibits Tumor Metastasis Mediated by Notch1 Pathway in Murine Mammary Carcinoma

    Qiang Li*†1, Qi Liu*1, Wanpeng Cheng*, Huiyan Wei*, Wenqian Jiang*, Fang E*, Yuan Yu*, Jianfeng Jin*, Chaoxia Zou*‡

    Oncology Research, Vol.27, No.6, pp. 643-651, 2019, DOI:10.3727/096504018X15415906335771

    Abstract Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Our results revealed that overexpression of HO-1 strongly inhibits the lung metastasis of 4T1 cells. In in vitro analysis, associated indices for epithelial–mesenchymal transition (EMT), migration, and proliferation of 4T1 cells were evaluated. The results show that HO-1 inhibits EMT, migration, and proliferation of 4T1 cells. In addition, More >

  • Open Access

    ARTICLE

    A Multisclae Probabilisitc Framework to Model Early Steps in Tumor Metastasis

    Muhammad H. Zaman*

    Molecular & Cellular Biomechanics, Vol.4, No.3, pp. 133-142, 2007, DOI:10.3970/mcb.2007.004.133

    Abstract Tumor metastasis is the leading cause of nearly all cancer related deaths. While several experimental and computational studies have addressed individual stages of the complex metastasis process, a comprehensive systems-biology model that links various stages of metastasis has not been put forth as of yet. In this paper we discuss the formulation and application of such a model that utilizes basic principles of cell biology, physics and mechanics to study the migratory patterns of tumor cells as they move from the parent tumor site to the connective tissue via the basement membrane. The model is More >

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