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  • Open Access

    REVIEW

    Clinical implications of single cell sequencing for bladder cancer

    REZA YADOLLAHVANDMIANDOAB1,#, MEHRSA JALALIZADEH1,#, FRANCIELE APARECIDA VECHIA DIONATO1, KEINI BUOSI1, PATRÍCIA A. F. LEME1, LUCIANA S. B. DAL COL1, CRISTIANE F. GIACOMELLI1, ALEX DIAS ASSIS1, NASIM BASHIRICHELKASARI1, LEONARDO OLIVEIRA REIS1,2,*

    Oncology Research, Vol.32, No.4, pp. 597-605, 2024, DOI:10.32604/or.2024.045442 - 20 March 2024

    Abstract Bladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million reported new cases and about 0.2 million deaths per year. In this scoping review, we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines. We searched PubMed, CENTRAL, Embase, and supplemented with manual searches through the Scopus, and Web of Science for published studies until February 2023. We included original studies that used at least one single-cell technology to study bladder cancer. Forty-one publications were included in the review. Twenty-nine studies showed… More > Graphic Abstract

    Clinical implications of single cell sequencing for bladder cancer

  • Open Access

    EDITORIAL

    Editorial: Transcriptome analysis in tumor microenvironment and tumor heterogeneity

    JINHUI LIU1,*, JIAHENG XIE2,*, PEIXIN DONG3

    Oncology Research, Vol.32, No.1, pp. 99-100, 2024, DOI:10.32604/or.2023.045719 - 15 November 2023

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Heterogeneity beyond tumor heterogeneity—SULF2 involvement in Wnt/β-catenin signaling activation in a heterogeneous side population of liver cancer cells

    DONGYE YANG1,#,*, DONGDONG GUO2,3,#, YUNMEI PENG2, DONGMENG LIU1, YANQIU FU1, FEN SUN2, LISHI ZHOU1, JIAQI GUO1, LAIQING HUANG2,3,*

    BIOCELL, Vol.47, No.9, pp. 2037-2049, 2023, DOI:10.32604/biocell.2023.028863 - 28 September 2023

    Abstract Introduction: Sulfatase 2 (SULF2), an endogenous extracellular sulfatase, can remove 6-O-sulfate groups of glucosamine residues from heparan sulfate (HS) chains to modulate the Wnt/β-catenin signaling pathway, which plays an important role in both liver carcinogenesis and embryogenesis. Side population (SP) cells are widely identified as stem-like cancer cells and are closely related to carcinoma metastasis, recurrence, and poor patient prognosis. However, the roles of SULF2 in SP cells of hepatomas are unclear, and the underlying mechanism is undefined. Objectives: This study aimed to compare the heterogeneity between SP cells and non-side population (NSP) cells derived from… More > Graphic Abstract

    Heterogeneity beyond tumor heterogeneity—SULF2 involvement in Wnt/β-catenin signaling activation in a heterogeneous side population of liver cancer cells

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