Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1385-1385, 2024, DOI:10.32604/or.2024.055037

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1379-1379, 2024, DOI:10.32604/or.2024.055034

Abstract This article has no abstract. More >

RUIFANG LI¹, XINRONG NAN^2,*, MING LI^3,*, OMAR RAHHAL³

Oncology Research, Vol.32, No.8, pp. 1323-1334, 2024, DOI:10.32604/or.2024.046965

Abstract Background: Fibroblast activation protein (FAP), a cell surface serine protease, plays roles in tumor invasion and immune regulation. However, there is currently no pan-cancer analysis of FAP. Objective: We aimed to assess the pan-cancer expression profile of FAP, its molecular function, and its potential role in head and neck squamous cell carcinoma (HNSC). Methods: We analyzed gene expression, survival status, immune infiltration, and molecular functional pathways of FAP in The Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) tumors. Furthermore, to elucidate the role of FAP in HNSC, we performed proliferation, migration, and invasion assays… More >

MING ZHUANG, XUE ZHANG, LU LI, LIMING WEN, JIAMIN QIN^*

Oncology Research, Vol.32, No.8, pp. 1347-1357, 2024, DOI:10.32604/or.2024.046170

Abstract Hepatocellular carcinoma (HCC) poses a significant threat to human health. Resistance to sorafenib in the chemotherapy of HCC is a common and significant issue that profoundly impacts clinical treatment. While several members of the transmembrane (TMEM) protein family have been implicated in the occurrence and progression of HCC, the association between TMEM39b and HCC remains unexplored. This study revealed a significant overexpression of TMEM39b in HCC, which correlated with a poor prognosis. Subsequent investigation revealed that RAS-selective lethal 3 (RSL3) induced pronounced ferroptosis in HCC, and knocking down the expression of TMEM39b significantly decreased its More >

WEI JIANG¹, MEI ZHOU^2,*

Oncology Research, Vol.32, No.8, pp. 1359-1368, 2024, DOI:10.32604/or.2024.043423

Abstract Multiple myeloma (MM) is a plasma cell malignancy and remains incurable as it lacks effective curative approaches; thus, novel therapeutic strategies are desperately needed. The study aimed to explore the therapeutic role of dihydromyricetin (DHM) in MM and explore its mechanisms. Human MM and normal plasma samples, human MM cell lines, and normal plasma cells were used for in vitro experiments. Cell counting kit-8 (CCK-8), flow cytometry, and trans-well assays were performed for the assessment of cell viability, apoptosis, migration, and invasion, respectively. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to assess the mRNA expression… More > Graphic Abstract

Md. Atiqur Rahman¹, Mustavi Ibne Masum¹, Khan Md Hasib², M. F. Mridha^3,*, Sultan Alfarhood⁴, Mejdl Safran^4,*, Dunren Che⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2425-2448, 2024, DOI:10.32604/cmes.2024.050760

Abstract Brain tumors pose a significant threat to human lives and have gained increasing attention as the tenth leading cause of global mortality. This study addresses the pressing issue of brain tumor classification using Magnetic resonance imaging (MRI). It focuses on distinguishing between Low-Grade Gliomas (LGG) and High-Grade Gliomas (HGG). LGGs are benign and typically manageable with surgical resection, while HGGs are malignant and more aggressive. The research introduces an innovative custom convolutional neural network (CNN) model, Glioma-CNN. GliomaCNN stands out as a lightweight CNN model compared to its predecessors. The research utilized the BraTS 2020 More >

LISANNE K.A. NEIJENHUIS^1,2,3,#, LEUTA L. NAUMANN^4,#, SONIA A.M. FERKEL¹, SAMUEL J.S. RUBIN¹, STEPHAN ROGALLA^1,*

Oncology Research, Vol.32, No.7, pp. 1163-1172, 2024, DOI:10.32604/or.2024.050907

Abstract Background: Osteosarcoma is the most common malignant primary bone tumor. The prognosis for patients with disseminated disease remains very poor despite recent advancements in chemotherapy. Moreover, current treatment regimens bear a significant risk of serious side effects. Thus, there is an unmet clinical need for effective therapies with improved safety profiles. Taurolidine is an antibacterial agent that has been shown to induce cell death in different types of cancer cell lines. Methods: In this study, we examined both the antineoplastic and antiangiogenic effects of taurolidine in animal models of osteosarcoma. K7M2 murine osteosarcoma cells were… More >

PAULINA CHMIEL^1,2, ALEKSANDRA SłOWIKOWSKA^1,2, ŁUKASZ BANASZEK^1,2, ANNA SZUMERA-CIEćKIEWICZ³, BARTłOMIEJ SZOSTAKOWSKI¹, MATEUSZ J. SPAłEK^1,4,*, TOMASZ ŚWITAJ¹, PIOTR RUTKOWSKI¹, ANNA M. CZARNECKA¹

Oncology Research, Vol.32, No.7, pp. 1141-1162, 2024, DOI:10.32604/or.2024.050350

Abstract Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic rate. Diagnostic challenges arise from the diverse pathological presentation, variable symptomatology, and lack of different imaging features. However, IMT is identified by the fusion of the anaplastic lymphoma kinase (ALK) gene, which is present in approximately 70% of cases, with various fusion partners, including ran-binding protein 2 (RANBP2), which allows confirmation of the diagnosis. While surgery is the preferred approach for localized tumors, the optimal long-term treatment for advanced or metastatic disease is difficult… More >

YUANLIN LIU^1,3,#, YAN LIU^2,#, YAN WANG², QIANG WANG², YAN YAN¹, DANDAN ZHANG^2,*, HUIQIN LIU^2,*

Oncology Research, Vol.32, No.7, pp. 1221-1229, 2024, DOI:10.32604/or.2024.047454

Abstract At present, the role of many long non-coding RNAs (lncRNAs) as tumor suppressors in the formation and development of cervical cancer (CC) has been studied. However, lncRNA prostate cancer gene expression marker 1 (PCGEM1), whose high expression not only aggravates ovarian cancer but also can induce tumorigenesis and endometrial cancer progression, has not been studied in CC. The objective of this study was to investigate the expression and the underlying role of PCGEM1 in CC. The relative expression of PCGEM1 in CC cells was detected by real-time PCR. After the suppression of PCGEM1 expression by… More > Graphic Abstract

Yuting Zhou¹, Xuemei Yang¹, Junping Yin^2,3,4,*, Shiqi Liu¹

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 5313-5333, 2024, DOI:10.32604/cmc.2024.052060

Abstract Gliomas have the highest mortality rate of all brain tumors. Correctly classifying the glioma risk period can help doctors make reasonable treatment plans and improve patients’ survival rates. This paper proposes a hierarchical multi-scale attention feature fusion medical image classification network (HMAC-Net), which effectively combines global features and local features. The network framework consists of three parallel layers: The global feature extraction layer, the local feature extraction layer, and the multi-scale feature fusion layer. A linear sparse attention mechanism is designed in the global feature extraction layer to reduce information redundancy. In the local feature… More >