Yifan Lian*1, Weiming Fan†1, Yanlin Huang‡, Hongbo Wang*, Jialiang Wang*, Liang Zhou‡, Xiaojuan Wu‡, Meihai Deng†, Yuehua Huang*‡
Oncology Research, Vol.26, No.5, pp. 691-701, 2018, DOI:10.3727/096504017X15101398724809
Abstract Trophinin-associated protein (TROAP) was a protein first identified to mediate the process of embryo transplantation and later found to be involved in microtubule regulation. However, little is known about the role
of TROAP in hepatocellular carcinoma (HCC). In the present study, we reported that both TROAP mRNA
and protein expressions were downregulated in human HCC samples as well as cell lines. A high level of
TROAP was associated with small tumor size (p<0.05), minor tumor nodules (p<0.01), and mild vein invasion (p<0.05). We further constructed in vitro TROAP depletion and overexpression HCC cell models. TROAP
depletion significantly More >
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