Zewei Zhang*1, Chao Xu†1, Xiafang Zhang†1, Lulu Huang†, Cheng Zheng‡, Haitao Chen†, Yan Wang†, Haixing Ju§, Qinghua Yao†
Oncology Research, Vol.25, No.5, pp. 691-699, 2017, DOI:10.3727/096504016X14774897404770
Abstract The tripartite motif-containing protein 11 (TRIM11), a member of the TRIM protein family, has attracted
much attention because of its involvement in the development of the central nervous system. It has gained
renewed focus because of its newly found function in promoting tumors. However, little is known about its
role in hepatocellular carcinoma (HCC). In the present study, we found TRIM11 to be overexpressed in HCC
tissues and cell lines. Downregulation of TRIM11 inhibited HCC cell proliferation and invasion in vitro
and in vivo as well as suppressed the epithelial–mesenchymal transition (EMT) process. In addition, More >
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