Hongwei Tan, Jin Qi, Guanghua Chu, Zhaoyang Liu
Oncology Research, Vol.25, No.4, pp. 551-558, 2017, DOI:10.3727/096504016X14758370595285
Abstract Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite motif (TRIM)
protein family, has been shown to play a role in tumor development and progression. However, the role of
TRIM16 in ovarian cancer has never been revealed. Thus, in this study, we investigated the roles and mechanisms of TRIM16 in ovarian cancer. Our results demonstrated that TRIM16 expression was low in ovarian
cancer cell lines. In addition, overexpression of TRIM16 significantly inhibited the migration and invasion in
vitro, as well as suppressed the epithelial–mesenchymal transition (EMT) phenotype in ovarian cancer cells.
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