Yan Li1, Wei Guo1, Shen Liu, Bin Zhang, Bing-Bing Yu, Bo Yang, Shun-Li Kan, Shi-Qing Feng
Oncology Research, Vol.25, No.6, pp. 1021-1026, 2017, DOI:10.3727/096504016X14821477992177
Abstract Transmembrane protein 45B (TMEM45B) is a member of the TMEM family of proteins and has been reported
to be expressed abnormally in different kinds of human tumors. However, the biological function of TMEM45B
in osteosarcoma remains unclear. The objective of this study was to investigate the role of TMEM45B in
regulating the biological behavior of osteosarcoma cells. Our results demonstrated that the expression of
TMEM45B at both the protein and mRNA levels was dramatically upregulated in human osteosarcoma cell
lines. Knockdown of TMEM45B significantly suppressed the proliferation, migration, and invasion of U2OS
cells in vitro. More >
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