REZA YADOLLAHVANDMIANDOAB^1,#, MEHRSA JALALIZADEH^1,#, FRANCIELE APARECIDA VECHIA DIONATO¹, KEINI BUOSI¹, PATRÍCIA A. F. LEME¹, LUCIANA S. B. DAL COL¹, CRISTIANE F. GIACOMELLI¹, ALEX DIAS ASSIS¹, NASIM BASHIRICHELKASARI¹, LEONARDO OLIVEIRA REIS^1,2,*

Oncology Research, Vol.32, No.4, pp. 597-605, 2024, DOI:10.32604/or.2024.045442 - 20 March 2024

Abstract Bladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million reported new cases and about 0.2 million deaths per year. In this scoping review, we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines. We searched PubMed, CENTRAL, Embase, and supplemented with manual searches through the Scopus, and Web of Science for published studies until February 2023. We included original studies that used at least one single-cell technology to study bladder cancer. Forty-one publications were included in the review. Twenty-nine studies showed… More > Graphic Abstract

Jamil S. Syed¹, Kevin A. Nguyen¹, Alfie Suarez-Sariemento¹, Cynthia Leung¹, Marianne Casilla-Lennon¹, Jay D. Raman², Brian Shuch^1,3

Canadian Journal of Urology, Vol.26, No.2, pp. 9699-9707, 2019

Abstract Introduction: Approximately 7% of patients with localized upper tract urothelial cancer (UTUC) are treated without definitive therapy. Understanding outcomes and alternative therapy would aid in counseling older patients with comorbidities.
Materials and methods: We utilized the National Cancer Database to identify patients with localized UTUC managed non-surgically between 2004 and 2013. Patient demographics, comorbidity, tumor grade, and chemotherapy and radiation utilization were recorded. Survival analyses were performed with the Kaplan-Meier method and a Cox proportional hazard regression model.
Results: We identified 3157 (10.9%) patients with localized UTUC who did not receive definitive surgery. Median age was 79 years,… More >

Facundo Davaro¹, Allison May¹, Coleman McFerrin², Syed J. Raza¹, Sameer Siddiqui¹, Zachary Hamilton¹

Canadian Journal of Urology, Vol.26, No.5, pp. 9938-9944, 2019

Abstract Introduction: To evaluate the overall survival and pathologic downstaging effect of neoadjuvant chemotherapy for upper tract urothelial cell carcinoma.
Materials and methods: The National Cancer Database (NCDB) was queried for patients with stage II-IV upper tract urothelial cell carcinoma undergoing definitive surgical resection (nephroureterectomy) from 2004-2015. Patients with metastatic disease were excluded. Cohorts were stratified by receipt of neoadjuvant chemotherapy (NAC). Kaplan-Meier analysis and Cox regression were used to evaluate overall survival. Logistic regression was used to predict the odds of pathologic downstaging to non-invasive disease (< pT2). Propensity score matched analysis was performed between groups.
Results: A… More >

Jason Warncke, Sharon White, Mary O’Keefe, Fernando Kim, Rodrigo Donalisio da Silva

Canadian Journal of Urology, Vol.25, No.4, pp. 9421-9423, 2018

Abstract Transitional cell carcinoma is the most common type of bladder cancer in the United States. This case report discusses the finding of primary bladder carcinoid tumor (also called well-differentiated neuroendocrine tumor) in a woman with gross hematuria. With only 15-20 reported cases, primary bladder carcinoid is rare and the approach to treatment is unclear. There have been two muscle-invasive cases reported which required more extensive treatment plans. The patient presented in this case underwent complete transurethral resection of the tumor with the recommendation of surveillance cystoscopy every 3 months. More >

Yu-Kuan Lin, Amanda Deliere, Kathleen Lehman, Lewis E. Harpster, Matthew G. Kaag, Jay D. Raman

Canadian Journal of Urology, Vol.21, No.4, pp. 7369-7373, 2014

Abstract Introduction: Patients with upper tract urothelial carcinoma (UTUC) are often elderly and comorbid owing to associated risk factors for developing this malignancy. Perioperative complications may be significant in such a surgical population. We define the incidence and risk factors associated with perioperative complications occurring within 30 days of radical nephroureterectomy (RNU).
Materials and methods: Medical records of 92 consecutive patients undergoing RNU were reviewed. Complications occurring within 30 days of surgery were graded using the modified Clavien-Dindo classification. The number, severity, and type of complications were recorded. Minor complications were classified as Clavien II or less, while… More >

Adam D. Berneking, Henry M. Rosevear, Eric J. Askeland, Mark R. Newton, Michael A. O’Donnell, James A. Brown

Canadian Journal of Urology, Vol.20, No.4, pp. 6826-6831, 2013

Abstract Introduction: Recent evidence suggests that radical cystectomy may be underutilized in elderly patients, despite literature supporting acceptable morbidity/mortality in this population. However, there is a paucity of literature reporting complications in a standardized manner. Therefore, we evaluated the morbidity and mortality of octogenarians treated with radical cystectomy using the modified Clavien complication reporting system.
Materials and methods: We retrospectively reviewed 443 consecutive patients undergoing radical cystectomy at our institution between January 2000 and April 2010. Patients who underwent cystectomy for benign conditions were excluded, leaving 359 for analysis. Baseline demographic and perioperative data were reviewed and all… More >

Zurab Davili¹, Zahi Makhuli¹, Christopher Hartman¹, Rong Rong²

Canadian Journal of Urology, Vol.18, No.1, pp. 5560-5563, 2011

Abstract We report a case of a 46-year-old male who presented to the outpatient urology clinic with an incidental bladder mass. Office cystoscopy revealed two synchronous tumors of different morphology. Endoscopic resection was performed to remove the smaller, papillary tumor, of which pathology revealed Ta, Grade 1 urothelial carcinoma. A second open resection was performed to remove the second tumor, a benign leiomyoma. More >

Bob Djavan

Canadian Journal of Urology, Vol.18, No.1, pp. 5536-5536, 2011

Abstract This article has no abstract. More >

Jacobo Arce, Josep M. Gaya, Jorge Huguet, Oscar Rodriguez, Joan Palou, Humberto Villavicencio

Canadian Journal of Urology, Vol.18, No.1, pp. 5529-5536, 2011

Abstract Objectives: To determine which patients may benefit from prostate-sparing surgery and which factors are predictive of invasive prostatic involvement.
Materials and methods: A total of 717 men underwent radical cystoprostatectomy (RC) for bladder transitional cell carcinoma (TCC) between 1978 and 2002. Analysis of prostatic urethral involvement by transitional cell carcinoma (pTCC) and of invasive prostatic involvement by TCC was performed according to recurrence, presence of carcinoma in situ (CIS) and multifocality, previous intravesical chemotherapy, grade, stage and location of bladder tumor, presence of CIS in precystectomy transurethral resection (TUR) and indication for RC.
Results: pTCC was present in… More >

Andrew C. Strine¹, David J. Grignon², Chandru P. Sundaram³

Canadian Journal of Urology, Vol.18, No.4, pp. 5856-5859, 2011

Abstract Ablative therapy has recently emerged as an option for the treatment of small renal masses (SRMs). Benign tumors and indolent renal cell carcinoma (RCC) represent a majority of these masses, although an additional but often unappreciated consideration is upper tract urothelial carcinoma (UC). We report the case of a 74-year-old man with upper tract UC presenting as a SRM without any apparent involvement of the pelvicalyceal system, leading to its inadvertent cryoablation. We also discuss the role of renal biopsy in the management of SRMs undergoing an ablative procedure. More >