Hung-Tsung Lee*, Cheng-Hsieh Huang†, Wuan-Chun Chen†, Chi-Shan Tsai†, Yu-Lin Chao†, Szu-Han Liu†, Jun-Hong Chen†, Yi-Ying Wu‡, Yi-Ju Lee†§
Oncology Research, Vol.26, No.8, pp. 1175-1182, 2018, DOI:10.3727/096504018X15149761920868
Abstract Lung cancer is the leading cause of cancer deaths worldwide. Given that the major threat of cancer is
metastasis, delineation of the molecular mechanism underlying it would help devise therapeutic strategies.
Transglutaminase 2 (TG2), belonging to the transglutaminase superfamily, is a versatile protein with enzymatic and nonenzymatic functions. It mainly localizes inside the cell, but also appears extracellularly. Recent
findings have demonstrated the involvement of TG2 in cancer development. Here we examine the role of
TG2 in metastasis of lung cancer using a lung cancer cell line CL1-0, which exhibits low invasiveness, and its
invasive… More >
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