Cheng Xu*1, Lu Cao*1, Jianhua Liu†1, Zhongrun Qian‡, Yu Peng§, Wenjing Zhu§, Yongming Qiu‡, Yingying Lin‡¶
Oncology Research, Vol.25, No.3, pp. 407-415, 2017, DOI:10.3727/096504016X14743350548249
Abstract Elevated circulating asparaginyl endopeptidase (AEP), a novel lysosomal protease, has been found in breast
cancer, and AEP is thus considered to be a prognostic factor in this disease. However, the pathological functions of circulating AEP in the development of breast cancer and the potential of AEP-targeted therapy remain
unclear. We used MMTV-PyVmT transgenic mice, which spontaneously develop mammary tumors. Western
blotting showed overexpression of AEP in both primary tumor tissue and lung metastases compared to their
normal counterparts. Moreover, the concentration of circulating AEP gradually increased in the serum during
the development of mammary tumors. More >
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