Guo-ying Zhang1, Ai-hua Liu1, Guo-min Li, Jian-rong Wang
Oncology Research, Vol.24, No.1, pp. 33-39, 2016, DOI:10.3727/096504016X14575597858654
Abstract Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) is a nucleocytoplasmic shuttling protein, and its expression is associated with cancer aggressiveness. However, the role of
HPIP in ovarian cancer is still unclear. Here, we aimed to clarify the role of HPIP in epithelial–mesenchymal
transition (EMT) process of ovarian cancer cells, stimulated by transforming growth factor (TGF)-β1. In this
study, we found that HPIP was highly expressed in ovarian cancer cells, and TGF-β1 treatment induced HPIP
expression in ovarian cancer cells. In addition, knockdown of HPIP suppressed TGF-β1-induced EMT and
migration/invasion in ovarian cancer cells. Moreover, More >
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