Feng Guo, Yaquan Liu
Oncology Research, Vol.26, No.2, pp. 183-189, 2018, DOI:10.3727/096504017X14837020772250
Abstract Transforming acidic coiled-coil protein 3 (TACC3) is a member of the TACC family and plays an important
role in regulating cell mitosis, transcription, and tumorigenesis. However, the expression pattern and roles of
TACC3 in renal cell carcinoma (RCC) remain unclear. The aim of this study was to investigate the role of
TACC3 in RCC. We demonstrated overexpression of TACC3 in human RCC cell lines at both RNA and protein
levels. Moreover, knockdown of TACC3 repressed RCC cell proliferation, migration, and invasion in vitro.
In addition, knockdown of TACC3 inactivated PI3K/Akt signaling in RCC cells. Furthermore, More >
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