Jun Yuan¹, Rongpeng Liu⁴, Xiaoyun Wang^3,*, Haihui Fu^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2267-2284, 2024, DOI:10.32604/phyton.2024.055338 - 30 September 2024

Abstract Cadmium (Cd) has seriously affected the quality of traditional Chinese medicinal material Salvia miltiorrhiza in recent years, threatening human health. The physiological and metabolic profiles of S. miltiorrhiza in response to Cd stress have been revealed in previous studies. However, transcriptional and post-transcriptional regulation in response to different degrees of Cd (0, 25, 50, and 100 mg/kg) stress in S. miltiorrhiza remains unclear. Here, transcriptome atlas in S. miltiorrhiza under different degrees of Cd Stress was unveiled using RNA sequencing (RNA-seq). These results showed that the profiles of gene expression were different in the response to Cd treatment. Defense More >

Dandan Yuan, Ju Cai, Tao Zhang, Sisi Wang, Xiuliu Yang, Yan Li^*

Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 1875-1896, 2024, DOI:10.32604/phyton.2024.052190 - 30 August 2024

Abstract The WRKY transcription factor gene family is one of the unique gene families in plants. It plays an important role in response to abiotic stresses such as cold and drought, hormone signal transduction, regulation of biosynthesis, leaf senescence seed germination, etc. However, little information is available about WRKY transcription factors in Verbena bonariensis. In this study, 70 VbWRKY genes were identified from the whole genome. The phylogenetic analysis of the WRKY gene family in V. bonariensis and Arabidopsis shows that the WRKY genes in V. bonariensis can be divided into three groups: I, II, and III, which contain 13, 47, and… More >

Mingchuan Yang¹, Jia Zheng², Wenhui Yu¹, Yanghua Li², Yali Wang¹, Zilu Zhang¹, Zhenhui Kang^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.7, pp. 1503-1521, 2024, DOI:10.32604/phyton.2024.051718 - 30 July 2024

Abstract Sorghum is not only an important bio-energy crop but also a vital raw material for brewing. Exogenous copper affects the growth and metabolism of crops in specific ways. This study identified 8475 differentially expressed genes (DEGs) by high-throughput transcriptome sequencing in the sorghum cultivar ‘Jinnuoliang 2’ after 24 h of treatment with 10 mM CuSO. Using GO analysis, 476 genes were functionally annotated, which were mainly related to catabolism and biosynthetic processes. Additionally, 90 pathways were annotated by employing the KEGG analysis. Among them, glutathione metabolism and peroxisome were induced, while photosynthesis, photosynthesis-antenna protein, and… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1373-1373, 2024, DOI:10.32604/or.2024.055031 - 17 July 2024

Abstract This article has no abstract. More >

HUI SUN, MASANORI KAWANO^*, TATSUYA IWASAKI, ICHIRO ITONAGA, YUTA KUBOTA, HIROSHI TSUMURA, KAZUHIRO TANAKA

Oncology Research, Vol.32, No.8, pp. 1369-1370, 2024, DOI:10.32604/or.2024.052652 - 17 July 2024

Abstract This article has no abstract. More >

Yuan Tian, Lulu Zhi, Ping Li^*, Xiangyang Hu^*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1101-1116, 2024, DOI:10.32604/phyton.2024.050220 - 27 June 2024

Abstract Seed viability is an essential feature for genetic resource conservation as well as sustainable crop production. Long-term storage induces seed viability deterioration or seed aging, accompanied by the accumulation of toxic reactive oxygen species (ROS) to suppress seed germination. Controlled deterioration treatment (CDT) is a general approach for mimicking seed aging. The transcription factor ANAC089 was previously reported to modulate seed primary germination. In this study, we evaluated the ability of ANAC089 to control seed viability during aging. Compared with that in the wild-type line, the mutation of ANAC089 significantly increased HO, thereby reducing seed viability after… More >

Xiaozhuo Xu^1,2, Yilin Huang^1,2, Xu Han^2,*

Congenital Heart Disease, Vol.19, No.2, pp. 233-246, 2024, DOI:10.32604/chd.2024.050231 - 16 May 2024

Abstract Background: Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart diseases in clinical treatment. In cardiac tissues, resident macrophages fulfill critical functions in maintaining a stable cardiac state and have strong regenerative capacity and organ specificity. However, the molecular mechanisms of macrophages in HLHS remained unclear. Methods: Single-nucleus RNA sequencing (snRNA-seq) data of HLHS and healthy control (donors) samples obtained from the Gene Expression Omnibus (GEO) database were normalized and clustered using the Seurat package. The “FindMarkers” function was used to screen differentially expressed genes (DEGs) between the HLHS and donor… More > Graphic Abstract

QINGJIAN HE¹, HUIXIN ZHU^2,3, SHANHONG FANG^4,5,*

BIOCELL, Vol.48, No.2, pp. 205-216, 2024, DOI:10.32604/biocell.2023.045109 - 23 February 2024

Abstract Introduction: Dexamethasone (Dex) caused impaired osteoblast differentiation and oxidative stress (OS) in bone marrow mesenchymal stem cells (BMSCs). This work sought to elucidate the precise molecular pathway through which Dex influences osteogenic differentiation (OD) and OS in BMSCs. Methods: The expression of Runt-related transcription factor 1 (RUNX1) and alpha-2 macroglobulin (A2M) was assessed in Dex-treated BMSCs using qRT-PCR and Western Blot. Following the functional rescue experiments, cell proliferation was determined by MTT assay, reactive oxygen species (ROS) expression by DCFH-DA fluorescent probe, lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) expression… More >

HUI SUN, MASANORI KAWANO^*, TATSUYA IWASAKI, ICHIRO ITONAGA, YUTA KUBOTA, HIROSHI TSUMURA, KAZUHIRO TANAKA

Oncology Research, Vol.32, No.3, pp. 463-476, 2024, DOI:10.32604/or.2023.044085 - 06 February 2024

Abstract An important factor in the emergence and progression of osteosarcoma (OS) is the dysregulated expression of microRNAs (miRNAs). Transcription factor 7-like 1 (TCF7L1), a member of the T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factor family, interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding protein. This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while… More > Graphic Abstract

Jing Liu^1,*, Defeng Shu¹, Zilong Tan¹, Mei Ma¹, Huanhuan Yang¹, Ning Guo^1,2, Shipeng Li¹, Dayong Cui^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 63-79, 2024, DOI:10.32604/phyton.2023.045940 - 26 January 2024

Abstract INDETERMINATE-DOMAIN proteins (IDDs) are a plant-specific transcription factor family characterized by a conserved ID domain with four zinc finger motifs. Previous studies have demonstrated that IDDs coordinate a diversity of physiological processes and functions in plant growth and development, including floral transition, plant architecture, seed and root development, and hormone signaling. In this review, we especially summarized the latest knowledge on the functions and working models of IDD members in Arabidopsis, rice, and maize, particularly focusing on their role in the regulatory network of biotic and abiotic environmental responses, such as gravity, temperature, water, and More >