Fuan Xiao¹, Tong Lai¹, Yutong Guan¹, Jiaming Hong¹, Honglai Zhang¹, Guoyu Yang², Zhengfei Wang^1,*

CMC-Computers, Materials & Continua, Vol.76, No.1, pp. 35-48, 2023, DOI:10.32604/cmc.2023.038937 - 08 June 2023

Abstract Traditional Chinese Medicine (TCM) is one of the most promising programs for disease prevention and treatment. Meanwhile, the quality of TCM has garnered much attention. To ensure the quality of TCM, many works are based on the blockchain scheme to design the traceability scheme of TCM to trace its origin. Although these schemes can ensure the integrity, sharability, credibility, and immutability of TCM more effectively, many problems are exposed with the rapid growth of TCM data in blockchains, such as expensive overhead, performance bottlenecks, and the traditional blockchain architecture is unsuitable for TCM data with… More >

Hai Long¹, Zhe Wang¹, Yidi Cui^2,3, Junhui Wang⁴, Bo Gao⁵, Chao Chen⁵, Yan Zhu^5,*, Heinrich Herre¹

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 5197-5217, 2022, DOI:10.32604/cmc.2022.029365 - 28 July 2022

Abstract Psoriasis is a chronic, non-communicable, painful, disfiguring and disabling disease for which there is no cure, with great negative impact on patients’ quality of life (QoL). Diagnosis and treatment with traditional Chinese medical technique based on syndrome differentiation has been used in practice for a long time and proven effective, though, up to now, there are only a few available studies about the use of semantic technologies and the knowledge systems that use Traditional Chinese Medicine (TCM)-syndrome differentiation for information retrieval and automated reasoning. In this paper we use semantic techniques based on ontologies to… More >

Yang Chen^1,#, Huan Wu^2,#, Annan Jiao³, Jiabing Tong⁴, Jie Zhu⁵, Mei Zhang¹, Zegeng Li^4,*, Ping Li^1,*

Oncologie, Vol.24, No.2, pp. 295-307, 2022, DOI:10.32604/oncologie.2022.022116 - 29 June 2022

Abstract Objectives: Lung cancer is a common and malignant tumor in adults and ranks first in the incidence and mortality of the top five malignant tumors in China. Our previous studies have shown that QYSL prescription can balance lung cancer mice Th1/Th2 and inhibit tumor cell immune escape. Here, we examined the effects of QYSL on lung cancer associated macrophage and the potential associated mechanism. Methods: C57BL/6 mice were injected with Lewis lung cancer cells and treated with QYSL. FACS, RT-PCR, and western blot were used to examined the effect of QYSL on tumor immune microenvironment. Results: We… More >

Lingdi Liu, Chunxiu Wen, Wei Tian, Xiaoliang Xie, Saiqun Wen, Tao Jiang^*

Phyton-International Journal of Experimental Botany, Vol.91, No.10, pp. 2313-2330, 2022, DOI:10.32604/phyton.2022.020295 - 30 May 2022

Abstract Forsythiae Fructus, the fruit of Forsythia suspense is a traditional Chinese hebal medicine that has the antiviral and antioxidant effects in China. Modern analytical chemistry studies showed that the extracts of Forsythiae Fructus contain many bioactive components, such as flavonoids, lignans, phenolic acids, and terpenoids, which can be used to anti-inflammatory and treat toxicity, tonsillitis, ulcers, pharyngitis and acute nephritis. In order to study the types and quantities of metabolites in Forsythiae Fructus, we isolated, identified and analysed metabolites between two varieties of Forsythiae Fructus using UPLC/ESI-Q TRAP-MS/MS. The results showed that a total of 407… More >

Dezheng Zhang^1,2, Qi Jia^1,2, Shibing Yang^1,2, Xinliang Han², Cong Xu³, Xin Liu^1,4, Yonghong Xie^1,2,*

CMC-Computers, Materials & Continua, Vol.71, No.1, pp. 159-170, 2022, DOI:10.32604/cmc.2022.017295 - 03 November 2021

Abstract Syndrome differentiation is the core diagnosis method of Traditional Chinese Medicine (TCM). We propose a method that simulates syndrome differentiation through deductive reasoning on a knowledge graph to achieve automated diagnosis in TCM. We analyze the reasoning path patterns from symptom to syndromes on the knowledge graph. There are two kinds of path patterns in the knowledge graph: one-hop and two-hop. The one-hop path pattern maps the symptom to syndromes immediately. The two-hop path pattern maps the symptom to syndromes through the nature of disease, etiology, and pathomechanism to support the diagnostic reasoning. Considering the… More >

Jialin Ma^1,*, Zhaojun Wang², Hai Guo³, Qian Xie^1,4, Tao Wang⁴, Bolun Chen⁵

Computer Systems Science and Engineering, Vol.40, No.3, pp. 979-993, 2022, DOI:10.32604/csse.2022.016759 - 24 September 2021

Abstract Syndrome differentiation-based treatment is one of the key characteristics of Traditional Chinese Medicine (TCM). The process of syndrome differentiation is difficult and challenging due to its complexity, diversity and vagueness. Analyzing syndrome principles from historical records of TCM using data mining (DM) technology has been of high interest in recent years. Nevertheless, in most relevant studies, existing DM algorithms have been simply developed for TCM mining, while the combination of TCM theories or its characteristics with DM algorithms has rarely been reported. This paper presents a novel Symptom-Syndrome Topic Model (SSTM), which is a supervised probabilistic More >

XINGYU MEI, ZHOUWEI WU, CHENGZHONG ZHANG, YUE SUN, WEIMIN SHI^*

BIOCELL, Vol.45, No.6, pp. 1551-1559, 2021, DOI:10.32604/biocell.2021.015376 - 01 September 2021

Abstract Vitiligo results in an autoimmune disorder destructing skin pigment cells, melanocytes (Mcs). This study aimed to investigate whether Astragaloside IV (AIV) could efficiently induce differentiation of bone marrow mesenchymal stem cells (BMMSCs) into Mcs. BMMSCs were induced and differentiated into Mcs with 0.1, 0.2, and 0.4 mg/L AIV during 150-day. Morphologic changes of differentiated cells were observed. Levels of some melanocytic specific genes (TRP-1, TRP-2, MART-1, Mitf) were measured with quantitative polymerase chain reaction (qPCR) at 90, 120, and 150 days of induction. After 90-day induction, the differentiated cells with 0.4 mg/L AIV demonstrated the typical morphology… More >

Bin Xiao^*1, Chao Liu^*†1, Bing-tong Liu^*1, Xuan Zhang^*, Rong-rong Liu^*, Xue-Wu Zhang^*

Oncology Research, Vol.23, No.6, pp. 311-320, 2015, DOI:10.3727/096504016X14567549091341

Abstract Previous studies have shown that 5,2',4'-trihydroxy-6,7,5'-trimethoxyflavone (TTF1) is the primary anticancer constituent of the traditional Chinese medicinal plant Sorbaria sorbifolia (SS), which has been applied to treat cancer in China. In this study, we investigated the in vitro and in vivo antitumor effects and biological mechanisms of small-molecule TTF1 nanoparticles (TTF1-NPs). The effects of TTF1-NPs on cell growth and apoptosis were investigated using human hepatoma cells. The molecular changes associated with the effects of TTF1-NPs were analyzed by immunocytochemistry and Western blot analysis. The in vivo effect of TTF1-NPs was investigated using the HepG2 tumor xenograft More >