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  • Open Access

    ARTICLE

    Mechanism of NURP1 in temozolomide resistance in hypoxia-treated glioma cells via the KDM3A/TFEB axis

    TAO LI#, XIN FU#, JIE WANG, WEI SHANG, XIAOTONG WANG, LINYUN ZHANG, JUN LI*

    Oncology Research, Vol.31, No.3, pp. 345-359, 2023, DOI:10.32604/or.2023.028724

    Abstract Temozolomide (TMZ) resistance is a major obstacle in glioma treatment. Nuclear protein-1 (NUPR1) is a regulator of glioma progression. This study investigated the mechanism of NUPR1 in TMZ resistance in hypoxia-treated glioma cells and its mechanism in modulating autophagy. We treated TMZ-resistant cells U251-TMZ and T98G-TMZ to normoxia or hypoxia and silenced NUPR1 in hypoxia-treated U251-TMZ and T98G-TMZ cells to assess cell viability, proliferation, apoptosis, LC3-II/LC3-I and p62 expressions, and autophagic flux under different concentrations of TMZ. We found that hypoxia upregulated NUPR1 expression and autophagy while NUPR1 silencing suppressed hypoxia-induced TMZ resistance and autophagy in glioma cells. We also… More > Graphic Abstract

    Mechanism of NURP1 in temozolomide resistance in hypoxia-treated glioma cells via the KDM3A/TFEB axis

  • Open Access

    ARTICLE

    Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide

    Jia Liu*, Ying Zhang, Shulan Sun, Guirong Zhang, Ke Jiang,§ Peixin Sun*, Ye Zhang*, Bing Yao*, Rui Sui*, Yi Chen*, Xu Guo*, Tao Tang*, Ji Shi*, Haiyang Liang*, Haozhe Piao*

    Oncology Research, Vol.27, No.4, pp. 475-486, 2019, DOI:10.3727/096504018X15270916676926

    Abstract Glioma is the most common malignant tumor of the central nervous system, and it is characterized by high relapse and fatality rates and poor prognosis. Bufalin is one of the main ingredients of Chan-su, a traditional Chinese medicine (TCM) extracted from toad venom. Previous studies revealed that bufalin exerted inhibitory effects on a variety of tumor cells. To demonstrate the inhibitory effect of bufalin on glioma cells and glioma stem-like cells (GSCs) and discuss the underlying mechanism, the proliferation of glioma cells was detected by MTT and colony formation assays following treatment with bufalin. In addition, we investigated whether bufalin… More >

  • Open Access

    ARTICLE

    Evaluation of MGMT Gene Methylation in Neuroendocrine Neoplasms

    Rosa Della Monica*1, Mariella Cuomo*†1, Roberta Visconti, Annabella di Mauro§, Michela Buonaiuto*, Davide Costabile*†, Giulia De Riso, Teodolinda Di Risi*, Elia Guadagno, Roberto Tafuto#, Sabrina Lamia**, Alessandro Ottaiano††, Paolo Cappabianca#, Maria Laura Del Basso de Caro, Fabiana Tatangelo§, Juergen Hench‡‡, Stephan Frank‡‡, Salvatore Tafuto**, Lorenzo Chiariotti*†

    Oncology Research, Vol.28, No.9, pp. 837-845, 2020, DOI:10.3727/096504021X16214197880808

    Abstract Unresectable neuroendocrine neoplasms (NENs) often poorly respond to standard therapeutic approaches. Alkylating agents, in particular temozolomide, commonly used to treat high-grade brain tumors including glioblastomas, have recently been tested in advanced or metastatic NENs, where they showed promising response rates. In glioblastomas, prediction of response to temozolomide is based on the assessment of the methylation status of the MGMT gene, as its product, O6 -methylguanine-DNA methyltransferase, may counteract the damaging effects of the alkylating agent. However, in NENs, such a biomarker has not been validated yet. Thus, we have investigated MGMT methylation in 42 NENs of different grades and from… More >

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