Bui Thi Kim Ly*, Hoang Thanh Chi†‡
Oncology Research, Vol.26, No.8, pp. 1201-1205, 2018, DOI:10.3727/096504018X15154104709325
Abstract FMS-like tyrosine kinase-3 fragments from exon 14 to the end without any mutations or deletions have been
reported to fuse to ETV6 (TEL) in a few cases of myeloid/lymphoid neoplasms with eosinophilia carrying a
translocation t(12;13)(p13;q12). This fusion protein confers constitutive activation on the FLT3 fragment and
induces factor-independent growth in transfected Ba/F3 cells, indicating that it is an oncoprotein. However, the
mechanism controlling the stability of this oncoprotein is unknown. In this study, we focus on finding factors
controlling the stability of ETV6/FLT3. We have shown that the stability of ETV6/FLT3 is regulated by… More >
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