Xianguang Feng*, Wenhuan Yao†, Zengzhen Zhang*, Fangshui Yuan*, Li Liang*, Jingqiang Zhou*, Shuang Liu*, Jiqing Song‡
Oncology Research, Vol.26, No.6, pp. 959-966, 2018, DOI:10.3727/096504017X15145624664031
Abstract Tbx3, a member of the T-box family of transcription factors, contributes directly to tumor formation, migration,
and invasion. However, the role of Tbx3 in the metastasis of HCC remains unclear. In the present study, Tbx3
expression was detected in HCC tissues and cells by Western blot, and Tbx3 expression was regulated by use of
siRNAs or lentivirus-mediated vectors. Here we found that Tbx3 protein expression increased in HCC tissues
and cell lines. Tbx3 expression was positively associated with multiple tumor nodes, venous infiltration, and
advanced TNM tumor stage. Survival analysis demonstrated that Tbx3 expression was… More >
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