WEIGANG XIU1,#, XINGYU LIU1,2,#, KAIXIN HU1,2, QIN ZHANG3,*, HUASHAN SHI4,*
Oncology Research, Vol.32, No.10, pp. 1613-1621, 2024, DOI:10.32604/or.2024.047933
Abstract Elevated serum cholesterol metabolism is associated with a reduced risk of lung cancer. Disrupted cholesterol metabolism is evident in both lung cancer patients and tumor cells. Inhibiting tumor cell cholesterol uptake or biosynthesis pathways, through the modulation of receptors and enzymes such as liver X receptor and sterol-regulatory element binding protein 2, effectively restrains lung tumor growth. Similarly, promoting cholesterol excretion yields comparable effects. Cholesterol metabolites, including oxysterols and isoprenoids, play a crucial role in regulating cholesterol metabolism within tumor cells, consequently impacting cancer progression. In lung cancer patients, both the cholesterol levels in the… More >
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