Lian Zheng, Zhen-Jie Guan, Wen-Ting Pan, Tian-Feng Du, Yu-Jia Zhai, Jia Guo
Oncology Research, Vol.26, No.3, pp. 483-494, 2018, DOI:10.3727/096504017X14941825760362
Abstract Oral submucous fibrosis (OSF) induced by chewing of the areca nut has been considered to be a precancerous lesion with a high probability of developing oral squamous cell carcinoma. Tanshinone (TSN) is the main
component extracted from Salvia miltiorrhiza, a traditional Chinese medicine, which was found to have diverse
pharmacological effects, such as anti-inflammatory and antitumor. In the current study, we aimed to identify
the inhibitory effects and the underlying mechanism of TSN on OSF progress. We found that treatment with
TSN inhibited the arecoline-mediated proliferation of primary human oral mucosal fibroblasts and reversed
the… More >
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