Bin Xiao*1, Chao Liu*†1, Bing-tong Liu*1, Xuan Zhang*, Rong-rong Liu*, Xue-Wu Zhang*
Oncology Research, Vol.23, No.6, pp. 311-320, 2015, DOI:10.3727/096504016X14567549091341
Abstract Previous studies have shown that 5,2',4'-trihydroxy-6,7,5'-trimethoxyflavone (TTF1) is the primary anticancer constituent of the traditional Chinese medicinal plant Sorbaria sorbifolia (SS), which has been applied to
treat cancer in China. In this study, we investigated the in vitro and in vivo antitumor effects and biological
mechanisms of small-molecule TTF1 nanoparticles (TTF1-NPs). The effects of TTF1-NPs on cell growth and
apoptosis were investigated using human hepatoma cells. The molecular changes associated with the effects of
TTF1-NPs were analyzed by immunocytochemistry and Western blot analysis. The in vivo effect of TTF1-NPs
was investigated using the HepG2 tumor xenograft More >
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