YONGJIAN HUANG, JINZHOU WANG, JIUHUA XU, NING RUAN^*

Oncology Research, Vol.32, No.11, pp. 1765-1776, 2024, DOI:10.32604/or.2024.045564 - 16 October 2024

Abstract Background: Despite significant advancements in the development of anticancer therapies over the past few decades, the clinical management of colorectal cancer remains a challenging task. This study aims to investigate the inhibitory effects of cancer-targeting liposomes against colorectal cancer. Materials and Methods: Liposomes consisting of 3β-[N-(N′, N′-dimethylamino ethane)carbamoyl]-cholesterol (DC-CHOL), cholesterol (CHOL), and dioleoylphosphatidylethanolamine (DOPE) at a molar ratio of 1:1:0.5 were created and used as carriers to deliver an apoptosis-inducing plasmid encoding the tumor necrosis factor-related apoptosis-inducing ligand (pTRAIL) gene, along with the toll-like receptor (TLR7) agonist Rsiquimod (R848). The rationale behind this design is that More > Graphic Abstract

Yuanjun Dai^1,2,*, Xin Wei¹, Baohua Li¹, Cong Wang¹, Kunju Shi¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.2, pp. 337-348, 2024, DOI:10.32604/fdmp.2023.042434 - 14 December 2023

Abstract To study the impact of the trailing-edge wear on the vibrational behavior of wind-turbine blades, unworn blades and trailing-edge worn blades have been assessed through relevant modal tests. According to these experiments, the natural frequencies of trailing-edge worn blades −1, −2, and −3 increase the most in the second to fourth order, the fifth order increases in the middle, and the first order increases the least. The damping ratio data indicate that, in general, the first five-order damping ratios of trailing-edge worn blades −1 and trailing-edge worn blades −2 are reduced, and the first five-order More >

Abdulaziz Attaallah¹, Khalil al-Sulbi², Areej Alasiry³, Mehrez Marzougui³, Neha Yadav⁴, Syed Anas Ansar^5,*, Pawan Kumar Chaurasia⁴, Alka Agrawal⁴

Intelligent Automation & Soft Computing, Vol.37, No.2, pp. 1853-1875, 2023, DOI:10.32604/iasc.2023.039761 - 21 June 2023

Abstract Connected and autonomous vehicles are seeing their dawn at this moment. They provide numerous benefits to vehicle owners, manufacturers, vehicle service providers, insurance companies, etc. These vehicles generate a large amount of data, which makes privacy and security a major challenge to their success. The complicated machine-led mechanics of connected and autonomous vehicles increase the risks of privacy invasion and cyber security violations for their users by making them more susceptible to data exploitation and vulnerable to cyber-attacks than any of their predecessors. This could have a negative impact on how well-liked CAVs are with… More >

Jinghua Wang¹, Leian Zhang¹, Xuemei Huang^1,*, Jinfeng Zhang², Chengwei Yuan¹

Energy Engineering, Vol.119, No.1, pp. 407-418, 2022, DOI:10.32604/EE.2022.016439 - 22 November 2021

Abstract Transverse crack often occurs in the trailing edge region of the blade when subjected to the excessive edgewise fatigue load. In this paper a refined model was established through local mesh refinement methods in order to investigate the initiation mechanism of crack and its extension in blade trailing edge. The material stress around the crack in trailing edge region under different thicknesses is calculated based on the fracture mechanics theory. The factors affecting the fatigue robustness of blade trailing edge are concluded by investigating the results of finite element analysis and coupons test. Compared with More >

Dong Wang^1,*, Siwei Chen¹, Weigong Zhang¹, Danjie Du²

CMC-Computers, Materials & Continua, Vol.71, No.1, pp. 1837-1848, 2022, DOI:10.32604/cmc.2022.023033 - 03 November 2021

Abstract It is different for the liquid tank semi-trailer to keep roll stability during turning or emergency voidance, and that may cause serious accidents. Although the scholars did lots of research about the roll stability of liquid tank semi-trailer in theory by calculating and simulation, how to make an effective early warning of rollover is still unsolved in practice. The reasons include the complex driving condition and the difficulty of the vehicle parameter obtaining. The feasible method used currently is evaluating the roll stability of a liquid tank semi-trailer by the lateral acceleration or the attitude… More >

D. O. Redchyts¹, E. A. Shkvar^{2, *}, S. V. Moiseienko³

FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.1, pp. 91-103, 2020, DOI:10.32604/fdmp.2020.07933 - 01 February 2020

Abstract A method to evaluate the properties of turbulent flow in proximity to the vehicle and close to the ground surface has been elaborated. Numerical simulations have been performed on the basis of the Unsteady Reynolds-averaged Navier-Stokes equations (URANS) written with respect to an arbitrary curvilinear coordinate system. These equations have been solved using the Spalart-Allmaras differential one-parametric turbulence model. The method of artificial compressibility has been used to improve the coupling of pressure and velocity in the framework of a finite volume approach. Time-averaged distributions of pressure fields, velocity components, streamlines in the entire area… More >

Jinsong Dong^a, Hongwei Zhang^a, Ronghui Zhang^b,*, Xiaohong Jin^c, Fang Chen^d

Intelligent Automation & Soft Computing, Vol.24, No.3, pp. 563-570, 2018, DOI:10.31209/2018.100000023

Abstract The research on braking performance a of tractor-semitrailer is a hard and difficult point in the field of vehicle reliability and safety technology. In this paper, the tire braking model and the dynamic characteristic model of the brake torque with the variable of the controlling air pressure were established. We also established a nonlinear kinematic model of the tractor-semitrailer when it brakes on a curve. The parameters and variables of the model were measured and determined by the road experiment test. The optimal control strategy for the tractor-semitrailer based on the optimal slipping ratio was More >

Su-Hoon Lee, Suh-Kyung Hyun, Hak-Bong Kim, Chi-Dug Kang, Sun-Hee Kim

Oncology Research, Vol.24, No.6, pp. 495-509, 2016, DOI:10.3727/096504016X14685034103950

Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a poor prognosis and high recurrence rate. In the present study, we identified CD133, one of the markers of cancer stem cells, as a novel molecular target of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In four human HCC cell lines established from primary HCC tumors, we found that CD133-high human liver cancer stem-like cells (CD133^hi) derived from the SNU-475 cell line were highly susceptible to TRAIL compared to other HCC cell lines with a small population of CD133. CD133^hi SNU-475 cells showed upregulation of TRAIL… More >

Torres¹ YA, CA Busso¹, OA Montenegro², HD Giorgetti², HD Rodríguez², D Bentivegna³

Phyton-International Journal of Experimental Botany, Vol.79, pp. 195-198, 2010, DOI:10.32604/phyton.2010.79.195

Abstract Osmotic adjustment has been recognized to be an important adaptive response to water stress in higher plants. Although Leymus cinereus cv. “Trailhead” is reputedly a very drought-tolerant rangeland plant, its ability to adjust osmotically in the field has not previously been reported. This study examined the occurrence or not of osmotic adjustment in field-grown plants of Leymus cinereus cv. “Trailhead” during late spring in an arid zone of Patagonia. Plants of this species had been established in the field three years before. With this purpose, leaf laminae of this species were collected and pressure-volume curves made. Results More >