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  • Open Access

    PROCEEDINGS

    Flow and Heat Transfer Performance of Porous Heat Exchanger Based on Conformal Geometry Design

    Yijin Zhang, Panding Wang*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.2, pp. 1-1, 2025, DOI:10.32604/icces.2025.011144

    Abstract As a type of porous material with high porosity and a large surface-area-to-volume ratio, triply periodic minimal surface (TPMS) structures divide space into two non-interconnected parts. This increases the contact area while maintaining full connectivity and smoothness, which helps reduce flow resistance, making it naturally suited for applications in heat exchange designs. The advancement of additive manufacturing (AM) technology has contributed to the development of TPMS-based heat exchangers. However, due to the complexity of fluid heat exchanger designs, developing effective representations, models, and optimization schemes for TPMS structures in multi-fluid heat exchange problems is very… More >

  • Open Access

    ARTICLE

    Research on Variable Condition Properties and Experimental Verification of a Variable Cross-Section Scroll Expander

    Junying Wei1, Guangxian Yin2, Jihao Zhang2, Wenwen Chang2, Chenrui Zhang2, Zhengyi Li1, Long Chang1, Minghan Peng3,*

    Frontiers in Heat and Mass Transfer, Vol.23, No.4, pp. 1185-1201, 2025, DOI:10.32604/fhmt.2025.067244 - 29 August 2025

    Abstract The scroll expander, as the core component of the micro-compressed air energy storage and power generation system, directly affects the output efficiency of the system. Meanwhile, the scroll profile plays a central role in determining the output performance of the scroll expander. In this study, in order to investigate the output characteristics of a variable cross-section scroll expander, numerical simulation and experimental studies were conducted by using Computational Fluid Dynamics (CFD) methods and dynamic mesh techniques. The impact of critical parameters on the output performance of the scroll expander was analyzed through the utilization of… More >

  • Open Access

    ARTICLE

    Mechanical Performance of Additive Manufactured TPMS Lattice Structures Based on Topology Optimization

    Yizhou Wang1, Qinghai Zhao2,*, Guoqing Li1, Xudong Li1

    CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.1, pp. 763-789, 2025, DOI:10.32604/cmes.2025.067363 - 31 July 2025

    Abstract Lattice structures have attracted extensive attention in the field of engineering materials due to their characteristics of lightweight and high strength. This paper combines topology optimization with additive manufacturing to investigate how pore shape in Triply Periodic Minimal Surface (TPMS) structures affects mechanical properties and energy absorption performance. The periodic lattice structures (Triangle lattice, rectangle lattice and Rectangle lattice) and aperiodic mixed structures are designed, including a variety of lattice structures such as circle-circle and triangle-triangle (CCTT), triangle-triangle and rectangle-rectangle (TTRR), circle-circle and rectangle-rectangle (CCRR), triangle-circle-circle-triangle (TCCT), rectangle-triangle-triangle-rectangle (RTTR) and rectangle-circle-circle-rectangle (RCCR). The anisotropy of… More >

  • Open Access

    ARTICLE

    Digital Distraction or Creative Catalyst? Parental Smartphone Use and Adolescent Creativity among Chinese Vocational Students

    Min Qu1,2,#, Xiumei Chen1,3,#, Yue Zhou4, Xuelian Wang5,6,*, I-Hua Chen7,8,*

    International Journal of Mental Health Promotion, Vol.27, No.7, pp. 1029-1044, 2025, DOI:10.32604/ijmhp.2025.065876 - 31 July 2025

    Abstract Background: Despite growing research on parental technology use and its impacts on adolescent development, the influence of parental smartphone behavior on creativity remains understudied. This study addresses this gap by examining how parental phubbing affects adolescent creativity, exploring both direct and indirect pathways through creative self-efficacy as a mediator and problematic smartphone use (PSU) as a moderator. Methods: A total of 9111 Chinese vocational school adolescents (60.3% male; mean age = 16.88 years) were recruited via convenience sampling. Participants completed validated self-report questionnaires assessing creativity, parental phubbing, creative self-efficacy, and PSU. A moderated mediation model… More >

  • Open Access

    ARTICLE

    Greenhouse Gas Payback of a Solar Photovoltaic System in Northeast Brazil: Effects of the Application of a Solar Coating

    Luiz Felipe Souza Fonseca1, Heitor do Nascimento Andrade1, João Marcelo Fernandes Gualberto de Galiza2, Raphael Abrahão1, Hamid Boleydei3, Silvia Guillén-Lambea4, Monica Carvalho1,*

    Energy Engineering, Vol.122, No.8, pp. 3265-3283, 2025, DOI:10.32604/ee.2025.066218 - 24 July 2025

    Abstract The application of different coatings on solar photovoltaic (PV) panels can be an efficient solution to increase performance and further mitigate the emission of greenhouse gases. This study uses the Life Cycle Assessment (LCA) methodology and the environmental payback concept to analyze the effects of the application of a nano-silica coating on a solar PV system installed in the Brazilian Northeast. Firstly, an uncoated reference 16.4 MW PV system is designed, and the detailed inventory is presented (PV panels, supporting structure, inverters, junction boxes, cables, transportation, maintenance and operation—including the replacement of equipment). The results… More > Graphic Abstract

    Greenhouse Gas Payback of a Solar Photovoltaic System in Northeast Brazil: Effects of the Application of a Solar Coating

  • Open Access

    ARTICLE

    Identifying ATP-Binding Cassette Member B5 as a New Biomarker for Oral Squamous Cell Carcinoma

    Li Yu1,2,3, Xiaoyan Zhang1,2, Yan Feng1,4, Xinyue Liao1,4, Tiejun Zhou5, Hang Si1,4, Yun Feng1,4, Decai Wang6,*, Yongxian Lai1,7,*

    Oncology Research, Vol.33, No.8, pp. 2037-2053, 2025, DOI:10.32604/or.2025.064276 - 18 July 2025

    Abstract Background: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy with a low five-year survival rate. ATP-binding cassette subfamily B member 5 (ABCB5) has been linked to tumorigenesis. However, its role in inducing OSCC remains unclear. Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blot, and immunocytochemistry (ICC) were performed to examine the level of ABCB5 in OSCC (CAL27 and HSC-3) and human oral keratinocyte (HOK). ABCB5 was knocked down in CAL27 cells using ABCB5-specific small interfering RNA (ABCB5 siRNA), and its contribution to migration, invasion, and epithelial-mesenchymal transition (EMT),… More >

  • Open Access

    ARTICLE

    Synergistic anticancer and antibacterial effects of novel regimens of phytopolyphenols and repurposing drugs on cultured cells

    YA-LING YEH1, YING-JAN WANG1, SHOEI-YN LIN-SHIAU2,3,*

    Oncology Research, Vol.33, No.7, pp. 1781-1796, 2025, DOI:10.32604/or.2025.063717 - 26 June 2025

    Abstract Background: The increasing incidence of cancers and infectious diseases worldwide presents a significant public health challenge that requires immediate intervention. Our strategy to tackle this issue involves the development of pharmaceutical formulations that combine phytopolyphenols (P), targeted drugs (T), and metal ions (M), collectively referred to as PTM regimens. The diverse pharmacological properties of PTM regimens are hypothesized to effectively reduce the risk factors associated with both cancers and infectious diseases. Methods: The effects of the pharmaceutical agents on the proliferation of cultured cancer cells and pathogens were assessed after 72 h and 48 h,… More >

  • Open Access

    ARTICLE

    Single-Cell Transcriptomic Profiling Reveals KRAS/TP53-Driven Neutrophil Reprogramming in Luad: A Multi-Gene Prognostic Model and Therapeutic Targeting of RHOV

    Yinghui Ye1,#, Yulou Luo2,#, Yutian Sun3, Yujie Zhang1, Jiaxin Lin4, Ziling Yang5, Anping Xu6,*, Bei Xue1,*

    Oncology Research, Vol.33, No.6, pp. 1383-1404, 2025, DOI:10.32604/or.2025.062584 - 29 May 2025

    Abstract Objectives: The tumorigenic progression of Lung adenocarcinoma (LUAD), the predominant NSCLC subtype, is predominantly driven by co-occurring mutations in KRAS proto-oncogene (KRAS)/Tumor protein p53 (TP53). However, their impact on tumor microenvironment (TME) heterogeneity, particularly neutrophil dynamics, remains poorly understood. This present study aims to elucidate how KRAS/TP53 mutations reprogram the TME and develop a neutrophil-centric prognostic signature for LUAD. Methods: Leveraging single-cell RNA sequencing data and transcriptome data, neutrophil subpopulations were identified using Seurat and CellChat R packages, with trajectory analysis via Monocle2 R package. High-dimensional weighted gene co-expression network analysis (hdWGCNA), univariate Cox regression,… More >

  • Open Access

    ARTICLE

    Comparative assessment of antitumor effects between doxorubicin and mitochondria-targeted doxorubicin in combination with radiotherapy

    JIANMIAO YANG1,2,#, XIAOYAN SUN3,#, TIANTIAN WANG1, HAIQING ZHONG1,3, MIN HAN1,3, WUPING SHUAI4,5,6,*, DONGHANG XU1,*

    Oncology Research, Vol.33, No.6, pp. 1423-1436, 2025, DOI:10.32604/or.2025.058997 - 29 May 2025

    Abstract Objectives: Triphenylphosphine (TPP) and Doxorubicin (DOX) were conjugated to obtain Triphenylphosphine-Doxorubicin (TPP-DOX), which was applied in tumor cells for enhancement of DOX in mitochondria targeting. The study focused on investigating the anti-tumor effect of TPP-DOX in combination with radiotherapy throughout in vitro and in vivo studies. Methods: TPP-DOX was synthesized using the carbodiimide method. In vitro experiments were conducted with 4T1 cells (mouse breast cancer cell line) to assess apoptosis induction, mitochondrial targeting, reactive oxygen species (ROS) production, and mitochondrial membrane potential. The research evaluates the effects of TPP-DOX, DOX, and their combinations with radiotherapy. A nude mouse… More > Graphic Abstract

    Comparative assessment of antitumor effects between doxorubicin and mitochondria-targeted doxorubicin in combination with radiotherapy

  • Open Access

    ARTICLE

    Heat Transfer Characterization of TPMS Heat Exchangers Applied to the Aerospace Field

    Nan Li1,2, Miao Wang1, Jingwen Zhao1, Kechun Sun1, Cheng Bi3, Mu Du4,*, Ersheng You5, Mingyang Yang6,*

    Frontiers in Heat and Mass Transfer, Vol.23, No.2, pp. 601-614, 2025, DOI:10.32604/fhmt.2025.061192 - 25 April 2025

    Abstract In exploring hypersonic propulsion, precooler combined engines require the development of lightweight, efficient, and compact heat exchangers (HX). As additive manufacturing technology continues to progress, triply periodic minimal surface (TPMS) structures, characterized by exceptionally high surface area to volume ratios and intricate geometric structures, have demonstrated superior heat transfer performance. This research examines the thermal-hydraulic (TH) behavior of FKS and Diamond as heat transfer structures under different Reynolds numbers through numerical simulations. The Nusselt number for FKS is 13.2%–17.6% higher than Diamond, while the friction factor for FKS is approximately 18.8%–29.3% higher. A detailed analysis More >

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