Stefano Dore¹, Matteo Sacchi¹, Antonio Pinna¹, Giuseppe Palmieri^2,3, Panagiotis Paliogiannis^4,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071831 - 19 January 2026

Abstract Uveal melanoma (UM) is the most common intraocular cancer, with approximately 5.2 individuals per million affected annually in the United States. It represents approximately 3% of the global malignant melanoma cases, accounting for 80% of the overall noncutaneous melanomas. Clinically, it remains silent in about 30% of the cases; when symptomatic, it generally causes metamorphopsia (painless loss or distortion of vision) and/or photopsia (flashing or flickering of light in the visual field). Discoloration of the iris, astigmatism, glaucoma, and even blindness are other, less common clinical manifestations. Several pathophysiological mechanisms underlie the development of UM.… More >

Kamila Mozga¹, Olga Synowiecka¹, Igor Rydzyk¹, Anna Marek¹, Ewelina Wieczorek¹, Alicja Petniak^2,*, Paulina Gil-Kulik²

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070505 - 19 January 2026

Abstract Objectives: Immunotherapy based on immune checkpoint blockade (ICB) has become a key treatment for melanoma. However, the increasing number of cases of melanoma resistant to immunotherapy highlights the need to develop methods to overcome this resistance. This study aims to collect the most recent information on melanoma immunotherapy, discuss potential strategies to overcome resistance to immunotherapy, and identify areas that require further analysis. Methods: To achieve this goal, scientific publications from 2021–2024 available in PubMed and Google Scholar databases were analyzed. The databases were searched using the following terms: “melanoma”, “immunotherapy”, “Immune Checkpoint Blockade”, and More >

Urszula Częścik^1,2,#, Martyna Gryglas³, Arkadiusz Szterk⁴, Sylwia Flis^3,#,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.067449 - 19 January 2026

Abstract Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer-related deaths, accounting for approximately 10% of all cancer cases. By 2050, CRC incidence is expected to rise substantially, driven by population aging and greater exposure to risk factors in developing countries. Despite advances in medicine and pharmacy, the effectiveness of available treatments remains limited, underscoring the urgent need for innovative therapeutic strategies. This review summarizes and critically evaluates currently available CRC therapies and explores new emerging directions. Particular attention is given to the role of immunotherapy, targeted therapies,… More >

Hailong Wang¹, Minglei Duan², Lu Yao³, Hao Li^1,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072942 - 12 January 2026

Abstract In image analysis, high-precision semantic segmentation predominantly relies on supervised learning. Despite significant advancements driven by deep learning techniques, challenges such as class imbalance and dynamic performance evaluation persist. Traditional weighting methods, often based on pre-statistical class counting, tend to overemphasize certain classes while neglecting others, particularly rare sample categories. Approaches like focal loss and other rare-sample segmentation techniques introduce multiple hyperparameters that require manual tuning, leading to increased experimental costs due to their instability. This paper proposes a novel CAWASeg framework to address these limitations. Our approach leverages Grad-CAM technology to generate class activation… More >

Haotian Zhang, Jing Li^*, Ming Zhu, Zhiyong Zhao, Hongli Su, Liming Sun

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072381 - 12 January 2026

Abstract In the wireless energy transmission service composition optimization problem, a key challenge is accurately capturing users’ preferences for service criteria under complex influencing factors, and optimally selecting a composition solution under their budget constraints. Existing studies typically evaluate satisfaction solely based on energy transmission capacity, while overlooking critical factors such as price and trustworthiness of the provider, leading to a mismatch between optimization outcomes and user needs. To address this gap, we construct a user satisfaction evaluation model for multi-user and multi-provider scenarios, systematically incorporating service price, transmission capacity, and trustworthiness into the satisfaction assessment… More >

Kai Gui^1,#, Tianyi Yang^1,#, Chengying Xiong¹, Yue Wang¹, Zhiqiang He¹, Wuxian Li^2,3,*, Min Tang^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070143 - 30 December 2025

Abstract Objectives: The mechanism by which specific tumor subsets in colorectal cancer (CRC) use alternative metabolic pathways, particularly those modulated by hypoxia and fructose, to alter the tumor microenvironment (TME) remains unclear. This study aimed to identify these malignant subpopulations and characterize their intercellular signaling networks and spatial organization through an integrative multi-omics approach. Methods: Leveraging bulk datasets, single-cell RNA sequencing, and integrative spatial transcriptomics, we developed a prognostic model based on hypoxia-and fructose metabolism-related genes (HFGs) to delineate tumor cell subpopulations and their intercellular signaling networks. Results: We identified a specific subset of stanniocalcin-2 positive (STC2+)… More > Graphic Abstract

Anushka Ghosh, Maria J. D’Amico, Yash B. Shah, Whitney R. Smith, Mihir S. Shah, Costas D. Lallas, Alana M. Murphy^*

Canadian Journal of Urology, Vol.32, No.6, pp. 627-632, 2025, DOI:10.32604/cju.2025.067575 - 30 December 2025

Abstract Background: Genitourinary syndrome of menopause (GSM) is a highly prevalent, underdiagnosed condition that can significantly impair quality of life (QoL). This study evaluates real-world treatment trends for GSM to better understand current management practices and highlight ongoing gaps in care. The background is in a different font than the rest of the abstract. Methods: We queried the TriNetX database for patients with a diagnosis of postmenopausal atrophic vaginitis (ICD N95.2) and treatment information from 2004–2024. A combination of RxNorm and International Classification of Diseases-10 (ICD) codes was used to classify disease and treatment type, including… More >

Jordan L. Mendelson^1,*, Jordan Kassab¹, Phillip Westbrook¹, Katie Yang², Anthony Corcoran¹

Canadian Journal of Urology, Vol.32, No.6, pp. 673-676, 2025, DOI:10.32604/cju.2025.063770 - 30 December 2025

Abstract Stereotactic body radiotherapy (SBRT) for prostate cancer is a generally well-tolerated treatment but can rarely lead to complications such as fistula formation. We report a 69-year-old male on maintenance ibrutinib for chronic lymphocytic leukemia who developed a fistula between his bladder and vas deferens in the setting of ascending scrotal infection. Despite his prior history of SBRT, the fistula was successfully treated with minimally invasive measures. A combination of abscess debridement, urinary diversion, and broad-spectrum antibiotics helped to achieve fistula resolution. The unique presentation described herein highlights the importance of early aggressive intervention for source More >

Pooja Yadav^1,*, Ramin Farnood², Vivek Kumar^1,*

Journal of Polymer Materials, Vol.42, No.4, pp. 1181-1197, 2025, DOI:10.32604/jpm.2025.072564 - 26 December 2025

Abstract Heavy metal contamination in water sources is a widespread global concern, particularly in developing nations, with various treatment approaches under extensive scientific investigation. In the present study, we fabricated electrospun composite polyvinylidene fluoride (PVDF) nanofibrous membranes exhibiting hierarchical surface roughness and superhydrophobicity for the removal of heavy metal ions via vacuum membrane distillation (VMD) process. The membranes were prepared by incorporating optimized dosing of silica nanoparticles, followed by a two-step membrane modification approach. These membranes exhibited notable characteristics, including elevated water contact angle (152.8 ± 3.2°), increased liquid entry pressure (127 ± 6 kPa), and… More > Graphic Abstract

Huaao Jiang^#, Bianyifan Xu^#, Yang Gui, Ying Xia, Xu Yin, Chao Zhang, Yue Meng, Xin Yu, Yan Wang, Hongmei Xia^*

Journal of Polymer Materials, Vol.42, No.4, pp. 993-1033, 2025, DOI:10.32604/jpm.2025.071740 - 26 December 2025

Abstract Traditional Chinese medicine (TCM) has a long history and is widely used to prevent and treat various diseases. With the development of modern technology, an increasing number of active ingredients—such as curcumin, berberine, and baicalin—have been identified and validated within TCM. Concurrently, the emergence of nanotechnology has led to the discovery of numerous nanomedicines based on the self-assembly of active ingredients from TCM. Polymer materials can enhance the bioavailability of these active compounds and reduce their toxic side effects. Moreover, compared to synthetic polymers, natural polymer materials offer advantages such as non-toxicity and high biosafety… More >