XULONG SUN^1,#, WENTAO DING^2,#, CHAO JIANG³, ZHIAN FANG^4,*

BIOCELL, Vol.48, No.7, pp. 1071-1079, 2024, DOI:10.32604/biocell.2024.050519

Abstract Introduction: Hepatocellular carcinoma (HCC), a prevalent malignancy, poses significant challenges with high tumor heterogeneity and poor prognosis. MicroRNAs (miRNAs) play a pivotal role in hepatocarcinogenesis. Although abnormalities in microRNA-557 (miR-557) expression have been implicated in various cancer types, its role in HCC remains unclear. Therefore, there is a need to explore the function of microRNA-557 in HCC. Methods: Candidate miRNAs were identified through screening in GSE108724 and GSE20077. Real-time PCR was employed to analyze the expression level of miR-557 in hepatoma cell lines and tissues. Cell viability and migration assays were applied to assess the… More > Graphic Abstract

YAN-NAN LI^1,#, YUN-HONG XIU^2,#, YAN-JUN TANG³, JING-LONG CAO¹, WEN-SHUANG HOU¹, AN-QI WANG¹, TIAN-ZHU LI^4,*, CHENG-HAO JIN^1,3,5,*

BIOCELL, Vol.48, No.7, pp. 1055-1069, 2024, DOI:10.32604/biocell.2024.050515

Abstract Objectives: Sciadopitysin (SP) is a flavonoid in Ginkgo biloba that exhibits various pharmacological activities. This study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma (HCC) cells. Methods: Network pharmacology was used for target prediction analysis. Cell Counting Kit-8 (CCK-8) assay was used to test the cell viability. Flow cytometry was used to test the cell cycle distribution, apoptosis status, and reactive oxygen species (ROS) levels. Transwell and wound-healing assay was used to test the migration effect of SP on HepG2 cells. Western Blot assay was used to… More > Graphic Abstract

JIAOE SHENG¹, ZUMIN YI², SANSHAN HE¹, QINGCHAO WU¹, XIA HUANG¹, GUOQING YAN¹, YUFANG DAI^1,*, LINCHONG SU^1,*

BIOCELL, Vol.48, No.7, pp. 1095-1104, 2024, DOI:10.32604/biocell.2024.028421

Abstract Introduction: Cholic acid (CA) is a natural steroid useful in treating chronic bronchitis and cholecystitis. On the other hand, its potential impact on osteoarthritis (OA) is unknown. Objective: Using an in vitro and in vivo osteoarthritis model, we sought to assess the chondroprotective properties of CA. Methods: We employed the Cell Counting Kit-8 to measure the impact of CA on chondrocyte activity to assess the toxicity of the cells. Multiple molecular biology experimental techniques were used to investigate potential signaling pathways that CA may use to prevent inflammation and give chondrocytes protection. Furthermore, how CA affects the OA… More >

Yuetan Wang^1,2,*, Xianle Yan^1,2, Lili Liu^1,2, Xiran Lu^1,2, Lan Luo^1,2, Xiaobin Ding^1,2,*

International Journal of Mental Health Promotion, Vol.26, No.6, pp. 429-438, 2024, DOI:10.32604/ijmhp.2024.050445

Abstract Social anxiety (SA) is a prevalent mental health issue among adolescents, and vulnerable narcissism (VN) can exacerbate this condition. This study aims to investigate the impact of vulnerable narcissism on social anxiety in adolescents, specifically focusing on the mediating effects of self-concept clarity (SCC) and self-esteem (SE) in the relationship between vulnerable narcissism and social anxiety. Through cluster sampling, a questionnaire survey was conducted among 982 students from three secondary schools in two provinces. The data was analyzed using structural equation modeling (SEM). The results revealed that there was a significant negative correlation between vulnerable More >

He Zhong^1,*, Yaping Zhou², Chenwei Liu³, Yintao Cao²

International Journal of Mental Health Promotion, Vol.26, No.6, pp. 481-489, 2024, DOI:10.32604/ijmhp.2024.049408

Abstract Childhood maltreatment, as a typical early adverse environment, is known to have a negative impact on one’s life satisfaction. Mindfulness, on the other hand, may serve as a protective factor. This study explored the mediating role of mindfulness and its related variables–positive thoughts, psychological resilience and self-esteem. In order to testify the mechanism, we administered Childhood Trauma Questionnaire (CTQ), Satisfaction with Life Scale (SWLS), Mindful Attention Awareness Scale (MAAS), Connor–Davidson Resilience Scale (CD-RISC) and Rosenberg Self-Esteem Scale (RSES) to a non-clinical sample of Chinese university students (N = 1021). The results indicated that positive thoughts More >

Shuai Lv^1,2, Zhaojun Chen^2,3, Jian Mao⁴, Hui Wang^2,5,*, Peibo Wu², Yujuan Hai¹

International Journal of Mental Health Promotion, Vol.26, No.6, pp. 491-498, 2024, DOI:10.32604/ijmhp.2024.048917

Abstract Objectives: To explore the relationship between college students’ self-esteem (SE) and their social phobia (SP), as well as the mediating role of fear of negative evaluation (FNE) and the moderating effect of perfectionism. Methods: A convenience sampling survey was carried out for 1020 college students from Shandong Province of China, utilizing measures of college students’ self-esteem, fear of negative evaluation, perfectionism, and social phobia. Data analysis was performed using the SPSS PROCESS macro. Results: (1) college students’ self-esteem significantly and negatively predicts their social phobia (β = −0.31, t = −10.10, p < 0.001); (2) fear of More >

Zhengfeng Lai, Dongmei Lian, Shaoping Zhang, Yudong Ju, Bizhen Lin, Yunfa Yao, Songhai Wu, Jianji Hong, Zhou Li^*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1143-1158, 2024, DOI:10.32604/phyton.2024.051207

Abstract The cytokinin oxidase/dehydrogenase (CKX) enzyme is essential for controlling the fluctuating levels of endogenous cytokinin (CK) and has a significant impact on different aspects of plant growth and development. Nonetheless, there is limited knowledge about CKX genes in tomato (Solanum lycopersicum L.). Here we performed genome-wide identification and analysis of nine SlCKX family members in tomatoes using bioinformatics tools. The results revealed that nine SlCKX genes were unevenly distributed on five chromosomes (Chr.1, Chr.4, Chr.8, Chr.10, and Chr.12). The amino acid length, isoelectric points, and molecular weight of the nine SlCKX proteins ranged from 453 to 553, 5.77… More >

Cinthia T. Lucero¹, María de los Á. Ruíz², Fabiola Pagliero¹, Carolina Castaño¹, Mariela L. Ambrosino¹, Graciela S. Lorda^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1081-1099, 2024, DOI:10.32604/phyton.2024.050762

Abstract Beneficial microbes can improve soil health by promoting soil structure, nutrient cycling, and disease suppression. In addition, a wide array of rhizospheric microbes are responsible for producing metabolically active compounds including various types of plant growth regulators. So, microbial biodiversity studies could contribute to the improvement of agricultural practices in deprived areas, such as the Pampean semiarid region. The vast majority of studies conducted on endophytic microorganisms have focused on intensive crop legume species. In contrast, little attention has been paid to microorganisms of native legumes, whose ecology is not directly affected by human action.… More >

Abdul Momin¹, Amana Khatoon^1,*, Wajahat Khan¹, Dilsat Bozdoğan Konuşkan², Muhammad Mudasar Aslam³, Muhammad Jamil⁴, Shafiq Ur Rehman⁵, Baber Ali⁶, Alevcan Kaplan⁷, Sana Wahab⁸, Muhammad Nauman Khan^9,*, Sezai Ercisli^10,11, Mohammad Khalid Al-Sadoon¹²

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1117-1128, 2024, DOI:10.32604/phyton.2024.048994

Abstract Sprouts are ready-to-eat and are recognized worldwide as functional components of the human diet. Recent advances in innovative agricultural techniques could enable an increase in the production of healthy food. The use of light-emitting diode (LED) in indoor agricultural production could alter the biological feedback loop, increasing the functional benefits of plant foods such as wheat and lentil sprouts and promoting the bioavailability of nutrients. The effects of white (W), red (R), and blue (B) light were investigated on the growth parameters and nutritional value of wheat and lentil sprouts. In the laboratory, seeds were… More >

Huiyan Zhao¹, Xuezhong Chen¹, Zhijian Hu^2,*, Man Chen¹, Bo Xiong³, Jianying Yang¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1313-1330, 2024, DOI:10.32604/fdmp.2024.048840

Abstract Using the typical characteristics of multi-layered marine and continental transitional gas reservoirs as a basis, a model is developed to predict the related well production rate. This model relies on the fractal theory of tortuous capillary bundles and can take into account multiple gas flow mechanisms at the micrometer and nanometer scales, as well as the flow characteristics in different types of thin layers (tight sandstone gas, shale gas, and coalbed gas). Moreover, a source-sink function concept and a pressure drop superposition principle are utilized to introduce a coupled flow model in the reservoir. A… More > Graphic Abstract