CHANG CHEN1,#, LIMIN QIAO2,#, KAIJUN GUO1, YINGQIU WANG1, MENGYI YUAN3, BOFAN FU4, XIAOBO GAO3, HEMIN NI1, LONGFEI XIAO1,*, XIANGGUO WANG1,*
BIOCELL, Vol.46, No.11, pp. 2415-2423, 2022, DOI:10.32604/biocell.2022.021510
- 07 July 2022
Abstract Endometritis affects the reproductive capacity of dairy cows and leads to serious economic losses in dairy farming. Clarification of the pathogenesis of endometritis is necessary to improve the reproductive efficiency of dairy cows. Exosomes and their miRNAs have been proven to play an important role in inflammatory regulation. Exosomal miR-218 is a differentially expressed miRNA found in endometrial epithelial cells (EECs) under endometrial inflammation. Therefore, we investigated the expression of miR-218 in the uterine tissue of dairy cows, lipopolysaccharide (LPS) treated EECs, exosomal vesicles, and regulation of exosomal miR-218 by targeting TGIF-2 inducible factor homology… More >
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