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  • Open Access

    ARTICLE

    Predicting Rock Burst in Underground Engineering Leveraging a Novel Metaheuristic-Based LightGBM Model

    Kai Wang1, Biao He2,*, Pijush Samui3, Jian Zhou4

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 229-253, 2024, DOI:10.32604/cmes.2024.047569

    Abstract Rock bursts represent a formidable challenge in underground engineering, posing substantial risks to both infrastructure and human safety. These sudden and violent failures of rock masses are characterized by the rapid release of accumulated stress within the rock, leading to severe seismic events and structural damage. Therefore, the development of reliable prediction models for rock bursts is paramount to mitigating these hazards. This study aims to propose a tree-based model—a Light Gradient Boosting Machine (LightGBM)—to predict the intensity of rock bursts in underground engineering. 322 actual rock burst cases are collected to constitute an exhaustive rock burst dataset, which serves… More >

  • Open Access

    ARTICLE

    Synthesis and Characterization of Bisphenol-C Epoxy Crotonate and Its Fiber-Reinforced Composites

    PARSOTAM H. PARSANIA1,*, JIGNESH V. PATEL2, JIGNESH P. PATEL3

    Journal of Polymer Materials, Vol.40, No.3-4, pp. 271-284, 2023, DOI:10.32381/JPM.2023.40.3-4.9

    Abstract Bisphenol-C epoxy crotonate resin was synthesized by reacting 8.09g epoxy resin of bisphenolC, and 2.15g crotonic acid using 25 mL 1,4-dioxane as a solvent, and 1 mL triethylamine as a catalyst at reflux temperature for 1-6 h. Solid epoxy crotonate (ECCR) is highly soluble in common organic solvents. ECCR was characterized by its acid (24.5-1.5 mg KOH/g) and hydroxyl (504.5-678.4 mg KOH/g) values. The structure of ECCR is supported by FTIR and 1 HNMR spectroscopic methods. A DSC endothermic transition at 229o C indicated melting followed by thermal polymerization of ECCR. ECCR is thermally stable up to 320o C and… More >

  • Open Access

    ARTICLE

    Enhancing ChatGPT’s Querying Capability with Voice-Based Interaction and CNN-Based Impair Vision Detection Model

    Awais Ahmad1, Sohail Jabbar1,*, Sheeraz Akram1, Anand Paul2, Umar Raza3, Nuha Mohammed Alshuqayran1

    CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3129-3150, 2024, DOI:10.32604/cmc.2024.045385

    Abstract This paper presents an innovative approach to enhance the querying capability of ChatGPT, a conversational artificial intelligence model, by incorporating voice-based interaction and a convolutional neural network (CNN)-based impaired vision detection model. The proposed system aims to improve user experience and accessibility by allowing users to interact with ChatGPT using voice commands. Additionally, a CNN-based model is employed to detect impairments in user vision, enabling the system to adapt its responses and provide appropriate assistance. This research tackles head-on the challenges of user experience and inclusivity in artificial intelligence (AI). It underscores our commitment to overcoming these obstacles, making ChatGPT… More >

  • Open Access

    ARTICLE

    LncRNA LOC103694972 promotes fibrosis of NRK-49F cells by regulating STAT3-dependent Smad/CTGF pathway via targeting miR-29c-3p

    YAN LI1, HUZHI CAI2, XIAOLING PENG3, YOUHUI LIU4, QINGYANG CHEN4, XIANGDONG LIN5, XINYU CHEN6,*

    BIOCELL, Vol.48, No.3, pp. 501-511, 2024, DOI:10.32604/biocell.2023.030854

    Abstract Background: Renal fibrosis is an important process in the development of chronic kidney disease. Understanding the pathogenesis and finding effective treatments for renal fibrosis is crucial. This study aims to investigate whether a newly discovered long non-coding RNA (lncRNA) called LOC103694972 could be a potential target for treating fibrosis of NRK-49F cells. Methods:: LncRNA Chip was used to identify differentially expressed lncRNAs between TGF-β1-induced NRK-49F cells and normal cells. The dual-luciferase assay confirmed the binding between miR-29c-3p and signal transducer and activator of transcription (STAT3), as well as between miR-29c-3p and lncRNA LOC103694972. Si-LOC103694972 and miR-29c-3p mimic were then transfected… More > Graphic Abstract

    LncRNA LOC103694972 promotes fibrosis of NRK-49F cells by regulating STAT3-dependent Smad/CTGF pathway via targeting miR-29c-3p

  • Open Access

    ARTICLE

    TGF-β-regulated different iron metabolism processes in the development and cisplatin resistance of ovarian cancer

    JIANFA WU1,2,#, QIANYI LIAO3,#, LI ZHANG1,2,#, SUQIN WU1,2,*, ZHOU LIU1,2,*

    Oncology Research, Vol.32, No.2, pp. 373-391, 2024, DOI:10.32604/or.2023.031404

    Abstract The impact of different iron metabolism processes (DIMP) on ovarian cancer remains unclear. In this study, we employed various gene chips and databases to investigate the role of DIMP in the initiation and development of ovarian cancer. cBioPortal was used to determine mutations in DIMP-associated genes in ovarian cancer. Kaplan-Meier plotter was used to examine the influence of DIMP on the prognosis of ovarian cancer. By analyzing 1669 serous ovarian cancer cases, we identified a range of mutations in iron metabolism genes, notably in those coding for the transferrin receptor (19%), melanotransferrin (19%), and ceruloplasmin (10%) in the iron import… More >

  • Open Access

    ARTICLE

    Surface Morphology and Thermo-Electrical Energy Analysis of Polyaniline (PANI) Incorporated Cotton Fabric

    Md. Shohan Parvez1,2, Md. Mustafizur Rahman1,3,*, Mahendran Samykano1, Mohammad Yeakub Ali4

    Energy Engineering, Vol.121, No.1, pp. 1-12, 2024, DOI:10.32604/ee.2023.027472

    Abstract With the exponential development in wearable electronics, a significant paradigm shift is observed from rigid electronics to flexible wearable devices. Polyaniline (PANI) is considered as a dominant material in this sector, as it is endowed with the optical properties of both metal and semiconductors. However, its widespread application got delineated because of its irregular rigid form, level of conductivity, and precise choice of solvents. Incorporating PANI in textile materials can generate promising functionality for wearable applications. This research work employed a straightforward in-situ chemical oxidative polymerization to synthesize PANI on Cotton fabric surfaces with varying dopant (HCl) concentrations. Pre-treatment using… More >

  • Open Access

    REVIEW

    Exploring the Latest Applications of OpenAI and ChatGPT: An In-Depth Survey

    Hong Zhang1,*, Haijian Shao2

    CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.3, pp. 2061-2102, 2024, DOI:10.32604/cmes.2023.030649

    Abstract OpenAI and ChatGPT, as state-of-the-art language models driven by cutting-edge artificial intelligence technology, have gained widespread adoption across diverse industries. In the realm of computer vision, these models have been employed for intricate tasks including object recognition, image generation, and image processing, leveraging their advanced capabilities to fuel transformative breakthroughs. Within the gaming industry, they have found utility in crafting virtual characters and generating plots and dialogues, thereby enabling immersive and interactive player experiences. Furthermore, these models have been harnessed in the realm of medical diagnosis, providing invaluable insights and support to healthcare professionals in the realm of disease detection.… More > Graphic Abstract

    Exploring the Latest Applications of OpenAI and ChatGPT: An In-Depth Survey

  • Open Access

    ARTICLE

    Cisplatin-induced activation of TGF-β signaling contributes to drug resistance

    SAYAKA IMATSUJI1,#, YUKIKO UJIE1,#, HIROYUKI ODAKE1, MASAYA IMOTO1,2, SUSUMU ITOH3, ETSU TASHIRO1,3,*

    Oncology Research, Vol.32, No.1, pp. 139-150, 2024, DOI:10.32604/or.2023.030190

    Abstract Growing evidence suggests an association between epithelial-mesenchymal transition (EMT), a hallmark of tumor malignancy, and chemoresistance to a number of anti-cancer drugs. However, the mechanism of EMT induction in the process of acquiring anti-cancer drug resistance remains unclear. To address this issue, we obtained a number of cisplatin-resistant clones from LoVo cells and found that almost all of them lost cell-cell contacts. In these clones, the epithelial marker E-cadherin was downregulated, whereas the mesenchymal marker N-cadherin was upregulated. Moreover, the expression of EMT-related transcription factors, including Slug, was elevated. On the other hand, the upregulation of other mesenchymal marker Vimentin… More >

  • Open Access

    ARTICLE

    Biochanin A, as the Lrg1/TGF-β/Smad2 pathway blockade, attenuates blood-brain barrier damage after cerebral ischemia-reperfusion by modulating leukocyte migration patterns

    LONGSHENG FU1, JINFANG HU1, FENG SHAO2, YAOQI WU1, WEI BAI3, MINGJIN JIANG3, HAO CHEN4, LIHUA CHEN2, YANNI LV1,*

    BIOCELL, Vol.47, No.8, pp. 1869-1883, 2023, DOI:10.32604/biocell.2023.028602

    Abstract Background: Biochanin A is an excellent dietary isoflavone that has the concomitant function of both medicine and foodstuff. The attenuation function of biochanin A on blood-brain barrier (BBB) damage induced by cerebral ischemia-reperfusion remains unclear. Methods: C57BL/6 mice were subjected to 1 h middle cerebral artery occlusion (MCAO) followed by 24 h reperfusion. The infarct volume of the brain was stained by TTC, while leakage of the brain was quantitatively stained by Evans blue, and the neurologic deficit score was measured. Microglial-induced morphologic changes were observed via immunofluorescence staining, and rolling and adhering leukocytes in venules were observed via two-photon… More >

  • Open Access

    ARTICLE

    Flexible Biofoams Based on Furanics and Fatty Acids Esterified Tannin

    Elham Azadeh1, Ummi Hani Abdullah2,3, Christine Gerardin1,*, Antonio Pizzi1,*, Philippe Gerardin1, Cesar Segovia4

    Journal of Renewable Materials, Vol.11, No.10, pp. 3625-3645, 2023, DOI:10.32604/jrm.2023.030373

    Abstract Water repellant, flexible biofoams using tannin esterified with various fatty acid chains, namely lauric, palmitic and oleic acids, by reaction with lauryl chloride, palmitoyl chloride, and oleyl chloride were developed and their characteristics compared with the equivalently esterified rigid biofoams. Glycerol, while initially added to control the reaction temperature, was used as a plasticizer yielding flexible biofoams presenting the same water repellant character that the equivalent rigid foams. Acetaldehyde was used as the cross-linking agent instead of formaldehyde, as it showed a better performance with the esterified tannin. The compression results showed a significant decrease of the Modulus of Elasticity… More >

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