EGOR V. BATOROV^1,2,*, ALISA D. INESHINA², TATIANA A. ARISTOVA³, VERA V. DENISOVA³, SVETLANA A. SIZIKOVA³, DARIA S. BATOROVA³, GALINA Y. USHAKOVA³, EKATERINA Y. SHEVELA¹, ELENA R. CHERNYKH¹

Oncology Research, Vol.32, No.10, pp. 1575-1587, 2024, DOI:10.32604/or.2024.047893

Abstract Background: Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma (MM) progression. Simultaneously, previous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with common γ-chain family cytokines in vitro and during homeostatic proliferation. The aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets up-regulating PD-1 and TIM-3 checkpoint molecules. Methods: The expression of CD25, CD122, CD127 common γ-chain cytokine receptors, phosphorylated signal transducer and activator of transcription-5 (pSTAT5) and eomesodermin (EOMES) was comparatively assessed with flow… More >

Nada Charfi^1,3,*, Nour Regaieg^1,3, Ines Ayadi^2,3, Najeh Smaoui^1,3, Rim Feki^1,3, Imen Gassara^1,3, Sana Omri^1,3, Lobna Zouari^1,3, Jihène Ben Thabet^1,3, Manel Maâlej Bouali^1,3, Afef Khanfir^2,3, Mohamed Maâlej^1,3

Psycho-Oncologie, Vol.18, No.3, pp. 241-248, 2024, DOI:10.32604/po.2024.049038

Abstract Le diagnostic et la prise en charge du cancer du sein (CS) affectent d’une manière complexe la vie sexuelle des femmes et touchent au symbole de la féminité, qui est très important dans la constitution de l’image du corps. Nos objectifs ont été d’évaluer le fonctionnement sexuel et l’image du corps des patientes en rémission d’un CS localisé, de déterminer les liens entre ces deux paramètres et d’étudier leur rapport avec les modalités thérapeutiques du CS. Nous avons mené une étude transversale, descriptive et analytique au sein des services d’oncologie médicale et de radiothérapie du… More >

Tajim Md. Niamat Ullah Akhund^1,2,*, Waleed M. Al-Nuwaiser³

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 3485-3506, 2024, DOI:10.32604/cmc.2024.054222

Abstract This study explores the impact of hyperparameter optimization on machine learning models for predicting cardiovascular disease using data from an IoST (Internet of Sensing Things) device. Ten distinct machine learning approaches were implemented and systematically evaluated before and after hyperparameter tuning. Significant improvements were observed across various models, with SVM and Neural Networks consistently showing enhanced performance metrics such as F1-Score, recall, and precision. The study underscores the critical role of tailored hyperparameter tuning in optimizing these models, revealing diverse outcomes among algorithms. Decision Trees and Random Forests exhibited stable performance throughout the evaluation. While More >

Irum Ilays¹, Yaser Hafeez^1,*, Nabil Almashfi², Sadia Ali¹, Mamoona Humayun^3,*, Muhammad Aqib¹, Ghadah Alwakid⁴

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 3761-3784, 2024, DOI:10.32604/cmc.2024.053830

Abstract Software testing is a critical phase due to misconceptions about ambiguities in the requirements during specification, which affect the testing process. Therefore, it is difficult to identify all faults in software. As requirement changes continuously, it increases the irrelevancy and redundancy during testing. Due to these challenges; fault detection capability decreases and there arises a need to improve the testing process, which is based on changes in requirements specification. In this research, we have developed a model to resolve testing challenges through requirement prioritization and prediction in an agile-based environment. The research objective is to… More >

Selwin Maria Sekar¹, Rajini Nagarajan^1,*, Ponsuriyaprakash Selvakumar², Ismail Sikiru Oluwarotimi³, Kumar Krishnan⁴, Faruq Mohammad⁵, Mohammed Rafi Shaik⁵, Nadir Ayrilmis^6,*

Journal of Renewable Materials, Vol.12, No.8, pp. 1455-1474, 2024, DOI:10.32604/jrm.2024.052952

Abstract An innovative microcrystalline cellulose (MCC) natural fibre powder-reinforced PLA biocomposite was investigated using the hand lay-up technique. The polymer matrix composite (PMC) samples were prepared by varying the weight percentages (wt.%) of both PLA matrix and MCC reinforcement: pure PLA/100:0, 90:10, 80:20, 70:30, 60:40 and 50:50 wt.%, respectively. From the results obtained, MCC powder, with its impressive aspect ratio, proved to be an ideal reinforcement for the PLA, exhibiting exceptional mechanical properties. It was evident that the 80:20 wt.% biocomposite sample exhibited the maximum improvement in the tensile, flexural, notched impact, compressive strength and hardness… More >

HAOTONG SUN^1,2,#, HEYING WANG^1,2,#, YANJIE HAO^1,2, XIN LI^1,2, JUN LING^1,2, HUAN WANG^1,2, FEIMIAO WANG^1,2, FANG XU^1,2,*

BIOCELL, Vol.48, No.9, pp. 1311-1322, 2024, DOI:10.32604/biocell.2024.052451

Abstract Background: Colorectal cancer is a major global health concern, exacerbated by tumor necrosis factor-alpha(TNF-α) and its role in inflammation, with the effects of Mitotic Arrest Deficient 2 Like 2 (MAD2L2) in this context still unclear. Methods: The colorectal carcinoma cell lines HCT116 and SW620 were exposed to TNF-α for a period of 24 h to instigate an inflammatory response. Subsequent assessments were conducted to measure the expression of inflammatory cytokines, the activity within the p38 mitogen-activated protein kinase (p38 MAPK) and Phosphoinositide 3-Kinase/AKT Serine/Threonine Kinase pathway (PI3K/AKT) signaling cascades. Transcriptome sequencing and subsequent integrative analysis… More >

WENJUAN ZHU¹, ZHENGZHENG JU², FAN CUI^2,*

BIOCELL, Vol.48, No.9, pp. 1379-1388, 2024, DOI:10.32604/biocell.2024.052205

Abstract Objective: Diabetic nephropathy (DN) is a deleterious microangiopathy of diabetes, constituting a critical determinant of fatality in diabetic patients. This work is purposed to disclose the effects and modulatory mechanism of BTG anti-proliferation factor 2 (BTG2) during the pathological process of DN. Methods: BTG2 expression in kidney tissues of diabetic mice and high glucose (HG)-exposed human proximal tubular cell line HK-2 was assessed with Western blot and RT-qPCR. The diabetic mice model was constructed by streptozotocin injection and confirmed by the blood glucose level beyond 16.7 mmol/L. Hematoxylin and eosin (H&E) staining and measurement of… More >

WEIGANG REN^1,#, JING LI^2,#, RUIJIANG ZENG^3,4, LIANG ZHU^3,4,*

BIOCELL, Vol.48, No.9, pp. 1323-1330, 2024, DOI:10.32604/biocell.2024.051747

Abstract Background: Clear cell renal cell carcinoma (ccRCC) stands as the most prevalent form of kidney cancer, accounting for a significant proportion of malignancies affecting the kidneys. ccRCC is well known as a type of tumour with immunogenicity. Immune checkpoint inhibitors (ICIs) aim to enhance the anticancer immune response in ccRCC by blocking programmed cell death 1 ligand 1/programmed death 1 (PD-L1/PD-1) pathways. In a previous study, we showed that RING finger protein 26 (RNF26) degrades chromobox 7 (CBX7) to activate the tumor necrosis factor (TNF) in ccRCC. Methods: We analyzed The Cancer Genome Atlas (TCGA)… More > Graphic Abstract

JING WANG^1,#, JUNFENG XU^2,#, YINGRAN YANG¹, YOUZHENG QIU¹, SHANSHAN ZHANG³, NING WANG^1,3,*

BIOCELL, Vol.48, No.9, pp. 1343-1353, 2024, DOI:10.32604/biocell.2024.051673

Abstract Objective: This study aimed to elucidate the influence of IFN-gamma (IFN-γ) in neuroblastoma (NB) cells and reveal its potential underlying molecular mechanism. Methods: The Cell Counting Kit-8, Transwell apparatus, and flow cytometry were employed to assess cellular viability, migratory capacity, invasive potential, and apoptotic rates, respectively. RNA-seq combined with bioinformatics analysis revealed differentially expressed genes (DEGs) and their possible biological functions. Protein levels were determined by western blot analysis. Results: IFN-γ treatment resulted in diminished cell viability, mitigated migratory and invasive capabilities, and augmented apoptotic activity in the SK-N-BE (2) cell line, whereas it exhibited the… More >

LEI SHI^1,#, JIANSHI YIN^2,#, YU CHEN¹, JIANGANG SHI¹, JINHAO MIAO^1,*

BIOCELL, Vol.48, No.9, pp. 1389-1400, 2024, DOI:10.32604/biocell.2024.049562

Abstract Background: Ossification of the posterior longitudinal ligament (OPLL) is a prevalent condition in orthopedics. While death-associated protein kinase 2 (DAPK2) is known to play roles in cellular apoptosis and autophagy, its specific contributions to the advancement of OPLL are not well understood. Methods: Ligament fibroblasts were harvested from patients diagnosed with OPLL. Techniques such as real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) and Western blot analysis were employed to assess DAPK2 levels in both ligament tissues and cultured fibroblasts. The extent of osteogenic differentiation in these cells was evaluated using an alizarin red S (ARS) staining. Additionally,… More >