Yushan Ye¹, Tao Gao¹, Liankun Wang², Junjie Ma², Yingchun Cai², Heng Liu^2,*, Xiaoge Liu²

Structural Durability & Health Monitoring, Vol.19, No.1, pp. 145-166, 2025, DOI:10.32604/sdhm.2024.053756 - 15 November 2024

Abstract To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams, destructive tests were conducted on full-scale pre-stressed concrete beams. Based on the measurement and analysis of beam deflection, strain, and crack development under various loading levels during the research tests, combined with the verification coefficient indicators specified in the codes, the verification coefficients of bridges at different stages of damage can be examined. The results indicate that the T-beams experience complete, incomplete linear, and… More >

Aruna M. Pugalenthi^*, Khaoula Khlie

Journal of Renewable Materials, Vol.12, No.11, pp. 1879-1893, 2024, DOI:10.32604/jrm.2024.055747 - 22 November 2024

Abstract With growing environmental concerns and the depletion of oil reserves, the need to replace synthetic fibres with sustainable alternatives in composite materials has become increasingly urgent. This study investigates the potential of Leptadenia pyrotechnica fibre as a sustainable reinforcement material in hybrid composites alongside E-glass fibres. The primary objectives are to assess these hybrid composites’ mechanical properties, structural integrity, and performance. To achieve this, Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR) were employed to analyze the microstructure and chemical composition of the composites. At the same time, mechanical testing focused on properties such… More >

Bing Shi^1,*, Jianhua Zhao¹, Bin Ma¹, Juan Huan², Yueping Sun³

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2437-2456, 2024, DOI:10.32604/cmc.2024.056377 - 18 November 2024

Abstract Real-time detection of unhealthy fish remains a significant challenge in intensive recirculating aquaculture. Early recognition of unhealthy fish and the implementation of appropriate treatment measures are crucial for preventing the spread of diseases and minimizing economic losses. To address this issue, an improved algorithm based on the You Only Look Once v5s (YOLOv5s) lightweight model has been proposed. This enhanced model incorporates a faster lightweight structure and a new Convolutional Block Attention Module (CBAM) to achieve high recognition accuracy. Furthermore, the model introduces the α-SIoU loss function, which combines the α-Intersection over Union (α-IoU) and… More >

Chen Chen, Kai Qiao, Jie Yang, Jian Chen, Bin Yan^*

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2629-2642, 2024, DOI:10.32604/cmc.2024.056038 - 18 November 2024

Abstract Computed Tomography (CT) is a commonly used technology in Printed Circuit Boards (PCB) non-destructive testing, and element segmentation of CT images is a key subsequent step. With the development of deep learning, researchers began to exploit the “pre-training and fine-tuning” training process for multi-element segmentation, reducing the time spent on manual annotation. However, the existing element segmentation model only focuses on the overall accuracy at the pixel level, ignoring whether the element connectivity relationship can be correctly identified. To this end, this paper proposes a PCB CT image element segmentation model optimizing the semantic perception… More >

WEITAO ZHENG¹, DONG JIANG², SONGEN CHEN¹, MEILING WU¹, BAOQI YAN², JIAHUI ZHAI², YUNQIANG SHI², BIN XIE¹, XINGWANG XIE², KANGHONG HU^1,*, WENXUE MA^3,*

Oncology Research, Vol.32, No.12, pp. 1837-1850, 2024, DOI:10.32604/or.2024.056565 - 13 November 2024

Abstract Objectives: The Kirsten rat sarcoma virus (KRAS) G12D oncogenic mutation poses a significant challenge in treating solid tumors due to the lack of specific and effective therapeutic interventions. This study aims to explore innovative approaches in T cell receptor (TCR) engineering and characterization to target the KRAS G12D_7-16 mutation, providing potential strategies for overcoming this therapeutic challenge. Methods: In this innovative study, we engineered and characterized two T cell receptors (TCRs), KDA11-01 and KDA11-02 with high affinity for the KRAS G12D_7-16 mutation. These TCRs were isolated from tumor-infiltrating lymphocytes (TILs) derived from tumor tissues of patients More >

CHAOQUN WANG¹, TING ZHANG², CHAOHE ZHANG^3,*

Oncology Research, Vol.32, No.12, pp. 1867-1879, 2024, DOI:10.32604/or.2024.044547 - 13 November 2024

Abstract Background: Drug resistance is the main factor contributing to cancer recurrence and poor prognosis. Exploration of drug resistance-related mechanisms and effective therapeutic targets are the aim of molecular targeted therapy. In our study, the role of long non-coding RNA (lncRNA) AFAP1-AS1 in gemcitabine resistance and related mechanisms were explored in cervical cancer cells. Methods: Gemcitabine-resistant cervical cancer cell lines HT-3-Gem and SW756-Gem were constructed using the gemcitabine concentration gradient method. The overall survival rates and recurrence-free survival rates were evaluated by Kaplan-Meier analysis. The interaction was verified through a Dual-luciferase reporter gene assay and a… More > Graphic Abstract

Priyanka¹, Damodarakurup Sajeev², Shaik Ahmed³, Shankar Pidishety³, Ram Soorat^3,*

Journal of Quantum Computing, Vol.6, pp. 53-66, 2024, DOI:10.32604/jqc.2024.054000 - 14 November 2024

Abstract The present study delves into the application of investigating quantum state behaviour, particularly focusing on coherent and superposition states. These states, characterized by their remarkable stability and precision, have found extensive utility in various domains of quantum mechanics and quantum information processing. Coherent states are valuable for manipulating quantum systems with accuracy. Superposition states allow quantum systems to exist in numerous configurations at the same time, which paves the way for quantum computing’s capacity for parallel processing. The research accentuates the crucial role of quantum error correction (QEC) in ensuring the stability and reliability of… More >

Guizhou Liu^1,2, Chunze Yan^1,2,*, Yusheng Shi^1,2

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.013340

Abstract High-volume-fraction SiC/Al (HVF-SiC/Al) have a wide range of applications in aerospace, optics, automotive and electronic packaging. However, because the hardness, brittleness and wear resistance increase with the increase in the volume fraction, it is difficult for traditional methods such as machining, to process HVF-SiC/Al composites to complex components. Therefore, in this paper, a novel method of the hybrid additive manufacturing is proposed to fabricate HVF-SiC/Al parts with complex structures. The effect of polymer infiltration and pyrolysis (PIP) on microstructure and properties of HVF-SiC/Al composites is investigated. The results show that the mechanical properties of the… More >

Jiawei Fu^1,2,*, Yahui Cai¹, Bowen Zhang¹, Zengxiang Qi¹, Lehua Qi¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.013007

Abstract The accurate characterization of the anisotropic thermal-mechanical constitutive properties of structural sheet metals at elevated temperatures and under nonuniform stress/strain states is crucial for the precise hot plastic forming and structural behavior evaluation of an engineering sheet part. Traditional thermal-mechanical testing methods rely on the assumption of states homogeneity, leading to a large number of tests required for the characterization of material anisotropy and nonlinearity at various high temperatures. In this work, a highly efficient identification method is proposed that allows the simultaneous characterization of the anisotropic yielding, strain hardening and elasto-plasticity thermal softening material More >

TIANYUN HAN^#, ZHONG LI^#, LUONING ZHANG, LINSHEN XIE^*

BIOCELL, Vol.48, No.11, pp. 1625-1638, 2024, DOI:10.32604/biocell.2024.055029 - 07 November 2024

Abstract Objective: The study aimed to explore the protective mechanism of Ganoderic acid A (GAA) in renal fibrosis and to verify that GAA can ameliorate renal fibrosis by regulating the Niemann-pick C1-like 1 (NPC1L1) gene. Methods: Transforming growth factor beta1 (TGF-β1) was used to treat Human Kidney-2 (HK-2) cells to establish a renal fibrosis model. The differentially expressed genes in the control (CTRL) group, TGF-β1 group, and TGF-β1 + GAA group were screened via transcriptome sequencing technology and verified by qPCR and Western blot experiments. The NPC1L1 gene overexpression plasmid was constructed. The expression levels of N-cad, E-cad,… More >