LISANNE K.A. NEIJENHUIS^1,2,3,#, LEUTA L. NAUMANN^4,#, SONIA A.M. FERKEL¹, SAMUEL J.S. RUBIN¹, STEPHAN ROGALLA^1,*

Oncology Research, Vol.32, No.7, pp. 1163-1172, 2024, DOI:10.32604/or.2024.050907 - 20 June 2024

Abstract Background: Osteosarcoma is the most common malignant primary bone tumor. The prognosis for patients with disseminated disease remains very poor despite recent advancements in chemotherapy. Moreover, current treatment regimens bear a significant risk of serious side effects. Thus, there is an unmet clinical need for effective therapies with improved safety profiles. Taurolidine is an antibacterial agent that has been shown to induce cell death in different types of cancer cell lines. Methods: In this study, we examined both the antineoplastic and antiangiogenic effects of taurolidine in animal models of osteosarcoma. K7M2 murine osteosarcoma cells were… More >

Ketut Putu Yasa^1,2,*, Nyoman Satria Sadu Bhaskara², Putu Febry Krisna Pertiwi²

Congenital Heart Disease, Vol.19, No.2, pp. 139-156, 2024, DOI:10.32604/chd.2024.050348 - 16 May 2024

Abstract Objective: Patients with ductal-dependent pulmonary circulation require alternative blood flow to provide and maintain adequate oxygenation. Modified Blalock-Taussig Shunt (MBTS) has been the standard for providing such a result. Currently, less invasive methods such as Arterial Duct (AD) stenting have been performed as alternatives. This study aims to compare the outcome of AD stenting and MBTS. Method: Systematic research was performed in online databases using the PRISMA protocol. The outcomes measured were 30-day mortality, complication, unplanned intervention, oxygen saturation, duration of hospital, and ICU length of stay. Any comparative study provided with full text is… More >

Jutarat Tanasansuttiporn¹, Maliwan Oofuvong^1,*, Wirat Wasinwong¹, Voravit Chittithavorn², Pongsanae Duangpakdee², Jirayut Jarutach³, Qistina Yunuswangsa¹

Congenital Heart Disease, Vol.17, No.3, pp. 245-267, 2022, DOI:10.32604/chd.2022.021778 - 03 May 2022

Abstract Background: Studies on predictors of health-related quality of life (HRQOL) in pediatric patients with cyanotic heart disease who are waiting for the next stage and those who have undergone total repair are scarce. Therefore, we aimed to identify such predictors in children who received the modified Blalock–Taussig shunt (MBTS) and those who underwent total repair. Methods: In this historical cohort and concurrent follow-up study, data of children who underwent MBTS at the age of 0–3 years between January 2005 and December 2016 at a super-tertiary care hospital in Southern Thailand were obtained. Children who were alive… More > Graphic Abstract

MOHAMED AGHYAD AL KABBANI^1,2, GILBERT WUNDERLICH^3,4, CHRISTOPH KöHLER⁵, HANS ZEMPEL^1,2,*

BIOCELL, Vol.46, No.4, pp. 847-853, 2022, DOI:10.32604/biocell.2022.018144 - 15 December 2021

Abstract Tauopathies comprise a spectrum of genetic and sporadic neurodegenerative diseases mainly characterized by the presence of hyperphosphorylated TAU protein aggregations in neurons or glia. Gene therapy, in particular adeno-associated virus (AAV)-based, is an effective medical approach for difficult-to-treat genetic diseases for which there are no convincing traditional therapies, such as tauopathies. Employing AAV-based gene therapy to treat, in particular, genetic tauopathies has many potential therapeutic benefits, but also drawbacks which need to be addressed in order to successfully and efficiently adapt this still unconventional therapy for the various types of tauopathies. In this Viewpoint, we More >

Sibao Wang, Silin Pan^*, Gang Luo, Zhixian Ji, Na Liu

Congenital Heart Disease, Vol.17, No.1, pp. 45-60, 2022, DOI:10.32604/CHD.2022.016332 - 26 October 2021

Abstract The aim of this study was to perform a systematic review and meta-analysis to evaluate the safety and efficacy of ductus arteriosus stent (DAS) compared with surgical systemic-pulmonary artery shunt (SPS) in patients with ductal-dependent pulmonary blood flow. A literature search was conducted in PubMed, Embase, and the Cochrane Library databases from their inception to December 2020. Two reviewers independently screened the articles, evaluated the quality of the articles, and collected the data. Meta-analyses were conducted using fixed and random effects models. We used the I-square (I² ) test to examine heterogeneity and the funnel plot… More >

Hosam F. El-Sofany^1,2,*, Samir A. El-Seoud³

Computer Systems Science and Engineering, Vol.40, No.1, pp. 389-404, 2022, DOI:10.32604/csse.2022.018619 - 26 August 2021

Abstract Ubiquitous computing supports U-learning to develop and implement a new educational environment that provides effective and interactive learning to students wherever they are. This study aims to present a qualitative evaluation for using U-learning instead of traditional education to avoid the spread of the Coronavirus pandemic. The authors introduce a UTAUT (Unified Theory of Acceptance and Use of Technology) model to assess the capability of the given factors that are expected to affect the learners’ intention and behavior for accepting the U-learning technology for full E-learning. The research study shows a promising impact on the… More >

NARAYANAN NAMPOOTHIRI V. P.¹, VIGNESH SUNDARARAJAN¹, PALLAVI DAN¹, G. DEVANAND VENKATASUBBU^2,*, SAHABUDEEN SHEIK MOHIDEEN^1,*

BIOCELL, Vol.45, No.5, pp. 1251-1262, 2021, DOI:10.32604/biocell.2021.015090 - 12 July 2021

Abstract Alzheimer’s disease (AD) is one of the most common forms of dementia. Cognitive dysfunction and memory loss are the two main clinical symptoms of AD. Drosophila melanogaster models of AD, which are based on overexpression of human amyloid β (Aβ) or human tau (hTau) protein, have been used to study the mechanism underlying AD and to screen potential therapeutic compounds. Drugs that are currently available for AD provide only symptomatic relief. Huge unmet medical needs exists to slow, stop, or reverse the progression of AD. Thymoquinone (TQ) is an active ingredient isolated from Nigella sativa (NS) and… More >

Siraphop Thapmongkol^1,*, Jarun Sayasathid¹, Jessada Methrujpanont², Kanthachat Thatsakorn¹, Worawan Jittham³, Suwanna Puitm⁴, Methiniwiran Thapmongkol⁵, Jule Namchaisiri⁶

Congenital Heart Disease, Vol.16, No.5, pp. 433-441, 2021, DOI:10.32604/CHD.2021.015770 - 03 June 2021

Abstract Background: The surgical outcomes of tetralogy of Fallot (TOF) have evolved dramatically and have resulted in lower mortality rate. Currently, the many cardiac centers have a trend to early single-stage complete repair more than a staged repair. However, the patients who have an early primary repair were required transannular patch augmentation of a pulmonary valve frequently. This effect has been developed a chronic pulmonary insufficiency may lead to right ventricular dilation, dysfunction. In this era, the aim of treatment of TOF is attempted to preserve pulmonary valve annulus for prevent right ventricular dysfunction in the future.… More >

Pierre-Guillaume Poureau^1,2,*, Jean-Philippe Metges²

Oncologie, Vol.23, No.1, pp. 47-59, 2021, DOI:10.32604/Oncologie.2021.15525 - 30 March 2021

Abstract L’immunothérapie des cancers digestifs est en plein essor et pour la première fois un inhibiteur de point de contrôle immunitaire a obtenu une autorisation de mise sur le marché pour le traitement d’un cancer digestif. Afin d’appréhender au mieux le mécanisme d’action de ces traitements, leurs effets secondaires et l’échappement à ces traitement, il est nécessaire de connaître les fondamentaux de l’immunologie des cancers. Le système immunitaire inné et adaptatif permet l’élimination des cellules cancéreuses par cytotoxicité directe non spécifique (cellules Natural Killer), par le développement d’une réponse adaptative à médiation cellulaire (cellules dendritiques devenant… More >

Malik Khlaif Gharaibeh¹, Natheer Khlaif Gharaibeh^2,*, Mohammad Ayoub Khan³, Waleed Abdel karim Abu-ain⁴, Musab Kasim Alqudah²

Computer Systems Science and Engineering, Vol.37, No.2, pp. 187-202, 2021, DOI:10.32604/csse.2021.014902 - 01 March 2021

Abstract This article examines the main variables that influence the intention to use Augmented Reality (AR) applications in the tourism sector in Jordan. The study model has been constructed based on the unified theory of acceptance and the use of technology2 (UTAUT2), by incorporating a new construct (aesthetics) to explore the usage intention of Mobile Augmented Reality in Tourism (MART). A questionnaire was used and distributed to a sample of 450 participants. Data were analyzed using the Smart PLS version 3.0. for testing 12 hypotheses. 29 measurement items were carefully reviewed based on previous studies that… More >