Hung-Tsung Lee^*, Cheng-Hsieh Huang^†, Wuan-Chun Chen^†, Chi-Shan Tsai^†, Yu-Lin Chao^†, Szu-Han Liu^†, Jun-Hong Chen^†, Yi-Ying Wu^‡, Yi-Ju Lee^†§

Oncology Research, Vol.26, No.8, pp. 1175-1182, 2018, DOI:10.3727/096504018X15149761920868

Abstract Lung cancer is the leading cause of cancer deaths worldwide. Given that the major threat of cancer is metastasis, delineation of the molecular mechanism underlying it would help devise therapeutic strategies. Transglutaminase 2 (TG2), belonging to the transglutaminase superfamily, is a versatile protein with enzymatic and nonenzymatic functions. It mainly localizes inside the cell, but also appears extracellularly. Recent findings have demonstrated the involvement of TG2 in cancer development. Here we examine the role of TG2 in metastasis of lung cancer using a lung cancer cell line CL1-0, which exhibits low invasiveness, and its invasive… More >

ZHILI ZHUO^#, DONGNI ZHANG^#, WENPING LU^*, XIAOQING WU, YONGJIA CUI, WEIXUAN ZHANG, MENGFAN ZHANG

Oncology Research, Vol.32, No.6, pp. 1093-1107, 2024, DOI:10.32604/or.2024.047257

Abstract Breast cancer is the leading cause of cancer-related deaths in women worldwide, with Hormone Receptor (HR)+ being the predominant subtype. Tamoxifen (TAM) serves as the primary treatment for HR+ breast cancer. However, drug resistance often leads to recurrence, underscoring the need to develop new therapies to enhance patient quality of life and reduce recurrence rates. Artemisinin (ART) has demonstrated efficacy in inhibiting the growth of drug-resistant cells, positioning art as a viable option for counteracting endocrine resistance. This study explored the interaction between artemisinin and tamoxifen through a combined approach of bioinformatics analysis and experimental… More > Graphic Abstract

Manal Abdullah Alohali¹, Muna Elsadig¹, Fahd N. Al-Wesabi², Mesfer Al Duhayyim³, Anwer Mustafa Hilal^4,*, Abdelwahed Motwakel⁴

Computer Systems Science and Engineering, Vol.48, No.3, pp. 759-771, 2024, DOI:10.32604/csse.2023.037305

Abstract Owing to the rapid increase in the interchange of text information through internet networks, the reliability and security of digital content are becoming a major research problem. Tampering detection, Content authentication, and integrity verification of digital content interchanged through the Internet were utilized to solve a major concern in information and communication technologies. The authors’ difficulties were tampering detection, authentication, and integrity verification of the digital contents. This study develops an Automated Data Mining based Digital Text Document Watermarking for Tampering Attack Detection (ADMDTW-TAD) via the Internet. The DM concept is exploited in the presented… More >

Qi Zhang^1,2,4,5, Zhixin Chen³, Yang Wu^4,*, Guoqi Xiang², Guang Wen¹, Xuegang Zhang², Yongchun Xie², Guangchun Yang²

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 593-619, 2024, DOI:10.32604/cmes.2023.046319

Abstract Although there is currently no unified standard theoretical formula for calculating the contact stress of cylindrical gears with a circular arc tooth trace (referred to as CATT gear), a mathematical model for determining the contact stress of CATT gear is essential for studying how parameters affect its contact stress and building the contact stress limit state equation for contact stress reliability analysis. In this study, a mathematical relationship between design parameters and contact stress is formulated using the Kriging Metamodel. To enhance the model’s accuracy, we propose a new hybrid algorithm that merges the genetic… More >

LAVANYA, R¹, NATCHIMUTHU, N^2,*

Journal of Polymer Materials, Vol.38, No.1-2, pp. 89-100, 2021, DOI:10.32381/JPM.2021.38.1-2.8

Abstract Rubber composites of nitrile (NBR) and Ethylene-Propylene-Diene (EPDM) containing unmodified and modified microcrystalline cellulose(MCC) are evaluated for their processing behaviour. The used modified MCC (T-MCC) was treated by N,N-dimethylacetamide/lithium chloride (DMAc/ LiCl).ATR-FTIR spectra of NBR-MCC composites have indicated N-H stretching and bending vibrations and confirmed interactions between nitrile rubber and MCC. AFM studies have indicated that the average roughness of NBR-T-MCC was significantly reduced when compared to that of NBR-untreated MCC. Important processing parameters such as scorch time and cure time are found to decrease significantly for both NBR and EPDM composites withT-MCC. Mechanical properties More >

NIKHIL R. MENE¹, SARITA KALLA^1,*, Z.V.P. MURTHY^1,*

Journal of Polymer Materials, Vol.39, No.3-4, pp. 307-323, 2022, DOI:10.32381/JPM.2022.39.3-4.9

Abstract Membrane distillation-crystallization (MDC) is presented as a novel technique in the treatment of waste concentrated water which produces valuable crystals along with pure water. In the present study, multi-walled carbon nanotubes (MWCNT)/polyvinylidene fluoride (PVDF) flat sheet membranes were prepared via the wet phase inversion method and applied in MDC for the treatment of pharmaceutical waste. The pure and modified membrane surface properties are characterized with the help of SEM, FTIR, and contact angle measurement. The present work reported the effect of MWCNT content and feed temperature on the MDCperformance and measured pure water flux and More >

Honghui Sun^1,2,#, Ruichao Liu^1,2,#, Yueting Qi¹, Hongsheng Gao¹, Xueting Wang¹, Ning Jiang^1,2, Xiaotong Guo^1,2, Hongxia Zhang¹, Chunyan Yu^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 533-549, 2024, DOI:10.32604/phyton.2024.049417

Abstract Grapes, one of the oldest tree species globally, are rich in vitamins. However, environmental conditions such as low temperature and soil salinization significantly affect grape yield and quality. The glutamate receptor (GLR) family, comprising highly conserved ligand-gated ion channels, regulates plant growth and development in response to stress. In this study, 11 members of the VvGLR gene family in grapes were identified using whole-genome sequence analysis. Bioinformatic methods were employed to analyze the basic physical and chemical properties, phylogenetic trees, conserved domains, motifs, expression patterns, and evolutionary relationships. Phylogenetic and collinear analyses revealed that the VvGLRs… More >

ARCHNA RANI

Journal of Polymer Materials, Vol.39, No.1-2, pp. 17-35, 2022, DOI:10.32381/JPM.2022.39.1-2.2

Abstract Accumulation of Microplastics (MPs) in diverse ecosystems is a growing global problem of our time. These are entering into the environment directly (micro-sized plastics manufactured purposefully) and by degradation of plastic products. Due to a diverse range of polymers and additives used to manufacture plastic products, the MPs of different chemical compositions are abundant in the environment. A detailed literature survey revealed that MPs -environment interaction is largely governed by these chemicals and other intrinsic properties of MPs viz. shape, size, density, surface charge, etc. The current investigation primarily aims to review different chemical and More >

Fei Wang, Qinpeng Meng, Jinchi Zhao, Xin Wang, Yuhong Liu, Qianru Zhang^*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.4, pp. 829-846, 2024, DOI:10.32604/fdmp.2023.026917

Abstract Buildings with large open spaces in which chemicals are handled are often exposed to the risk of explosions. Computational fluid dynamics is a useful and convenient way to investigate contaminant dispersion in such large spaces. The turbulent Schmidt number (Sc_t) concept has typically been used in this regard, and most studies have adopted a default value. We studied the concentration distribution for sulfur hexafluoride (SF₆) assuming different emission rates and considering the effect of Sc_t. Then we examined the same problem for a light gas by assuming hydrogen gas (H₂) as the contaminant. When SF₆ was considered as More >

Bing Liu¹, Zhe Zhang¹, Shengrong Hu², Song Sun^3,*, Dapeng Liu⁴, Zhenyu Qiu⁵

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 4049-4069, 2024, DOI:10.32604/cmc.2024.048099

Abstract Internet of Things (IoT) is vulnerable to data-tampering (DT) attacks. Due to resource limitations, many anomaly detection systems (ADSs) for IoT have high false positive rates when detecting DT attacks. This leads to the misreporting of normal data, which will impact the normal operation of IoT. To mitigate the impact caused by the high false positive rate of ADS, this paper proposes an ADS management scheme for clustered IoT. First, we model the data transmission and anomaly detection in clustered IoT. Then, the operation strategy of the clustered IoT is formulated as the running probabilities… More >