Liyun Shen, Xingjun Du, Hongyan Ma, Shunxi Mei
Oncology Research, Vol.25, No.9, pp. 1643-1651, 2017, DOI:10.3727/096504017X14908284471361
Abstract miRNAs have been involved in various types of cancer, including T-cell leukemia. In this study, the role of
miR-1193 in the proliferation and invasion of T-cell leukemia cells was explored. First, we found that miR-1193
was sharply downregulated in T-cell leukemia cells when compared with normal T cells. miR-1193 markedly
decreased the proliferation and invasion in Jurkat human T-cell leukemia cells. Transmembrane 9 superfamily 3 (TM9SF3) was then predicted to be a potential target gene of miR-1193, the levels of which displayed a
strongly negative correlation with miR-1193 levels in T-cell leukemia patients. We confirmed More >
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