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Search Results (103)
  • Open Access

    REVIEW

    Mental Health and Well-Being of Doctoral Students: A Systematic Review

    Yuxin Guo1,2, Xinqiao Liu3,*

    International Journal of Mental Health Promotion, Vol.28, No.1, 2026, DOI:10.32604/ijmhp.2025.074063 - 28 January 2026

    Abstract Background: Mental health concerns among doctoral students have become increasingly prominent, with consistently low levels of well-being making this issue a critical focus in higher education research. This study aims to synthesize existing evidence on the mental health and well-being of doctoral students and to identify key factors and intervention strategies reported in the literature. Methods: A systematic review was conducted to examine the determinants and interventions related to doctoral students’ mental health and well-being. Relevant studies were comprehensively searched in Web of Science, PubMed, Scopus, and EBSCO, with the final search conducted on September 19,… More >

  • Open Access

    REVIEW

    The Transparency Revolution in Geohazard Science: A Systematic Review and Research Roadmap for Explainable Artificial Intelligence

    Moein Tosan1,*, Vahid Nourani2,3, Ozgur Kisi4,5,6, Yongqiang Zhang7, Sameh A. Kantoush8, Mekonnen Gebremichael9, Ruhollah Taghizadeh-Mehrjardi10, Jinhui Jeanne Huang11

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.074768 - 29 January 2026

    Abstract The integration of machine learning (ML) into geohazard assessment has successfully instigated a paradigm shift, leading to the production of models that possess a level of predictive accuracy previously considered unattainable. However, the black-box nature of these systems presents a significant barrier, hindering their operational adoption, regulatory approval, and full scientific validation. This paper provides a systematic review and synthesis of the emerging field of explainable artificial intelligence (XAI) as applied to geohazard science (GeoXAI), a domain that aims to resolve the long-standing trade-off between model performance and interpretability. A rigorous synthesis of 87 foundational… More >

  • Open Access

    REVIEW

    A Systematic Review of Frameworks for the Detection and Prevention of Card-Not-Present (CNP) Fraud

    Kwabena Owusu-Mensah*, Edward Danso Ansong , Kofi Sarpong Adu-Manu, Winfred Yaokumah

    Journal of Cyber Security, Vol.8, pp. 33-92, 2026, DOI:10.32604/jcs.2026.074265 - 20 January 2026

    Abstract The rapid growth of digital payment systems and remote financial services has led to a significant increase in Card-Not-Present (CNP) fraud, which is now the primary source of card-related losses worldwide. Traditional rule-based fraud detection methods are becoming insufficient due to several challenges, including data imbalance, concept drift, privacy concerns, and limited interpretability. In response to these issues, a systematic review of twenty-four CNP fraud detection frameworks developed between 2014 and 2025 was conducted. This review aimed to identify the technologies, strategies, and design considerations necessary for adaptive solutions that align with evolving regulatory standards.… More >

  • Open Access

    REVIEW

    The Frontier of Melanoma Treatment: Defeating Immunotherapy Resistance—A Systematic Review

    Kamila Mozga1, Olga Synowiecka1, Igor Rydzyk1, Anna Marek1, Ewelina Wieczorek1, Alicja Petniak2,*, Paulina Gil-Kulik2

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070505 - 19 January 2026

    Abstract Objectives: Immunotherapy based on immune checkpoint blockade (ICB) has become a key treatment for melanoma. However, the increasing number of cases of melanoma resistant to immunotherapy highlights the need to develop methods to overcome this resistance. This study aims to collect the most recent information on melanoma immunotherapy, discuss potential strategies to overcome resistance to immunotherapy, and identify areas that require further analysis. Methods: To achieve this goal, scientific publications from 2021–2024 available in PubMed and Google Scholar databases were analyzed. The databases were searched using the following terms: “melanoma”, “immunotherapy”, “Immune Checkpoint Blockade”, and More >

  • Open Access

    REVIEW

    Unveiling the Anticancer Potential of Urolithin A in Colorectal Cancer: A Systematic Review

    Mariana Francisco1, Fernando Mendes1,2,3,4,5,*, Diana Martins1,2,3,4, Joana Liberal1,2

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070276 - 19 January 2026

    Abstract Objectives: Colorectal cancer (CRC) is a major global health burden, and Urolithin A (Uro-A) has emerged as a promising anticancer agent. This systematic review aims to synthesize current in vitro evidence on the anticancer effects of Uro-A in CRC, highlighting effective concentration ranges, exposure times, relevant outcomes, and underlying molecular mechanisms. Methods: Following PRISMA 2020 guidelines, a systematic search was conducted in PubMed, Scopus, and Web of Science using the following strategy: (colorectal cancer) AND (urolithin a) OR (3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one). Eligibility criteria were defined by the PICO framework: (P) in vitro CRC cell models; (I) Uro-A alone or… More > Graphic Abstract

    Unveiling the Anticancer Potential of Urolithin A in Colorectal Cancer: A Systematic Review

  • Open Access

    REVIEW

    The Efficacy and Safety of B-Cell Maturation Antigen (BCMA) Antibody-Drug Conjugates (ADC) in Development against Cancer: A Systematic Review

    Jing Shan1, Catherine King2,3, Harunor Rashid3,4, Veysel Kayser1,*

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070851 - 30 December 2025

    Abstract Objectives: B-cell maturation antigen (BCMA)-targeted antibody–drug conjugates (ADCs) have emerged as promising therapies for relapsed/refractory multiple myeloma (RRMM), but the overall efficacy and safety profile is unclear. This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM. Methods: A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024. Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes. Data extraction and quality assessments were conducted using validated tools, including ROBINS-I… More >

  • Open Access

    REVIEW

    Effectiveness and Safety of Lenvatinib and Everolimus after Immune Checkpoint Inhibitors in Metastatic Renal Cell Cancer: A Systematic Review

    Giacomo Iovane1,*, Luca Traman2, Michele Maffezzoli1,3, Giuseppe Fornarini2, Domenico Corradi4, Debora Guareschi4, Matteo Santoni5,#, Sebastiano Buti1,#

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070523 - 30 December 2025

    Abstract Background: While the treatment of metastatic renal cell carcinoma (mRCC) is evolving due to immune checkpoint inhibitors (ICIs), optimal strategies for later lines of therapy have yet to be defined. The combination of lenvatinib and everolimus represents a viable option, and the present review aimed to summarize its activity, effectiveness, and safety. Methods: A systematic review of the literature was conducted using PubMed, targeting studies published between 2018 and 2025. Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen. Results:More > Graphic Abstract

    Effectiveness and Safety of Lenvatinib and Everolimus after Immune Checkpoint Inhibitors in Metastatic Renal Cell Cancer: A Systematic Review

  • Open Access

    REVIEW

    Dual-Mode Data-Driven Iterative Learning Control: Applications in Precision Manufacturing and Intelligent Transportation Systems

    Lei Wang1,2, Menghan Wei2, Ziwei Huangfu3, Shunjie Zhu2, Xuejian Ge1,*, Zhengquan Li4

    CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-32, 2026, DOI:10.32604/cmc.2025.071295 - 09 December 2025

    Abstract Iterative Learning Control (ILC) provides an effective framework for optimizing repetitive tasks, making it particularly suitable for high-precision applications in both precision manufacturing and intelligent transportation systems (ITS). This paper presents a systematic review of ILC’s developmental progress, current methodologies, and practical implementations across these two critical domains. The review first analyzes the key technical challenges encountered when integrating ILC into precision manufacturing workflows. Through case studies, it evaluates demonstrated improvements in positioning accuracy, surface finish quality, and production throughput. Furthermore, the study examines ILC’s applications in ITS, with particular focus on vehicular motion control More >

  • Open Access

    REVIEW

    Deep Learning for Brain Tumor Segmentation and Classification: A Systematic Review of Methods and Trends

    Ameer Hamza, Robertas Damaševičius*

    CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-41, 2026, DOI:10.32604/cmc.2025.069721 - 10 November 2025

    Abstract This systematic review aims to comprehensively examine and compare deep learning methods for brain tumor segmentation and classification using MRI and other imaging modalities, focusing on recent trends from 2022 to 2025. The primary objective is to evaluate methodological advancements, model performance, dataset usage, and existing challenges in developing clinically robust AI systems. We included peer-reviewed journal articles and high-impact conference papers published between 2022 and 2025, written in English, that proposed or evaluated deep learning methods for brain tumor segmentation and/or classification. Excluded were non-open-access publications, books, and non-English articles. A structured search was… More >

  • Open Access

    REVIEW

    Machine Intelligence for Mental Health Diagnosis: A Systematic Review of Methods, Algorithms, and Key Challenges

    Ravita Chahar, Ashutosh Kumar Dubey*

    CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-65, 2026, DOI:10.32604/cmc.2025.066990 - 10 November 2025

    Abstract Objective: The increasing global prevalence of mental health disorders highlights the urgent need for the development of innovative diagnostic methods. Conditions such as anxiety, depression, stress, bipolar disorder (BD), and autism spectrum disorder (ASD) frequently arise from the complex interplay of demographic, biological, and socioeconomic factors, resulting in aggravated symptoms. This review investigates machine intelligence approaches for the early detection and prediction of mental health conditions. Methods: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) framework was employed to conduct a systematic review and analysis covering the period 2018 to 2025. The potential… More >

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