Junxun Ma, Lijie Wang, Jinyu Li, Guoqing Zhang, Haitao Tao, Xiaoyan Li, Danyang Sun, Yi Hu
Oncology Research, Vol.26, No.8, pp. 1207-1213, 2018, DOI:10.3727/096504017X15046134836575
Abstract Esophageal cancer is a common gastrointestinal cancer, with a very high mortality rate in patients with metastasis. Swainsonine, a cytotoxic fungal alkaloid, has been shown to inhibit cell growth in esophageal cancer.
In the present study, we explored the effects of swainsonine on cell invasion and metastasis in esophageal
cancer cells. Human esophageal carcinoma cells were treated with different doses of swainsonine, and then
cell viability, invasion, and apoptosis were measured. The mRNA and protein expressions of Twist1, apoptosis- and EMT-related factors, and PI3K/AKT pathway factors were detected by qRT-PCR and Western blot.
Swainsonine had More >
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