Dmytro A. Kiriziy¹, Oksana V. Dubrovna¹, Oksana G. Sokolovska-Sergiienko¹, Alina S. Holoboroda¹, Victor V. Rohach^1,2, Oleg O. Stasik^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.075371 - 30 January 2026

Abstract Water scarcity severely constrains the genetic potential of wheat yield worldwide. Proline is among the most versatile stress-related metabolites in plants, and targeting genes involved in proline synthesis and degradation represents a promising strategy for developing drought-tolerant wheat genotypes. This study evaluates the performance of the photosynthetic apparatus in transgenic wheat line with RNAi-mediated suppression of proline dehydrogenase (ProDH) and in the original (wild-type) genotype, under both drought and recovery conditions. Drought was induced at the flowering stage by lowering soil moisture to 30% field capacity for 7 days, compared with 70% field capacity in… More >

Yunpeng Wen^1,*, Bingyang Ke², Junrong Ding³

Chalcogenide Letters, Vol.23, No.1, 2026, DOI:10.32604/cl.2026.076587 - 26 January 2026

Abstract This study reports an active learning (AL)-guided strategy to optimize the sulfurization–selenization processing conditions of Sb₂(S,Se)₃ thin-film photovoltaic absorbers for enhanced power conversion efficiency (PCE). By coupling Gaussian process modeling with iterative experimental feedback, we explored 20 targeted annealing conditions across the full compositional spectrum (x = 0–1) and identified an optimal S/(S + Se) ratio of 0.40 (x = 0.60), which yielded a band gap (Eg) of ~1.34 eV, close to the theoretical Shockley–Queisser optimum. The optimized process employed a controlled two-step 420°C anneal with sequential H₂Se→H₂S exposure, which produced large plate-like grains (300–500 nm)… More >

Bu Zou^1,#, Yi-En Xu^2,#, Hui-Chan He³, Zu-Lu Ye², Da-Lei Zhou², Cai-Yun He^2,*, Chan Huang^4,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069453 - 19 January 2026

Abstract Objectives: Gastric cancer (GC) remains a major global health concern, and Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1), a regulatory subunit of the PI3K signaling pathway, may play a critical yet underexplored role in GC progression. This study aimed to investigate the prognostic significance of PIK3R1 in GC and its association with the tumor immune microenvironment. Methods: PIK3R1 expression and its clinical relevance were analyzed using datasets from GC patients who underwent gastrectomy, including cohorts from The Cancer Genome Atlas (TCGA) and the Sun Yat-sen University Cancer Center (SYSUCC). Prognostic models integrating PIK3R1 expression with clinical parameters… More >

Weichen Wang¹, Shaofeng Wang¹, Wenjing Liu^1,*, Luncai Zhou², Erqing Zhang¹, Ting Gao³, Grigory Petrishin⁴

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071278 - 08 January 2026

Abstract In dry-coupled ultrasonic thickness measurement, thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy. Existing methods struggle to resolve overlap-ping echoes under variable coupling conditions and non-stationary noise. This study proposes a novel dual-criterion framework integrating energy contribution and statistical impulsivity metrics to isolate specimen re-flections from coupling-layer interference. By decomposing A-scan signals into Intrinsic Mode Functions (IMFs), the framework employs energy contribution thresholds (>85%) and kurtosis indices (>3) to autonomously select IMFs containing valid specimen echoes. Hybrid time-frequency thresholding further suppresses interference through amplitude filtering and spectral focusing. More >

Yun Zhou^1,2, Shixiong Liu^1,2, Ya Zheng^1,3,4, Yuping Wang^1,3,4,*, Yongning Zhou^1,3,4,*

BIOCELL, Vol.49, No.10, pp. 1967-1983, 2025, DOI:10.32604/biocell.2025.069869 - 22 October 2025

Abstract Background: Gastric cancer (GC) is a prevalent cause of death. 3,9-Di-O-methylnissolin (DOM) is a flavonoid isolated from Astragalus membranaceus. It has anticancer and anti-inflammatory effects, but its effect and mechanism of action on GC are not very clear. Methods: The appropriate concentration was selected after observing the effects of varying concentrations of DOM on the viability of GC cells, which was examined through the cell counting kit-8 (CCK-8) assay. The receptor-interacting protein kinase 2 (RIPK2) overexpression plasmid was transfected into GC cells, which were then treated with DOM. Cell cycle and proliferation, RIPK2 levels, and inflammatory… More > Graphic Abstract

Junxing Chen^1,#, Luping Pan^1,#, Yunzhi Liu^1,2, Yan Fang¹, Ruoxuan Li¹, Zhiqin Lu^1,3, Anwen Liu^1,4, Yanqing He^5,*, Zhimin Zeng^1,6,*

Oncology Research, Vol.33, No.8, pp. 2107-2121, 2025, DOI:10.32604/or.2025.064237 - 18 July 2025

Abstract Background: Non-small cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM) have a very poor prognosis. Intrathecal pemetrexed (IP) has shown moderate efficacy in treating patients with NSCLC-LM. Myelosuppression is the most common adverse effect following IP administration. Despite this trend, the specific risk factors contributing to IP-related myelosuppression remain unclear. Methods: This study conducted a retrospective analysis of lung adenocarcinoma (LUAD) patients with LM who received IP treatment at the Second Affiliated Hospital of Nanchang University from April 2017 to April 2024. Risk factors for myelosuppression were identified through univariate and multivariate logistic regression… More >

Tianshuo Liu^1,2, Xiaoyu Cui¹, Lihao Lu^2,3, Kongkuai Ying^2,*, Yang Wang^2,3, Kangjun Liu², Zilong Wang¹, Zhenhua Jiang^2,3, Shaoshuai Liu^2,3,*

Frontiers in Heat and Mass Transfer, Vol.23, No.3, pp. 739-750, 2025, DOI:10.32604/fhmt.2025.064532 - 30 June 2025

Abstract Helium sorption cooler technology is a key means to realize highly reliable low-vibration very low-temperature environments, which have important applications in fields such as quantum computing and space exploration. The laboratory designed a superfluid suppression small hole and a multi-ribbed condenser, developed a reliable-performance helium sorption cooler (HSC), and conducted experimental studies. Experimental results show that the prototype can achieve the lowest cooling temperature of 873 mK without load by filling 6 MPa helium at room temperature. The low-temperature hold time is 26 h, and the temperature fluctuation is within 0.8 mK. The cooling power More >

Lihua Zuo^1,2,#, Jian Mao^2,#,*

Journal of Psychology in Africa, Vol.35, No.2, pp. 241-247, 2025, DOI:10.32604/jpa.2025.065765 - 30 June 2025

Abstract This study examined how social desirability responses confound the relationship between gender and social media addiction. A total of 496 college student social media users (females = 310, 62.5%, mean age = 20.15, SD = 1.26) completed an online questionnaire on Social Media Addiction and Social Desirability. Mediation analysis revealed that females were at higher risk for social media addiction. On the other hand, the indirect effect of gender on social media addiction via social desirability is associated with lower social media addiction, which suggests that social desirability had a suppression effect on social media More >

Qiang Guo^1,2,*, Rubo Zhang¹, Bingbing Zhang³

CMC-Computers, Materials & Continua, Vol.84, No.1, pp. 1307-1327, 2025, DOI:10.32604/cmc.2025.063288 - 09 June 2025

Abstract Pedestrian detection has been a hot spot in computer vision over the past decades due to the wide spectrum of promising applications, and the major challenge is false positives that occur during pedestrian detection. The emergence of various Convolutional Neural Network-based detection strategies substantially enhances pedestrian detection accuracy but still does not solve this problem well. This paper deeply analyzes the detection framework of the two-stage CNN detection methods and finds out false positives in detection results are due to its training strategy misclassifying some false proposals, thus weakening the classification capability of the following… More >

MIAO YAN¹, DONGXUAN CHI², WEN WANG³, PEI PEI⁴, MIN XIE¹, SHUANGLING LI^1,*

BIOCELL, Vol.49, No.5, pp. 893-906, 2025, DOI:10.32604/biocell.2025.063622 - 27 May 2025

Abstract Background: Transcription factor Krüppel-like factor 3 (KLF3) may be involved in regulating inflammation and lymphocyte function. Immune dysfunction in sepsis involves both hyper-inflammation and immunosuppression. However, studies on T-lymphocyte KLF3 expression in sepsis are lacking. Methods: We induced sepsis in mice via cecal ligation and puncture (CLP), and their survival rate over 7 days was evaluated. To identify the immune status of these mice, we assessed their cytokine levels, organ damage scores, and splenic T-lymphocyte phenotype. Finally, T-lymphocyte KLF3 expression was detected through flow cytometry. Results: Over the 7 days of observation, septic mice demonstrated 64.7%… More >