Oncology Research Editorial Office

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077268 - 30 December 2025

Abstract This article has no abstract. More >

Fangyuan Li^1,2,#, Xiaoyuan Hu^1,#, Xiaoge Gao³, Ling Liu³, Tao Li¹, Dan He¹, Jiaxing Cheng¹, Xiaobiao Ma¹, Li Li^1,*, Chunlei Ge^1,*, Hong Yao^1,*

Oncology Research, Vol.33, No.12, pp. 4029-4048, 2025, DOI:10.32604/or.2025.067628 - 27 November 2025

Abstract Background: Liver cancer stem cells (LCSCs) are recognized as pivotal drivers of hepatocellular carcinoma (HCC) progression; however, the molecular mechanisms maintaining their stem-like phenotype remain largely unresolved. This work investigates the role of prefoldin subunit 6-like protein (PFDN6L) in shaping LCSC traits and promoting or restraining HCC progression. Methods: PFDN6L, a cytoskeleton-associated chaperone, was studied using multiple in vitro assays—cell growth evaluation, cell cycle profiling, and spheroid culture—alongside analyses of stemness-associated markers (SOX2, CD133, CD44). Tumorigenic capacity was assessed in xenograft mouse models, and signaling pathway interrogation was performed to define underlying mechanisms. Results: In patient samples, More >

Yong Huang¹, Xiandeng Li¹, Qingling Jing¹, Qin Zhang¹, Chungui Huang^2,*

BIOCELL, Vol.49, No.11, pp. 2195-2216, 2025, DOI:10.32604/biocell.2025.072716 - 24 November 2025

Abstract Objective: Mesenchymal stem cells (MSCs) are important cells in bone tissue engineering. Bone morphogenetic protein-2 (BMP-2) effectively treats bone defects and nonunion. The purpose of this study is to investigate whether BMP-2 promotes bone formation and femoral fracture healing by inhibiting inflammation and promoting osteogenic differentiation of MSCs, in order to provide an experimental basis for developing more efficient fracture treatment strategies. Methods: Bone marrow-derived MSCs (BMSCs) were isolated from rats and treated with OE-BMP-2, the 5^′-adenosine monophosphate-activated protein kinase (AMPK) signal agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), and the inhibitor Compound C. Osteogenic differentiation was evaluated through… More >

Sotirios Charalampos Diamantoudis^1,#,*, Androulla N. Miliotou^2,#, Eleftheria Galatou², Stergiani Telliou³, Konstantinos Sideris⁴, Nikolaos Grigoriadis¹, Ioannis S. Vizirianakis^1,2,*

BIOCELL, Vol.49, No.10, pp. 1799-1858, 2025, DOI:10.32604/biocell.2025.067216 - 22 October 2025

Abstract Hematological cancer stem cells (HCSCs) is a subpopulation of cells within hematological cancers that, through their characteristics, enhance malignancy and render their therapy more challenging. By uncovering the underlying mechanisms behind characteristic properties such as self-renewal, immune evasion, and conventional therapy resistance, as well as the major differences between other cancers and physiological cells, new and alternative targets can be assessed for use in existing and novel immunotherapeutic interventions. Through the evaluation of the existing literature, one can realize that there have already been several studies addressing the use of stem cell transplantation (SCT), monoclonal More > Graphic Abstract

Gabriel Matheus Da Silva Batista, Lucas Pina Rodrigues, Andrey Jorge Serra^*

BIOCELL, Vol.49, No.10, pp. 1873-1885, 2025, DOI:10.32604/biocell.2025.067186 - 22 October 2025

Abstract Adipose-derived stem cells (ADSCs) therapy has emerged as a promising strategy for treating degenerative, inflammatory, and cardiometabolic diseases. In addition to their higher bioavailability in adipose tissue, ADSCs demonstrate superior activity in producing specific immune modulators and growth factors when compared to other stem cell types. The detrimental impact of heart failure (HF)—a condition that still lacks a fully effective therapy—has driven significant interest in the therapeutic potential of ADSCs. This interest is supported by robust evidence from experimental studies employing HF animal models. Accordingly, this review aims to explore the cardioprotective mechanisms through which More >

Chong Wang^*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.1, pp. 1-1, 2025, DOI:10.32604/icces.2025.012164

Abstract Please Creating mechanically robust tissue engineering scaffolds capable of delivering growth factors and stem cells in situ for hard tissue repair remains a significant challenge. Inspired by the spiral structure of ice cream, our group developed an advanced 3D printing technique known as cryogenic 3D printing to fabricate polyester-based scaffolds with embedded growth factors. This method utilizes water-in-oil (w/o) polyester emulsions containing growth factors as the printing ink, which is patterned onto a cryogenic substrate. The resulting scaffolds feature a hierarchically porous structure, allowing mesenchymal stem cells (MSCs) to easily attach and proliferate. Additionally, the… More >

Sae Hee Cheon¹, Sung-Whan Kim^2,3,*

BIOCELL, Vol.49, No.9, pp. 1697-1710, 2025, DOI:10.32604/biocell.2025.068743 - 25 September 2025

Abstract Objectives: Despite the considerable regenerative capacity exhibited by adipose-derived mesenchymal stem cells (ASCs), their genetic and molecular mechanisms remain incompletely understood. Methods: In this study, we analyzed the global gene expression profile of adipose-derived mesenchymal stem cells (ASCs) using microarray analysis and compared it with stromal vascular fraction (SVF) cells. Results: Microarray analysis revealed that ASCs express elevated levels of genes related to the extracellular matrix (ECM; extracellular matrix) and collagen, which are critical components of tissue remodeling and wound healing. Additionally, genes associated with cell growth, differentiation, motility, and plasticity were highly expressed. When compared… More >

Alejandro Javier Español^1,2,*, Yamila Sanchez¹, Sofia Volpi²

BIOCELL, Vol.49, No.8, pp. 1449-1480, 2025, DOI:10.32604/biocell.2025.068034 - 29 August 2025

Abstract Background: Triple-negative (TN) breast cancer, the most aggressive subtype of breast cancer, is usually treated with high doses of paclitaxel (PX), which induces resistance. To prevent this adverse effect, metronomic chemotherapy based on administering low doses of PX plus carbachol (Carb), a muscarinic acetylcholine receptor (mAChR) agonist, has emerged as an alternative. Other acetylcholine receptors also present in breast tissue are nicotinic ones. When activated by nicotine (Nic), these receptors can decrease the effectiveness of conventional chemotherapy. However, whether metronomic chemotherapy with PX and Carb is affected by Nic has not yet been described. This… More >

Fan Yang, Zhongbo Zhu, Lijuan Shi, Xiping Liu^*

BIOCELL, Vol.49, No.8, pp. 1413-1433, 2025, DOI:10.32604/biocell.2025.064982 - 29 August 2025

Abstract Gastric cancer remains a leading cause of cancer-related mortality worldwide, with its complex tumor microenvironment (TME) playing a crucial role in tumor initiation, progression, and therapeutic response. As key components of the TME, mesenchymal stem cells (MSCs) influence tumor cell proliferation, invasion, and treatment resistance through cytokine secretion, exosomal communication, and metabolic regulation. MSCs enhance cancer stemness and therapy resistance by modulating glycolysis and fatty acid oxidation (FAO), while also promoting tumor progression through immune modulation and interactions with surrounding microenvironmental elements. Despite their potential for therapeutic applications, the clinical use of MSCs in gastric… More >

Yiqin He^1,2, Chenhan Hu^1,2, Xiangshu Meng^1,2, Rundong Ma^1,2, Kexin Duan^1,2, Yu Guo^2,3, Changqing Liu^1,2, Caiyun Ma^1,2, Gaofeng Liu^1,2,*, Chunjing Wang^1,2,*

BIOCELL, Vol.49, No.6, pp. 1037-1055, 2025, DOI:10.32604/biocell.2025.064633 - 24 June 2025

Abstract Background: Mesenchymal stem cells (MSCs) have shown great potential in treating neurodegenerative diseases, including Parkinson’s disease (PD), due to their ability to differentiate into neurons and secrete neurotrophic factors. Genetic modification of MSCs for PD treatment has become a research focus. Methods: In this study, rat pulmonary mesenchymal stem cells (PMSCs) were transduced with lentiviral vectors carrying Lmx1a/NeuroD1 to establish genetically engineered PMSCs (LN-PMSCs) and induce their differentiation into dopaminergic neurons. The LN-PMSCs were then transplanted into the right medial forebrain bundle region of PD model rats prepared using the 6-Hydroxydopamine (6-OHDA) method. Four weeks… More >