SUNG HEE LIM^1,#, HEE JIN CHO^1,2,3,#, KYOUNG-MEE KIM⁴, HO YEONG LIM¹, WON KI KANG¹, JEEYUN LEE¹, YOUNG SUK PARK¹, HEE CHEOL KIM^5,*, SEUNG TAE KIM^1,*

Oncology Research, Vol.31, No.6, pp. 855-866, 2023, DOI:10.32604/or.2023.030374

Abstract Background: Although bevacizumab is an important treatment for metastatic colorectal cancer (CRC), not all patients with CRC benefit from it; in unselected patient populations, only modest survival benefits have been reported. Methods: We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identify biomarkers for a response to bevacizumab-containing treatment. The molecular analysis comprised whole-exome sequencing, ribonucleic acid sequencing, and a methylation array on patient tissues. Results: Genomic and molecular characterization was successfully conducted in 103 patients. Six of 103 CRC samples were hypermutated, and none of the non-hypermutant tumors were microsatellite unstable. Among those 103 patients, 89… More >

Hang Meng^1,*, Jiaxing Wu¹, Guangxing Wu¹, Kai Long¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.2, pp. 1-1, 2023, DOI:10.32604/icces.2023.09685

Abstract Wind energy is one of the most promising renewable energies in the world. To generate more electricity, the wind turbines are getting larger and larger in recent decades [1]. With the wind turbine size growing, the length of the blade is getting slender. The large deflections of slender wind turbine blade will inevitably lead to geometric nonlinearities [2], e.g. nonlinear coupling between torsion and deflection, which complicates the governing equations of motion. To simplify the solution of the nonlinear equations, in the current research, a novel finite-difference method was proposed to solve the nonlinear equations of static beam model for… More >

Junzhe Cui¹, Dechun Zhang¹, Peng Li^1,*, Yiren Yang¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.010401

Abstract This study investigates the static instability of a cracked plate in subsonic airflow. The plate model is an inverted cantilever plate, where its leading edge is free and the trailing edge the clamped. A mathematical model of the crack is developed using the Dirac function, while Theodorsen aerodynamic mode is applied for the fluid force. To account for angle discontinuity caused by cracks, Fourier expansion is employed to transform the form corresponding to the angle into a continuous model. The critical divergent dynamic pressure and mode of an inverted cantilever plate with a crack are calculated using the Galerkin method.… More >

Changyao Chen¹, Jialei Song^1,*, Ling Yin¹, Yizhe Li², Zheng Yuan², Yuhan Li³

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.09859

Abstract Bird can switch between high maneuverability and high stability due to its ability to substantially morph wings and tail. Tail as an auxiliary lift surface, plays an important role on lift and drag production and also significantly affects the longitudinal stability. In this study, we reconstruct a high-fidelity barn owl model using the point cloud of its surface obtained from high-speed photogrammetry, and simulate the fluid dynamics using a commercial software. By virtually manipulating the tail to a series of postures, we analyze the aerodynamics and static stability for each tail posture, investigating the strategy to adjust the stability during… More >

Xu Gao, Ziqi Shen, Jinliang Xu, Min Fan, Qiang Li^*

Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 1987-1999, 2023, DOI:10.32604/phyton.2023.027318

Abstract Phytophthora nicotianae causes substantial economic losses in most countries where tobacco is produced. At present, the control of P. nicotianae mainly depends on chemical methods, with considerable environmental and health issues. We investigated the effects of ethanol extracts from Scutellaria baicalensis Georgi (SBG) and Magnolia officinalis (MO). On mycelial growth, sporangium formation, and zoospore release of P. nicotianae. Both extracts inhibited the growth of P. nicotianae, with mycelial growth inhibition rates of 88.92% and 93.92%, respectively, at 40 mg/mL, and EC50 values of 5.39 and 5.74 mg/mL, respectively. The underlying mechanisms were the inhibition of sporangium formation, the reduction of… More >

FRANCISCO RAÚL BORZONE^1,*, MARÍA BELÉN GIORELLO¹, LEANDRO MARCELO MARTINEZ², MARÍA CECILIA SANMARTIN^1,3, LEONARDO FELDMAN⁴, FEDERICO DIMASE⁵, EMILIO BATAGELJ⁶, GUSTAVO YANNARELLI³, NORMA ALEJANDRA CHASSEING^1,*

Oncology Research, Vol.31, No.3, pp. 361-374, 2023, DOI:10.32604/or.2023.028104

Abstract Breast cancer is the predominant form of carcinoma among women worldwide, with 70% of advanced patients developing bone metastases, with a high mortality rate. In this sense, the bone marrow (BM) mesenchymal stem/stromal cells (MSCs) are critical for BM/bone homeostasis, and failures in their functionality, transform the BM into a pre-metastatic niche (PMN). We previously found that BM-MSCs from advanced breast cancer patients (BCPs, infiltrative ductal carcinoma, stage III-B) have an abnormal profile. This work aims to study some of the metabolic and molecular mechanisms underlying MSCs shift from a normal to an abnormal profile in this group of patients.… More >

ZICHEN SHAO^1,2,#, CHUNG-YI CHEN^3,#, XUZHOU CHEN¹, HANWU CHEN¹, MENGQIAO SU^1,2, HUI SUN^1,2, YIDAN LI^1,2, BINGHUA TU¹, ZITONG WANG¹, CHI-MING LIU^1,*

BIOCELL, Vol.47, No.6, pp. 1389-1396, 2023, DOI:10.32604/biocell.2023.028222

Abstract Background: Benign prostatic hyperplasia (BPH) is a common condition in middle-aged and elderly men. Enlargement of the prostate causes lower urinary tract symptoms. Capsaicin is a phytochemical extracted from chili peppers and exerts many pharmacological actions, such as anti-tumor and anti-inflammatory effects. Methods: Our study investigated the effect of capsaicin in vitro and in a mouse model in vivo. A prostatic stromal myofibroblast cell line (WPMY-1) was co-incubated with testosterone (1 µM) and different concentrations of capsaicin (10–100 µM) for 24 and 48 h. Capsaicin (10–100 µM) significantly inhibited testosterone-treated WPMY-1 cell growth at 48 h by MTT assay. The… More >

Kexin Zhang, Xinyuan Shen, Longsheng Bao, He Liu^*

Structural Durability & Health Monitoring, Vol.17, No.2, pp. 131-158, 2023, DOI:10.32604/sdhm.2023.023431

Abstract In this paper, the construction process of a cable-stayed bridge with corrugated steel webs was monitored. Moreover, the end performance of the bridge was verified by load test. Owing to the consideration of the bridge structure safety, it is necessary to monitor the main girder deflection, stress, construction error and safety state during construction. Furthermore, to verify whether the bridge can meet the design requirements, the static and dynamic load tests are carried out after the completion of the bridge. The results of construction monitoring show that the stress state of the structure during construction is basically consistent with the… More >

Shang Zhang¹, Jie Wang², Benjamin Rose⁵, Yushan Yang³, Qingfeng Ding¹, Bengang Zhang^4,*, Chunlei Dong^2,*

Journal of Renewable Materials, Vol.11, No.6, pp. 2881-2891, 2023, DOI:10.32604/jrm.2023.028160

Abstract To study the static bending creep properties of glass fiber reinforced wood, glass fiber reinforced poplar (GFRP) specimens were obtained by pasting glass fiber on the upper and lower surfaces of Poplar (Populus euramevicana, P), the performance of Normal Creep (NC) and Mechanical Sorptive Creep (MSC) of GFRP and their influencing factors were tested and analyzed. The test results and analysis show that: (1) The MOE and MOR of Poplar were increased by 17.06% and 10.00% respectively by the glass fiber surface reinforced composite. (2) The surface reinforced P with glass fiber cloth only exhibits the NC pattern of wood… More >

Dongmin Wang^1,2,*, Gaoshuai Lin¹

CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.1, pp. 299-318, 2023, DOI:10.32604/cmes.2023.027280

Abstract There are five most widely used contact angle schemes in the pseudopotential lattice Boltzmann (LB) model for simulating the wetting phenomenon: The pseudopotential-based scheme (PB scheme), the improved virtual-density scheme (IVD scheme), the modified pseudopotential-based scheme with a ghost fluid layer constructed by using the fluid layer density above the wall (MPB-C scheme), the modified pseudopotential-based scheme with a ghost fluid layer constructed by using the weighted average density of surrounding fluid nodes (MPB-W scheme) and the geometric formulation scheme (GF scheme). But the numerical stability and accuracy of the schemes for wetting simulation remain unclear in the past. In… More >