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  • Open Access

    ARTICLE

    Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

    Zhao-Jun Zhang1, Wen-Wei Wang1,2,*, Jing-Shui Zhen1, Bo-Cheng Li1, De-Cheng Cai1, Yang-Yang Du1, Hui Huang2

    Structural Durability & Health Monitoring, Vol.19, No.1, pp. 105-123, 2025, DOI:10.32604/sdhm.2024.052506 - 15 November 2024

    Abstract This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer (GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment zone. An experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs, and a calculation method based on the conjugate beam method was proposed. The composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab specimens. Two methods, epoxy resin bonding, and stud connection, were used to connect the composite… More >

  • Open Access

    ARTICLE

    Fuzzy Comprehensive Analysis of Static Mixers Used for Selective Catalytic Reduction in Diesel Engines

    Xin Luan1,*, Guoqing Su1, Hailong Chen1, Min Kuang1,2

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.11, pp. 2459-2473, 2024, DOI:10.32604/fdmp.2024.054621 - 28 October 2024

    Abstract The proper selection of a relevant mixer generally requires an effective assessment of several models against the application requirements. This is a complex task, as traditional evaluation methods generally focus only on a single aspect of performance, such as pressure loss, mixing characteristics, or heat transfer. This study assesses a urea-based selective catalytic reduction (SCR) system installed on a ship, where the installation space is limited and the distance between the urea aqueous solution injection position and the reactor is low; therefore, the static mixer installed in this pipeline has special performance requirements. In particular,… More >

  • Open Access

    ARTICLE

    Is ypTNM staging a comparable predictor as pTNM staging for survival in non-metastatic rectal cancer after preoperative chemoradiation therapy?

    JEN-PIN CHUANG1,2,3, HSIANG-LIN TSAI4,5, WEI-CHIH SU4,6,7, PO-JUNG CHEN4,6, CHING-WEN HUANG4,5, TSUNG-KUN CHANG4,6,7, YEN-CHENG CHEN4,6, CHING-CHUN LI4,8, YUNG-SUNG YEH4,9,10, TZU-CHIEH YIN4,5,11, JAW-YUAN WANG4,5,6,12,13,*

    Oncology Research, Vol.32, No.11, pp. 1723-1732, 2024, DOI:10.32604/or.2024.052098 - 16 October 2024

    Abstract Background: The pTNM staging system is widely recognized as the most effective prognostic indicator for cancer. The latest update of this staging system introduced a new pathological staging system (ypTNM) for patients receiving neoadjuvant chemoradiotherapy (NACRT). However, whether the prognostic value of the ypTNM staging system for rectal cancer is similar to that of the pTNM staging system remains unclear. This study was conducted to compare the ypTNM and pTNM staging systems in terms of their prognostic value for patients with nonmetastatic rectal cancer undergoing proctectomy. Material and Methods: This study was conducted at a large teaching… More >

  • Open Access

    PROCEEDINGS

    Static and Dynamic Fracture Toughness of Graphite Materials with Varying Grain Sizes

    Sihui Tong1, Boyuan Cao1, Dongqing Tian2, Qinwei Ma1, Guangyan Liu1,*, Li Shi2, Libin Sun2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.010870

    Abstract Graphite materials serve critical roles as moderators, reflectors and core structural components in high-temperature gas-cooled nuclear reactors. These materials may experience a variety of loads during the reactor operation, including thermal, radiation, fatigue and dynamic loads, potentially leading to crack initiation and propagation. Consequently, it is imperative to investigate the fracture properties of graphite materials. Currently, there exists a dearth of comprehensive studies on the fracture toughness of graphite materials with varying grain sizes, especially regarding dynamic fracture toughness. This study introduces a novel approach utilizing a digital-image-correlation-based virtual extensometer to analyze crack propagation in… More >

  • Open Access

    PROCEEDINGS

    Simple but Effective Heat Treatment on Hot Isostatic Press Diffusion Bonded Ni60A Hardfacing Layer

    Lei Yu1,2, Yingjie Yan1,2, Hao Dong3,4, Suk-Chun Moon5,*, Zhengyi Jiang5,*, Rui Cao1,2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.4, pp. 1-2, 2024, DOI:10.32604/icces.2024.011941

    Abstract Ni60A hardfacing alloy, as one of the highest-alloy grades and hardest alloy of Ni-Cr-B-Si alloys, is expected to be used as hardfacing alloy for thrust discs in nuclear main pumps to reduce friction, corrosion and erosion. Since mechanical properties of Ni-Cr-B-Si alloys are very sensitive to their defects and microstructures, heat treatment/remelting methods have been used to eliminate porosity and to modify microstructural heterogeneity. In our previous research, Ni60A hardfacing layer with high micro-hardness and excellent bonding strength has been fabricated onto 0Cr18Ni10Ti austenitic stainless steel using hot isostatic press diffusion bonding technique. However, some… More >

  • Open Access

    ARTICLE

    Quasi-Static and Low-Frequency Dynamic Mechanical Analysis Characterization of Graphene Nanoplatelets/Glass Fabric/Bisphenol-A-Based Epoxy Nanocomposites

    Santhanakrishnan Mamallan1, Venkateshwaran Narayanan1,*, Canungo Bhimarao Ragothaman2

    Journal of Polymer Materials, Vol.41, No.3, pp. 105-116, 2024, DOI:10.32604/jpm.2024.056744 - 30 September 2024

    Abstract Glass fabric/polymer composites are widely used in various industrial applications due to their lightweight, exceptional strength, and fatigue resistance. Graphene nanoplatelets, a recently developed type of carbon material, stand out as unique nanofillers due to their 2D quantum confinement and expansive surface area within a polymer matrix. These features make them more effective than traditional carbon nanofillers at enhancing a range of properties. In this study, 3-weight % of graphene nanoplatelets with epoxy resin were used for investigation by varying sonication durations (0, 20, 40, and 60 min) using an ultrasonic bath sonicator. The laminates More >

  • Open Access

    ARTICLE

    PD-1+ and TIM-3+ T cells widely express common γ-chain cytokine receptors in multiple myeloma patients, and IL-2, IL-7, IL-15 stimulation up-regulates PD-1 and TIM-3 on T cells

    EGOR V. BATOROV1,2,*, ALISA D. INESHINA2, TATIANA A. ARISTOVA3, VERA V. DENISOVA3, SVETLANA A. SIZIKOVA3, DARIA S. BATOROVA3, GALINA Y. USHAKOVA3, EKATERINA Y. SHEVELA1, ELENA R. CHERNYKH1

    Oncology Research, Vol.32, No.10, pp. 1575-1587, 2024, DOI:10.32604/or.2024.047893 - 18 September 2024

    Abstract Background: Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma (MM) progression. Simultaneously, previous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with common γ-chain family cytokines in vitro and during homeostatic proliferation. The aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets up-regulating PD-1 and TIM-3 checkpoint molecules. Methods: The expression of CD25, CD122, CD127 common γ-chain cytokine receptors, phosphorylated signal transducer and activator of transcription-5 (pSTAT5) and eomesodermin (EOMES) was comparatively assessed with flow… More >

  • Open Access

    ARTICLE

    The challenge of molecular selection in liver-limited metastatic colorectal cancer for surgical resection: a systematic review and meta-analysis in the context of current and future approaches

    ROSSANA RONCATO1,2, JERRY POLESEL3, FEDERICA TOSI4,5,*, ELENA PERUZZI1,*, ERIKA BRUGUGNOLI6, CLAUDIA LAURIA PANTANO7, MARIA FURFARO8, FILIPPO DI GIROLAMO9,10, ALESSANDRO NANI11, ARIANNA PANI4, NOEMI MILAN1, ELENA DE MATTIA1, ANDREA SARTORE-BIANCHI4,5, ERIKA CECCHIN1

    Oncology Research, Vol.32, No.9, pp. 1407-1422, 2024, DOI:10.32604/or.2024.049181 - 23 August 2024

    Abstract Objectives: Treatment of metastatic colorectal cancer (mCRC) includes resection of liver metastases (LM), however, no validated biomarker identifies patients most likely to benefit from this procedure. This meta-analysis aimed to assess the impact of the most relevant molecular alterations in cancer-related genes of CRC (i.e., RAS, BRAF, SMAD4, PIK3CA) as prognostic markers of survival and disease recurrence in patients with mCRC surgically treated by LM resection. Methods: A systematic literature review was performed to identify studies reporting data regarding survival and/or recurrence in patients that underwent complete liver resection for CRC LM, stratified according to… More > Graphic Abstract

    The challenge of molecular selection in liver-limited metastatic colorectal cancer for surgical resection: a systematic review and meta-analysis in the context of current and future approaches

  • Open Access

    ARTICLE

    A Hermitian C Differential Reproducing Kernel Interpolation Meshless Method for the 3D Microstructure-Dependent Static Flexural Analysis of Simply Supported and Functionally Graded Microplates

    Chih-Ping Wu*, Ruei-Syuan Chang

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.1, pp. 917-949, 2024, DOI:10.32604/cmes.2024.052307 - 20 August 2024

    Abstract This work develops a Hermitian C differential reproducing kernel interpolation meshless (DRKIM) method within the consistent couple stress theory (CCST) framework to study the three-dimensional (3D) microstructure-dependent static flexural behavior of a functionally graded (FG) microplate subjected to mechanical loads and placed under full simple supports. In the formulation, we select the transverse stress and displacement components and their first- and second-order derivatives as primary variables. Then, we set up the differential reproducing conditions (DRCs) to obtain the shape functions of the Hermitian C differential reproducing kernel (DRK) interpolant’s derivatives without using direct differentiation. The interpolant’s… More >

  • Open Access

    ARTICLE

    Software Vulnerability Mining and Analysis Based on Deep Learning

    Shibin Zhao*, Junhu Zhu, Jianshan Peng

    CMC-Computers, Materials & Continua, Vol.80, No.2, pp. 3263-3287, 2024, DOI:10.32604/cmc.2024.041949 - 15 August 2024

    Abstract In recent years, the rapid development of computer software has led to numerous security problems, particularly software vulnerabilities. These flaws can cause significant harm to users’ privacy and property. Current security defect detection technology relies on manual or professional reasoning, leading to missed detection and high false detection rates. Artificial intelligence technology has led to the development of neural network models based on machine learning or deep learning to intelligently mine holes, reducing missed alarms and false alarms. So, this project aims to study Java source code defect detection methods for defects like null pointer… More >

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