FRANCISCO RAÚL BORZONE^1,*, MARÍA BELÉN GIORELLO¹, LEANDRO MARCELO MARTINEZ², MARÍA CECILIA SANMARTIN^1,3, LEONARDO FELDMAN⁴, FEDERICO DIMASE⁵, EMILIO BATAGELJ⁶, GUSTAVO YANNARELLI³, NORMA ALEJANDRA CHASSEING^1,*

Oncology Research, Vol.31, No.3, pp. 361-374, 2023, DOI:10.32604/or.2023.028104

Abstract Breast cancer is the predominant form of carcinoma among women worldwide, with 70% of advanced patients developing bone metastases, with a high mortality rate. In this sense, the bone marrow (BM) mesenchymal stem/stromal cells (MSCs) are critical for BM/bone homeostasis, and failures in their functionality, transform the BM into a pre-metastatic niche (PMN). We previously found that BM-MSCs from advanced breast cancer patients (BCPs, infiltrative ductal carcinoma, stage III-B) have an abnormal profile. This work aims to study some of the metabolic and molecular mechanisms underlying MSCs shift from a normal to an abnormal profile in this group of patients.… More >

ZICHEN SHAO^1,2,#, CHUNG-YI CHEN^3,#, XUZHOU CHEN¹, HANWU CHEN¹, MENGQIAO SU^1,2, HUI SUN^1,2, YIDAN LI^1,2, BINGHUA TU¹, ZITONG WANG¹, CHI-MING LIU^1,*

BIOCELL, Vol.47, No.6, pp. 1389-1396, 2023, DOI:10.32604/biocell.2023.028222

Abstract Background: Benign prostatic hyperplasia (BPH) is a common condition in middle-aged and elderly men. Enlargement of the prostate causes lower urinary tract symptoms. Capsaicin is a phytochemical extracted from chili peppers and exerts many pharmacological actions, such as anti-tumor and anti-inflammatory effects. Methods: Our study investigated the effect of capsaicin in vitro and in a mouse model in vivo. A prostatic stromal myofibroblast cell line (WPMY-1) was co-incubated with testosterone (1 µM) and different concentrations of capsaicin (10–100 µM) for 24 and 48 h. Capsaicin (10–100 µM) significantly inhibited testosterone-treated WPMY-1 cell growth at 48 h by MTT assay. The… More >

Kexin Zhang, Xinyuan Shen, Longsheng Bao, He Liu^*

Structural Durability & Health Monitoring, Vol.17, No.2, pp. 131-158, 2023, DOI:10.32604/sdhm.2023.023431

Abstract In this paper, the construction process of a cable-stayed bridge with corrugated steel webs was monitored. Moreover, the end performance of the bridge was verified by load test. Owing to the consideration of the bridge structure safety, it is necessary to monitor the main girder deflection, stress, construction error and safety state during construction. Furthermore, to verify whether the bridge can meet the design requirements, the static and dynamic load tests are carried out after the completion of the bridge. The results of construction monitoring show that the stress state of the structure during construction is basically consistent with the… More >

Shang Zhang¹, Jie Wang², Benjamin Rose⁵, Yushan Yang³, Qingfeng Ding¹, Bengang Zhang^4,*, Chunlei Dong^2,*

Journal of Renewable Materials, Vol.11, No.6, pp. 2881-2891, 2023, DOI:10.32604/jrm.2023.028160

Abstract To study the static bending creep properties of glass fiber reinforced wood, glass fiber reinforced poplar (GFRP) specimens were obtained by pasting glass fiber on the upper and lower surfaces of Poplar (Populus euramevicana, P), the performance of Normal Creep (NC) and Mechanical Sorptive Creep (MSC) of GFRP and their influencing factors were tested and analyzed. The test results and analysis show that: (1) The MOE and MOR of Poplar were increased by 17.06% and 10.00% respectively by the glass fiber surface reinforced composite. (2) The surface reinforced P with glass fiber cloth only exhibits the NC pattern of wood… More >

Dongmin Wang^1,2,*, Gaoshuai Lin¹

CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.1, pp. 299-318, 2023, DOI:10.32604/cmes.2023.027280

Abstract There are five most widely used contact angle schemes in the pseudopotential lattice Boltzmann (LB) model for simulating the wetting phenomenon: The pseudopotential-based scheme (PB scheme), the improved virtual-density scheme (IVD scheme), the modified pseudopotential-based scheme with a ghost fluid layer constructed by using the fluid layer density above the wall (MPB-C scheme), the modified pseudopotential-based scheme with a ghost fluid layer constructed by using the weighted average density of surrounding fluid nodes (MPB-W scheme) and the geometric formulation scheme (GF scheme). But the numerical stability and accuracy of the schemes for wetting simulation remain unclear in the past. In… More >

Feezan Ahmad¹, Xiaowei Tang¹, Jilei Hu^2,*, Mahmood Ahmad^3,4, Behrouz Gordan⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.1, pp. 455-487, 2023, DOI:10.32604/cmes.2023.025993

Abstract Slope stability prediction plays a significant role in landslide disaster prevention and mitigation. This paper’s reduced error pruning (REP) tree and random tree (RT) models are developed for slope stability evaluation and meeting the high precision and rapidity requirements in slope engineering. The data set of this study includes five parameters, namely slope height, slope angle, cohesion, internal friction angle, and peak ground acceleration. The available data is split into two categories: training (75%) and test (25%) sets. The output of the RT and REP tree models is evaluated using performance measures including accuracy (Acc), Matthews correlation coefficient (Mcc), precision… More >

Salvatore Brischetto^*, Roberto Torre, Domenico Cesare

CMES-Computer Modeling in Engineering & Sciences, Vol.136, No.3, pp. 2551-2594, 2023, DOI:10.32604/cmes.2023.026312

Abstract This new work aims to develop a full coupled thermomechanical method including both the temperature profile and displacements as primary unknowns of the model. This generic full coupled 3D exact shell model permits the thermal stress investigation of laminated isotropic, composite and sandwich structures. Cylindrical and spherical panels, cylinders and plates are analyzed in orthogonal mixed curved reference coordinates. The 3D equilibrium relations and the 3D Fourier heat conduction equation for spherical shells are coupled and they trivially can be simplified in those for plates and cylindrical panels. The exponential matrix methodology is used to find the solutions of a… More >

Jikang Xu^1,4, Ruichuan Li^1,2,*, Yi Cheng², Yanchao Li³, Junru Yang³, Chenyu Feng⁴, Xinkai Ding², Huazhong Zhang⁵

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.7, pp. 1817-1836, 2023, DOI:10.32604/fdmp.2023.022602

Abstract Electro-hydraulic proportional valve is the core control valve in many hydraulic systems used in agricultural and engineering machinery. To address the problem related to the large throttling losses and poor stability typically associated with these valves, here, the beneficial effects of a triangular groove structure on the related hydraulic response are studied. A mathematical model of the pressure compensation system based on the power-bond graph method is introduced, and the AMESim software is used to simulate its response. The results show that the triangular groove structure increases the jet angle and effectively compensates for the hydrodynamic force. The steady-state differential… More > Graphic Abstract

YUNG-SUNG YEH^1,2,3, HSIANG-LIN TSAI^4,5, YEN-CHENG CHEN^4,6, WEI-CHIH SU^4,6, PO-JUNG CHEN^4,6, TSUNG-KUN CHANG^4,6,7, CHING-CHUN LI⁴, CHING-WEN HUANG^4,5, JAW-YUAN WANG^{4,5,6,8,9,10,*}

Oncology Research, Vol.30, No.2, pp. 65-76, 2022, DOI:10.32604/or.2022.026659

Abstract The controversial outcomes in patients with metastatic colorectal cancer (mCRC) highlight the need for developing effective systemic neoadjuvant treatment strategies to improve clinical results. The optimal treatment cycles in patients with mCRC for metastasectomy remain undefined. This retrospective study compared the efficacy, safety, and survival of cycles of neoadjuvant chemotherapy/targeted therapy for such patients. Sixty-four patients with mCRC who received neoadjuvant chemotherapy/targeted therapy following metastasectomy were enrolled between January 2018 and April 2022. Twenty-eight patients received 6 cycles of chemotherapy/targeted therapy, whereas 36 patients received ≥7 cycles (median, 13; range, 7–20). Clinical outcomes, including response, progression-free survival (PFS), overall survival… More >

Mohamed Elnagi¹, Salah Kamel², Abdelhady Ramadan², Mohamed F. Elnaggar^3,4,*

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 5229-5250, 2023, DOI:10.32604/cmc.2023.032469

Abstract Renewable energy sources are gaining popularity, particularly photovoltaic energy as a clean energy source. This is evident in the advancement of scientific research aimed at improving solar cell performance. Due to the non-linear nature of the photovoltaic cell, modeling solar cells and extracting their parameters is one of the most important challenges in this discipline. As a result, the use of optimization algorithms to solve this problem is expanding and evolving at a rapid rate. In this paper, a weIghted meaN oF vectOrs algorithm (INFO) that calculates the weighted mean for a set of vectors in the search space has… More >