Marco Siringo^1,2,#,*, Michela De Meo^1,#, Alain Jonathan Gelibter³, Chiara Nicolazzo^4,5,§, Paola Gazzaniga^5,§

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069832 - 19 January 2026

Abstract Objectives: Although immune checkpoint inhibitors (ICIs) and targeted therapies have reshaped treatment non-small cell lung cancer (NSCLC) paradigms, prognosis remains poor for many patients due to delayed diagnosis and resistance mechanisms. Liquid biopsy offers a minimally invasive approach to monitoring tumor evolution. Among circulating biomarkers, circulating tumor cells (CTCs) and cancer-associated macrophage-like cells (CAM-Ls) may provide complementary prognostic insights. The study aimed to evaluate the prognostic role of CTC and CAM-Ls dynamic in metastatic NSCLC patients. Methods: We retrospectively analyzed 77 patients with metastatic NSCLC who underwent CTC and CAM-L evaluation via the CellSearch® system… More >

Andong Cheng^1,2,#, Yiding Chen^1,#, Hao Li¹, Feixiang Yang¹, Junlan Jiang³, Sheng Tai¹, Weiwei Chen⁴, Yu Guan¹, Shuiping Yin^1,*, Jialin Meng^1,2,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.066478 - 19 January 2026

Abstract Background: In clinical practice, approximately 80% of prostate cancer (PC) cases are localized and can achieve favorable outcomes with appropriate treatment. Conversely, some remaining cases exhibit an aggressive phenotype or develop resistance to therapeutic interventions, leading to tumor metastasis and a poorer prognosis. When PC metastasizes to distant sites, the bone remains the predominant location, and brain metastases are regarded as exceedingly rare. Case Description: The current study focused on a rare clinical PC case that presented multiple brain metastases after prostate surgery. The patient was initially diagnosed with PC through prostate biopsy and subsequently underwent More >

José Armando Santas Ciavatta, Juan Ramón Bermejo Higuera^*, Javier Bermejo Higuera, Juan Antonio Sicilia Montalvo, Tomás Sureda Riera, Jesús Pérez Melero

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.074566 - 12 January 2026

Abstract As artificial Intelligence (AI) continues to expand exponentially, particularly with the emergence of generative pre-trained transformers (GPT) based on a transformer’s architecture, which has revolutionized data processing and enabled significant improvements in various applications. This document seeks to investigate the security vulnerabilities detection in the source code using a range of large language models (LLM). Our primary objective is to evaluate the effectiveness of Static Application Security Testing (SAST) by applying various techniques such as prompt persona, structure outputs and zero-shot. To the selection of the LLMs (CodeLlama 7B, DeepSeek coder 7B, Gemini 1.5 Flash,… More >

Keiko Yanagihara^1,*, Masato Yoshida², Kensaku Awaji², Tamami Yamakawa¹, Sena Kato¹, Miki Tamura¹, Koji Nagata³

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.073891 - 30 December 2025

Abstract Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have transformed the management of hormone receptor–positive/HER2–negative (HR+/HER2–) advanced breast cancer, yet evidence for elderly or poor-performance patients remains limited. This study examined real-world outcomes of palbociclib plus endocrine therapy in Asian patients, with additional subgroup analyses by age and performance status. Methods: We retrospectively analyzed 46 consecutive Asian patients with recurrent or de novo HR+/HER2− breast cancer treated with first-line palbociclib plus ET between April 2021 and March 2025. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall response rate (ORR), disease control rate (DCR), and safety.… More >

Giacomo Iovane^1,*, Luca Traman², Michele Maffezzoli^1,3, Giuseppe Fornarini², Domenico Corradi⁴, Debora Guareschi⁴, Matteo Santoni^5,#, Sebastiano Buti^1,#

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070523 - 30 December 2025

Abstract Background: While the treatment of metastatic renal cell carcinoma (mRCC) is evolving due to immune checkpoint inhibitors (ICIs), optimal strategies for later lines of therapy have yet to be defined. The combination of lenvatinib and everolimus represents a viable option, and the present review aimed to summarize its activity, effectiveness, and safety. Methods: A systematic review of the literature was conducted using PubMed, targeting studies published between 2018 and 2025. Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen. Results:… More > Graphic Abstract

Sandra Kałużna^1,*, Monika Świerczewska^1,2, Sylwia Ciesiółka¹, Małgorzata Partyka¹, Michał Nowicki¹, Karolina Wojtowicz¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070356 - 30 December 2025

Abstract The last research focuses on the role of exosomes in cancer treatment. Exosomes are extracellular vesicles. They can be secreted by cancer cells, and they can modulate chemotherapy sensitivity. Determining exosomal content opens the possibility for guiding treatment strategies for cancer diseases. Exosomal microRNA are considered one of the prime candidates for exosomal biomarkers. Exosomal circular RNAs represent excellent biomarkers for liquid biopsy because of their stability in many types of cancer. Exosomal proteins remain reliable biomarkers also. Exosomes have emerged as promising therapeutic candidates. Their biological properties render them ideal vectors for drug delivery.… More >

Huixin Wei, Baopeng Liao^*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.34, No.1, pp. 1-1, 2025, DOI:10.32604/icces.2025.012367

Abstract Friction behavior at soft-hard material interfaces plays a pivotal role in applications spanning biomedical devices, robotics, and tactile systems. While theoretical frameworks and experimental characterization methods have advanced, it is still difficult to unravel interfacial mechanisms. In this study, a theoretical model is firstly developed to predict static-to-sliding transitions by analyzing geometric evolution and stick-slip dynamics at soft material interfaces. The model quantitatively determines the threshold force for slip initiation, offering predictive insights into The sliding behavior of the interface. Second, an innovative tribometry platform is introduced, combining synchronized optical visualization, mechanical loading, and automated More >

Mengjie Wang¹, Jingfa Li^2,*, Bo Yu², Nianrong Wang³, Xiaofeng Wang³, Tao Hu⁴

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 3055-3072, 2025, DOI:10.32604/fdmp.2025.071675 - 31 December 2025

Abstract The adaptation of existing natural gas pipelines for hydrogen transportation has attracted increasing attention in recent years. Yet, whether hydrogen and natural gas stratify under static conditions remains a subject of debate, and experimental evidence is still limited. This study presents an experimental investigation of the concentration distribution of hydrogen–natural gas mixtures under static conditions. Hydrogen concentration was measured using a KTL-2000M-H hydrogen analyzer, with a measurement range of 0–30% (by volume), an accuracy of 1% full scale (FS), and a resolution of 0.01%. Experiments were conducted in a 300 cm riser, filled with uniformly… More >

Xingkang Jiang^*, Jing Tian, Yong Xu

Canadian Journal of Urology, Vol.32, No.6, pp. 539-540, 2025, DOI:10.32604/cju.2025.073363 - 30 December 2025

Abstract This article has no abstract. More >

Chuang Meng^1,*, Yutong Bi¹, Bingji Zhang¹, Wentao Fu², Guang Chen³

Structural Durability & Health Monitoring, Vol.19, No.6, pp. 1681-1694, 2025, DOI:10.32604/sdhm.2025.068732 - 17 November 2025

Abstract The lift-and-transverse type parking equipment, with its core advantages such as high space utilization, modular and flexible layout, and intelligent operation, has become an efficient solution to alleviate the urban parking problem. However, existing research still lacks a systematic evaluation of its structural performance, particularly in areas such as the fatigue characteristics of steel frame materials, stress distribution under dynamic loads, and resonance risk analysis. The stress amplitude (S) and fatigue life (N) relationship curve of Q235 steel, the material used in the steel frame of the lift-and-transverse type parking equipment, was obtained through fatigue… More >