Zhi-jian Meng*, Ke Tao†
Oncology Research, Vol.23, No.1-2, pp. 35-41, 2015, DOI:10.3727/096504015X14452563486057
Abstract Reports show that the stathmin gene may have a close relationship with tumor chemotherapeutic sensitivity.
However, the effect of stathmin-1 on the chemosensitivity of gastric cancer to docetaxel has not been clearly
determined. siRNA targeting stathmin-1 was introduced. The cell growth inhibition, expression of associated
proteins, cell cycle, and apoptosis were evaluated by MTT, Western blot, and flow cytometric assays, respectively. The influence of silencing stathmin-1 was detected in situ and in vivo. SGC7901/docetaxel cells are the
drug-resistant cells. After silencing stathmin-1, the resistance index (RI) reduced to 3.41, the expressions of
STMN-1, MDR1, and More >
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