Chunling Yan^1,2, Renzhang Yan^1,2,*, Zhenxiu Zhan¹, Xiyang Chen¹, Yu Han³

Structural Durability & Health Monitoring, Vol.19, No.4, pp. 1037-1056, 2025, DOI:10.32604/sdhm.2025.058780 - 30 June 2025

Abstract The steel tube arch rib in a large-span concrete-filled steel tube arch bridge has a large span and diameter, which also leads to a larger weld seam scale. Large-scale welding seams will inevitably cause more obvious welding residual stress (WRS). For the purpose of studying the influence of WRS from large-scale welding seam on the mechanical properties of steel tube arch rib during arch rib splicing, test research and numerical simulation analysis on the WRS in arch rib splicing based on the Guangxi Pingnan Third Bridge, which is the world’s largest span concrete-filled steel… More >

WENYING ZHENG^1,#, YANYAN SHANG^1,#, KAI DU¹, AILING LUO¹, LIJUN PEI¹, MEIQI LI¹, GUOPING ZHANG^2,*, MIN DENG^1,*

Oncology Research, Vol.33, No.5, pp. 1121-1133, 2025, DOI:10.32604/or.2025.060958 - 18 April 2025

Abstract Background: Alterations in splicing factors contribute to aberrant alternative splicing (AS), which subsequently promotes tumor progression. The splicing factor polypyrimidine tract binding protein 1 (PTBP1) has been shown to facilitate cancer progression by modulating oncogenic variants. However, its specific role and underlying mechanisms in hepatocellular carcinoma (HCC) remain to be elucidated. Methods: PTBP1 expression was evaluated in HCC tissues and cell lines. Subsequently, cells were transfected with vectors designed for PTBP1 overexpression or downregulation. The biological function of PTBP1 was assessed in vitro and in vivo using MTS assays, colony formation assays, transwell assays, xenograft formation, tail… More > Graphic Abstract

MING YANG^1,#, LIANGZHAO CHU^1,#, SHUKAI LIN², HAN PENG¹, NIYA LONG¹, KAYA XU¹, HUA YANG¹, FENG HAN^1,*, JIAN LIU^1,*

Oncology Research, Vol.33, No.5, pp. 1189-1198, 2025, DOI:10.32604/or.2024.055102 - 18 April 2025

Abstract Background: Glioblastoma (GBM) is one of the most malignant types of central nervous system tumors. Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression. However, the mechanisms of hypoxia-promoted tumor progression remain elusive. Methods: Alternative splicing of diacylglycerol kinase gamma (DGKG)-Δ exon13 was amplified and verified by PCR-Sanger sequencing. The functions of DGKG and DGKG-Δ exon13 were analyzed by Cell counting kit-8 (CCK-8), Transwell, Matrigel-transwell experiments, and in vivo orthotropic GBM animal models. Transcriptome analyses were done to find out the regulated genes. Results: In this study, we found… More > Graphic Abstract

YARU DU^1,2,#, ZHIHUI PEI^1,3,#, SHUQIN HU⁴, CHUANWEN LIAO¹, SHUHAO LIU^1,*

Oncology Research, Vol.33, No.2, pp. 309-325, 2025, DOI:10.32604/or.2024.058273 - 16 January 2025

Abstract Objectives: KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein involved in several cellular processes, including nuclear splicing, mRNA localization, and cytoplasmic degradation. While KHSRP’s role has been studied in other cancers, its specific involvement in gastric cancer remains poorly understood. This study aims to explore KHSRP expression in gastric cancer and its potential effects on tumor progression and immune response. Methods: KHSRP expression in gastric cancer tissues and normal tissues was analyzed using data from The Cancer Genome Atlas (TCGA) database. The correlation between KHSRP expression, patient survival, and immune response was also assessed.… More >

QINGYANG ZHANG, SHUXIAN HUANG, DAN WENG^*

BIOCELL, Vol.48, No.10, pp. 1443-1453, 2024, DOI:10.32604/biocell.2024.053794 - 02 October 2024

Abstract Huntington’s disease (HD) is a debilitating neurodegenerative disorder caused by an abnormal expansion of CAG repeats (Cytosine, Adenine, Guanine) in the huntingtin gene (HTT). This mutation leads to the production of a mutant huntingtin protein, resulting in neuronal dysfunction and cell death. Current treatments primarily focus on symptomatic relief and do not address the underlying genetic cause. This review explores spliceosome-mediated RNA trans-splicing (SMaRT) therapy as an innovative and potential approach for HD treatment. SMaRT leverages the cell’s natural splicing machinery to correct mutant mRNA, thereby reducing toxic protein levels while restoring functional protein production. We More >

Li Li^*, Youran Kong, Qing Zhang

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 551-567, 2024, DOI:10.32604/cmc.2023.045512 - 30 January 2024

Abstract With the growth of the Internet, more and more business is being done online, for example, online offices, online education and so on. While this makes people’s lives more convenient, it also increases the risk of the network being attacked by malicious code. Therefore, it is important to identify malicious codes on computer systems efficiently. However, most of the existing malicious code detection methods have two problems: (1) The ability of the model to extract features is weak, resulting in poor model performance. (2) The large scale of model data leads to difficulties deploying on… More >

Ala’a R. Al-Shamasneh¹, Rabha W. Ibrahim^2,3,4,*

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 795-810, 2024, DOI:10.32604/cmc.2023.042755 - 30 January 2024

Abstract The growing prevalence of fake images on the Internet and social media makes image integrity verification a crucial research topic. One of the most popular methods for manipulating digital images is image splicing, which involves copying a specific area from one image and pasting it into another. Attempts were made to mitigate the effects of image splicing, which continues to be a significant research challenge. This study proposes a new splicing detection model, combining Sonine functions-derived convex-based features and deep features. Two stages make up the proposed method. The first step entails feature extraction, then… More >

Arslan Akram^1,3, Javed Rashid^2,3,4, Arfan Jaffar¹, Fahima Hajjej⁵, Waseem Iqbal⁶, Nadeem Sarwar^7,*

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 145-166, 2024, DOI:10.32604/cmc.2023.041074 - 30 January 2024

Abstract Today’s forensic science introduces a new research area for digital image analysis for multimedia security. So, Image authentication issues have been raised due to the wide use of image manipulation software to obtain an illegitimate benefit or create misleading publicity by using tempered images. Exiting forgery detection methods can classify only one of the most widely used Copy-Move and splicing forgeries. However, an image can contain one or more types of forgeries. This study has proposed a hybrid method for classifying Copy-Move and splicing images using texture information of images in the spatial domain. Firstly, More >

TING ZHOU^1,#, PEIYING FU^1,#, DONG CHEN², RONGHUA LIU^1,*

Oncology Research, Vol.31, No.5, pp. 769-785, 2023, DOI:10.32604/or.2023.030166 - 21 July 2023

Abstract Late-stage ovarian cancer (OC) has a poor prognosis and a high metastasis rate, but the underlying molecular mechanism is unclear. RNA binding proteins (RBPs) play important roles in posttranscriptional regulation in the contexts of neoplasia and tumor metastasis. In this study, we explored the molecular functions of a canonical RBP, Transformer 2β homolog (TRA2B), in cancer cells. TRA2B knockdown in HeLa cells and subsequent whole-transcriptome RNA sequencing (RNA-seq) analysis revealed the TRA2B-regulated alternative splicing (AS) profile. We disrupted TRA2B expression in epithelial OC cells and performed a series of experiments to confirm the resulting effects… More >

LAURA MARRONE¹, MASSIMO D’AGOSTINO¹, CAROLINA GIORDANO², VALERIA DI GIACOMO¹, SIMONA URZINI¹, CHIARA MALASOMMA¹, MARIA PAOLA GAMMELLA¹, MARTINA TUFANO¹, SIMONA ROMANO^1,*, MARIA FIAMMETTA ROMANO^1,*

Oncology Research, Vol.31, No.4, pp. 423-436, 2023, DOI:10.32604/or.2023.028392 - 25 June 2023

Abstract Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. Among the scaffold proteins, immunophilin covers a unique role as ‘protein-philin’ (Greek ‘philin’ = friend) that interacts with proteins to guide their proper assembly. The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic properties. Among the members of the immunophilin family, the FKBP5 gene was the only one identified to have a splicing variant. More > Graphic Abstract