QINGYANG ZHANG, SHUXIAN HUANG, DAN WENG^*

BIOCELL, Vol.48, No.10, pp. 1443-1453, 2024, DOI:10.32604/biocell.2024.053794 - 02 October 2024

Abstract Huntington’s disease (HD) is a debilitating neurodegenerative disorder caused by an abnormal expansion of CAG repeats (Cytosine, Adenine, Guanine) in the huntingtin gene (HTT). This mutation leads to the production of a mutant huntingtin protein, resulting in neuronal dysfunction and cell death. Current treatments primarily focus on symptomatic relief and do not address the underlying genetic cause. This review explores spliceosome-mediated RNA trans-splicing (SMaRT) therapy as an innovative and potential approach for HD treatment. SMaRT leverages the cell’s natural splicing machinery to correct mutant mRNA, thereby reducing toxic protein levels while restoring functional protein production. We More >

Li Li^*, Youran Kong, Qing Zhang

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 551-567, 2024, DOI:10.32604/cmc.2023.045512 - 30 January 2024

Abstract With the growth of the Internet, more and more business is being done online, for example, online offices, online education and so on. While this makes people’s lives more convenient, it also increases the risk of the network being attacked by malicious code. Therefore, it is important to identify malicious codes on computer systems efficiently. However, most of the existing malicious code detection methods have two problems: (1) The ability of the model to extract features is weak, resulting in poor model performance. (2) The large scale of model data leads to difficulties deploying on… More >

Ala’a R. Al-Shamasneh¹, Rabha W. Ibrahim^2,3,4,*

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 795-810, 2024, DOI:10.32604/cmc.2023.042755 - 30 January 2024

Abstract The growing prevalence of fake images on the Internet and social media makes image integrity verification a crucial research topic. One of the most popular methods for manipulating digital images is image splicing, which involves copying a specific area from one image and pasting it into another. Attempts were made to mitigate the effects of image splicing, which continues to be a significant research challenge. This study proposes a new splicing detection model, combining Sonine functions-derived convex-based features and deep features. Two stages make up the proposed method. The first step entails feature extraction, then… More >

Arslan Akram^1,3, Javed Rashid^2,3,4, Arfan Jaffar¹, Fahima Hajjej⁵, Waseem Iqbal⁶, Nadeem Sarwar^7,*

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 145-166, 2024, DOI:10.32604/cmc.2023.041074 - 30 January 2024

Abstract Today’s forensic science introduces a new research area for digital image analysis for multimedia security. So, Image authentication issues have been raised due to the wide use of image manipulation software to obtain an illegitimate benefit or create misleading publicity by using tempered images. Exiting forgery detection methods can classify only one of the most widely used Copy-Move and splicing forgeries. However, an image can contain one or more types of forgeries. This study has proposed a hybrid method for classifying Copy-Move and splicing images using texture information of images in the spatial domain. Firstly, More >

TING ZHOU^1,#, PEIYING FU^1,#, DONG CHEN², RONGHUA LIU^1,*

Oncology Research, Vol.31, No.5, pp. 769-785, 2023, DOI:10.32604/or.2023.030166 - 21 July 2023

Abstract Late-stage ovarian cancer (OC) has a poor prognosis and a high metastasis rate, but the underlying molecular mechanism is unclear. RNA binding proteins (RBPs) play important roles in posttranscriptional regulation in the contexts of neoplasia and tumor metastasis. In this study, we explored the molecular functions of a canonical RBP, Transformer 2β homolog (TRA2B), in cancer cells. TRA2B knockdown in HeLa cells and subsequent whole-transcriptome RNA sequencing (RNA-seq) analysis revealed the TRA2B-regulated alternative splicing (AS) profile. We disrupted TRA2B expression in epithelial OC cells and performed a series of experiments to confirm the resulting effects… More >

LAURA MARRONE¹, MASSIMO D’AGOSTINO¹, CAROLINA GIORDANO², VALERIA DI GIACOMO¹, SIMONA URZINI¹, CHIARA MALASOMMA¹, MARIA PAOLA GAMMELLA¹, MARTINA TUFANO¹, SIMONA ROMANO^1,*, MARIA FIAMMETTA ROMANO^1,*

Oncology Research, Vol.31, No.4, pp. 423-436, 2023, DOI:10.32604/or.2023.028392 - 25 June 2023

Abstract Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. Among the scaffold proteins, immunophilin covers a unique role as ‘protein-philin’ (Greek ‘philin’ = friend) that interacts with proteins to guide their proper assembly. The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic properties. Among the members of the immunophilin family, the FKBP5 gene was the only one identified to have a splicing variant. More > Graphic Abstract

Shaochun Liu, Jiamin Hu, Haohua He, Junru Fu, Xu Jie, Dahu Zhou^*, Haihui Fu^*

Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 2035-2049, 2023, DOI:10.32604/phyton.2023.028296 - 29 May 2023

Abstract OsPLS4 encodes a β-ketoacyl carrier protein reductase (KAR). The role of OsPLS4 in rice sheath blight (Rhizoctonia solani) remains unclear. Our preliminary studies showed that premature leaf senescence mutants (pls4) were highly susceptive to sheath blight in the early stage of rice development. To explore the role of this gene in the development of rice sheath blight, the transcriptome profiles of the rice pls4 mutant and wild type were compared by RNA-seq. The results revealed 2,569 differentially expressed genes (DEGs). The down-regulated genes were significantly enriched in the defense response-related biological processes. These down-regulated genes included the chitinase… More >

Xinyi Zhang, Zimeng Yu, Pingfang Yang^*

Phyton-International Journal of Experimental Botany, Vol.92, No.6, pp. 1665-1679, 2023, DOI:10.32604/phyton.2023.029482 - 11 April 2023

Abstract Sacred lotus (Nelumbo nucifera) is a typical aquatic plant, belonging to basal eudicot plant, which is ideal for genome and genetic evolutionary study. Understanding lotus gene diversity is important for the study of molecular genetics and breeding. In this research, public RNA-seq data and the annotated reference genome were used to identify the genes in lotus. A total of 26,819 consensus and 1,081 novel genes were identified. Meanwhile, a comprehensive analysis of gene alternative splicing events was conducted, and a total of 19,983 “internal” alternative splicing (AS) events and 14,070 “complete” AS events were detected in… More >

Dumitru Baleanu^1,2,3, Ahmad Sami Al-Shamayleh⁴, Rabha W. Ibrahim^5,*

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 3465-3477, 2023, DOI:10.32604/cmc.2023.037162 - 31 March 2023

Abstract Image forgery is a crucial part of the transmission of misinformation, which may be illegal in some jurisdictions. The powerful image editing software has made it nearly impossible to detect altered images with the naked eye. Images must be protected against attempts to manipulate them. Image authentication methods have gained popularity because of their use in multimedia and multimedia networking applications. Attempts were made to address the consequences of image forgeries by creating algorithms for identifying altered images. Because image tampering detection targets processing techniques such as object removal or addition, identifying altered images remains… More >

Liang Xiu-jian^1,2,*, Sun He²

Journal of Cyber Security, Vol.4, No.2, pp. 119-133, 2022, DOI:10.32604/jcs.2022.032915 - 04 July 2022

Abstract Increasingly advanced image processing technology has made digital image editing easier and easier. With image processing software at one’s fingertips, one can easily alter the content of an image, and the altered image is so realistic that it is illegible to the naked eye. These tampered images have posed a serious threat to personal privacy, social order, and national security. Therefore, detecting and locating tampered areas in images has important practical significance, and has become an important research topic in the field of multimedia information security. In recent years, deep learning technology has been widely… More >