JIAWEI FU^1,2,3,#, CHUNSHUAI WU^1,2,3,#, GUANHUA XU^1,2,3, JINLONG ZHANG¹, YIQIU LI¹, CHUNYAN JI^1,2,3, ZHIMING CUI^1,2,3,*

BIOCELL, Vol.47, No.4, pp. 739-749, 2023, DOI:10.32604/biocell.2023.026881 - 08 March 2023

Abstract Spinal cord injury (SCI), a complex neurological disorder, triggers a series of devastating neuropathological events such as ischemia, oxidative stress, inflammatory events, neuronal apoptosis, and motor dysfunction. However, the classical necrosome, which consists of receptor-interacting protein (RIP)1, RIP3, and mixed-lineage kinase domain-like protein, is believed to control a novel type of programmed cell death called necroptosis, through tumour necrosis factor-alpha/tumour necrosis factor receptor-1 signalling or other stimuli. Several studies reported that necroptosis plays an important role in neural cell damage, release of intracellular pro-inflammatory factors, lysosomal dysfunction and endoplasmic reticulum stress. Recent research indicates that More >

Joddat Fatima^1,*, Amina Jameel², Muhammad Usman Akram³, Adeel Muzaffar Syed¹, Malaika Mushtaq³

Intelligent Automation & Soft Computing, Vol.34, No.3, pp. 1489-1504, 2022, DOI:10.32604/iasc.2022.025935 - 25 May 2022

Abstract The long twisted fragile tube, termed as spinal cord, can be named as the second vital organ of Central Nervous System (CNS), after brain. In human anatomy, all crucial life activities are controlled by CNS. The spinal cord does not only control the flow of information from the brain to rest of the body, but also takes charge of our reflexes control and the mobility of body. It keeps the body upright and acts as the main support for the flesh and bones. Spine deformity can occur by birth, due to aging, injury or spine… More >

XUYI WANG¹, WEN ZHANG², LEI GAO², KUANXIN LI^1,3,*

BIOCELL, Vol.46, No.9, pp. 2065-2072, 2022, DOI:10.32604/biocell.2022.018265 - 18 May 2022

Abstract Background: Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system, and there is currently no effective treatment for SCI because of its complicated pathophysiology. Bone marrow mesenchymal stem cells (BMSCs) have multidirectional differentiation abilities. Our study aims to explore the effects of bone morphogenetic protein 7 (BMP-7)-modified BMSCs transplantation on the repair of SCI in rats. Methods: In this study, a rat spinal cord injury model was established with the modified Allen method. Then, BMSCs transfected with the BMP7 gene were transplanted to treat the spinal cord injury in rats. Forty… More >

Min Rao¹, Yufeng Li^1,*, Hongye Liu², Isabel Wang³, Yongjun Ren⁴

Intelligent Automation & Soft Computing, Vol.34, No.1, pp. 455-466, 2022, DOI:10.32604/iasc.2022.027694 - 15 April 2022

Abstract The aim of spinal cord injury rehabilitation is to increase the independent ability of patients, so that patients can return to society and live a creative life. Regaining independence living is the primary goal of rehabilitation. Rehabilitation of patients with spinal cord injury is a long and lengthy process, which needs comprehensive dimensions support from medical workers, family members, and social support. At present, medical institutions and researchers mainly focus on the level of physical recovery and the treatment of complications in patients with spinal cord injury and pay less attention to social factors during… More >

JINGJIE LIU^1,#, XIAOYAN DING^2,#, LI XIANG¹, SHENGLI HUANG^3,*

BIOCELL, Vol.46, No.6, pp. 1537-1544, 2022, DOI:10.32604/biocell.2022.018441 - 07 February 2022

Abstract This study aimed to evaluate the integration of transplanted choroidal plexus epithelial cells with organotypic spinal cord slices. Organotypic spinal cord slices, normally cultured for 6 days, were divided into control group (Ctrl) and transplanted group (T). The choroidal plexus epithelial cells were dissociated and primary cultured (C group). The choroidal plexus epithelial cells cultured for 6–7 days were labeled by 1,1’-dioctadecyl-3,3,3’,3’-tetramethyl-indocarbocyanineperchlorate (CM-Dil), and were identified by transthyretin (TTR) in immunocytochemistry. They were adjusted to the density of 0.5–1 × 10⁷/ml, then 2 μl cells suspension were transplanted to the spinal cord slices in the T… More >

XINFU FAN^1,2,#, JIE CHEN^3,#, ZONGMENG ZHANG^4,#, FANGHUI CHEN⁵, HAOSEN WANG⁶, YAFEI CAI⁶, JUN LI^7,*

BIOCELL, Vol.46, No.6, pp. 1527-1535, 2022, DOI:10.32604/biocell.2022.018269 - 07 February 2022

Abstract Spinal cord injury (SCI) remains an intractable clinical challenge of neurosurgery, it can be divided into two stages: uncontrollable primary injury induced by mechanical damage and controllable secondary injury regulated by continuous cell death. The apoptosis was the one of most important events in secondary injury, previous studies revealed that excessive endoplasmic reticulum (ER) stress breaks down the homeostasis and triggers apoptosis in the spinal cord. To deter or alleviate the secondary jury, we screen one of fat-soluble compounds, salubrinal, which was an inhibitor of eIF2α dephosphorylation can repair SCI by inhibiting ER stress in… More >

RAMSHA SHAMS^1,2, NAREN L. BANIK^1,2,3,*, AZIZUL HAQUE^1,*

BIOCELL, Vol.45, No.6, pp. 1453-1457, 2021, DOI:10.32604/biocell.2021.017659 - 01 September 2021

Abstract Spinal Cord Injury (SCI) is a debilitating condition characterized by damage to the spinal cord, resulting in loss of function, mobility, and sensation. Although increasingly prevalent in the US, no FDA-approved therapy exists due to the unfortunate complexity of the condition, and the difficulties of SCI may be furthered by the development of SCI-related complications, such as osteoporosis. SCI demonstrates two crucial stages for consideration: the primary stage and the secondary stage. While the primary stage is suggested to be immediate and irreversible, the secondary stage is proposed as a promising window of opportunity for… More >