Ping Zhao*, Hai-Tao Guan†, Zhi-Jun Dai†, Yu-Guang Ma†, Xiao-Xu Liu†, Xi-Jing Wang†
Oncology Research, Vol.24, No.6, pp. 437-445, 2016, DOI:10.3727/096504016X14685034103554
Abstract Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan (testican) 1 (SPOCK1), known as testican-1,
were found to be involved in the development and progression of tumors. However, in colorectal cancer (CRC),
the expression pattern of SPOCK1 and its functional role remain poorly investigated. In the present study,
we explored the role of SPOCK1 in CRC. Our results demonstrated that SPOCK1 is overexpressed in CRC
cell lines. SPOCK1 silencing significantly inhibited the proliferation in vitro and the tumor growth in vivo.
Furthermore, SPOCK1 silencing significantly attenuated the migration/invasion by reversing the EMT process
in CRC cells. Finally, knockdown More >
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