GUIBIN ZHONG1,2,#, SHURONG WANG3,#, YUJIN HE4, DAMING FENG1, KE WEI1, YANQIU YANG1, JIANWEI CHEN1,2,*, JUNLING CHEN1,*
BIOCELL, Vol.48, No.6, pp. 1001-1008, 2024, DOI:10.32604/biocell.2024.050294
Abstract Background: Hypertrophy of the ligamentum flavum (HLF) is a common contributor to spinal stenosis which results in significant neurological impairments. Circular RNA (circRNA) circ_0003609 has been linked to HLF; however, the exact mechanism by which it causes this disease is unclear. Methods: Circ_0003609 expressions were regulated in HLF cells by overexpression vectors and RNA interference. Cell proliferation and fibrosis-related gene expression were checked by the Cell Counting Kit-8 (CCK-8) assay and western blotting. CircBank’s prediction of the association between miR-155 and circ_0003609 was supported by a dual-luciferase reporter experiment. The function of the miR-155/sirtuin 1 More >
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