Liying Gong1,2,3, Hongkun Jiang4, Guangrong Qiu1, Kailai Sun1,*
Congenital Heart Disease, Vol.16, No.5, pp. 499-512, 2021, DOI:10.32604/CHD.2021.015831
- 03 June 2021
Abstract Background: microRNAs are crucial for cardiovascular development and are associated with congenital heart disease (CHD). Recent studies have shown that microRNAs play a role in heart development and is closely related to
CHD. The present study investigated the underlying mechanism of microRNA-208a (miR-208a) in “simple”
CHD. Material and Methods: Reverse transcription-quantitative PCR (RT-qPCR) demonstrated miR-208a
expression levels in children with CHD (n = 27) compared with normal controls (n = 29), in cardiomyocytes from
embryo 10 (E10) to post-birth (P7) and organs in adult rats in healthy rats. Apoptosis of H9c2 cells after transfection with miR-208a detected… More >
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