Wen-Shou Tan^1,#, Hsuan Kuo^2,#, Chang-Ge Jiang¹, Mei-Han Lu¹, Yi-He Lu¹, Yung-Li Wang¹, Ching-Shuen Wang¹, Thi Thuy Tien Vo³, I-Ta Lee^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070871 - 30 December 2025

Abstract This narrative review examines recent advances in salivary biomarkers for oral squamous cell carcinoma (OSCC), a major subtype of oral cancer with persistently low five-year survival rates due to delayed diagnosis. Saliva has emerged as a noninvasive diagnostic medium capable of reflecting both local tumor activity and systemic physiological changes. Various salivary biomarkers, including microRNAs, cytokines, proteins, metabolites, and exosomes, have been linked to oncogenic signaling pathways involved in tumor progression, immune modulation, and therapeutic resistance. Advances in quantitative polymerase chain reaction, mass spectrometry, and next-generation sequencing have enabled comprehensive biomarker profiling, while point-of-care detection More >

Malini Ray¹, Sanchari Burman², Shweta Meshram^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2285-2312, 2025, DOI:10.32604/phyton.2025.067814 - 29 August 2025

Abstract Plants are under constant exposure to varied biotic and abiotic stresses, which significantly affect their growth, productivity, and survival. Biotic stress, caused by pathogens, and abiotic stress, including drought, salinity, extreme temperatures, and heavy metals, activate overlapping yet distinct immune pathways. These are comprised of morphological barriers, hormonal signaling, and the induction of stress-responsive genes through complex pathways mediated by reactive oxygen species (ROS), phytohormones, and secondary metabolites. Abiotic stress triggers organelle-mediated retrograde signaling from organelles like chloroplasts and mitochondria, which causes unfolded protein responses and the regulation of cellular homeostasis. Simultaneously, biotic stress activates… More > Graphic Abstract

FANG CHEN¹, DONGQIANG YANG², YUHUA RU³, SHAN CAO¹, AISHE GAO¹

Oncology Research, Vol.33, No.7, pp. 1799-1800, 2025, DOI:10.32604/or.2025.064363 - 26 June 2025

Abstract This article has no abstract. More >

Chang Wang^1,2,#, Zhi Zhang^1,#, Wei Sun¹, Quan Quan³, Wenshuang Hou³, Chenghao Jin^1,3,4,*

BIOCELL, Vol.49, No.3, pp. 465-482, 2025, DOI:10.32604/biocell.2025.062155 - 31 March 2025

Abstract Objectives: Epibrassinolide (EBR) is a steroid hormone with anti-tumor properties. Nevertheless, its potential to inhibit gastric cancer (GC) cells remains unknown. The aim of this research was to examine the effects of EBR on GC cells and to investigate the specific mechanism of EBR. Methods: A cell counting kit-8 (CCK-8) assay was utilized to determine cell survival rates. The investigation of apoptosis, cell cycle progression, and reactive oxygen species (ROS) levels was performed using flow cytometry. To detect cell migration, a wound-healing assay was performed on AGS cells. Furthermore, western blotting assay was utilized to determine… More >

Long Qi¹, Chaoran Wu¹, Hao Sun^1,2,*, Hong Liao^1,*

BIOCELL, Vol.49, No.2, pp. 167-180, 2025, DOI:10.32604/biocell.2025.059159 - 28 February 2025

Abstract Glutamate is an essential excitatory neurotransmitter in the brain, playing a vital role in regulating synaptic activity and maintaining the homeostasis of the cerebral environment but also serves as a central hub for neuronal injury and inflammatory responses. In various pathological conditions, such as ischemic stroke, glutamate is released and accumulates excessively in the brain, leading to heightened stimulation of neurons and excitotoxicity. This phenomenon positions glutamate as a primary inducing factor for neuronal damage following cerebral ischemia. Glutamate exerts its effects primarily through two types of receptors: ionotropic and metabotropic glutamate receptors, both of… More >

PINGHUA TU, SHANSHAN WANG, KELAN DENG, XINJUN LI, ZHANLING WU^*

BIOCELL, Vol.48, No.11, pp. 1603-1612, 2024, DOI:10.32604/biocell.2024.054364 - 07 November 2024

Abstract Objectives: The antitumor effects of pyropheophorbide-α methyl ester-mediated photodynamic therapy (MPPa-PDT) were observed in several cancers. The objective of this investigation was to examine the antineoplastic efficacy of MPPa-PDT acting on lung carcinoma A549 cells and further elaborate mechanisms. Methods: The viability of A549 cells was examined with cell counting kit-8 after MPPa-PDT disposal. Hoechst 33342 staining, monodansylcadaverine (MDC) staining, and transmission electron microscopy were employed to observe apoptotic bodies and autophagic vesicles. Flow cytometry with Annexin V/propidium iodide (PI) labeling objectively assessed cell death. The expression of associated proteins, including Caspase-3, Beclin-1, LC-3II, and More > Graphic Abstract

YAN-NAN LI^1,#, YUN-HONG XIU^2,#, YAN-JUN TANG³, JING-LONG CAO¹, WEN-SHUANG HOU¹, AN-QI WANG¹, TIAN-ZHU LI^4,*, CHENG-HAO JIN^1,3,5,*

BIOCELL, Vol.48, No.7, pp. 1055-1069, 2024, DOI:10.32604/biocell.2024.050515 - 03 July 2024

Abstract Objectives: Sciadopitysin (SP) is a flavonoid in Ginkgo biloba that exhibits various pharmacological activities. This study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma (HCC) cells. Methods: Network pharmacology was used for target prediction analysis. Cell Counting Kit-8 (CCK-8) assay was used to test the cell viability. Flow cytometry was used to test the cell cycle distribution, apoptosis status, and reactive oxygen species (ROS) levels. Transwell and wound-healing assay was used to test the migration effect of SP on HepG2 cells. Western Blot assay was used to… More > Graphic Abstract

MOHD ATHAR^1,*, ANU MANHAS², NISARG RANA², AHMAD IRFAN³

BIOCELL, Vol.48, No.6, pp. 935-944, 2024, DOI:10.32604/biocell.2024.049891 - 10 June 2024

Abstract Computational methods have significantly transformed biomedical research, offering a comprehensive exploration of disease mechanisms and molecular protein functions. This article reviews a spectrum of computational tools and network analysis databases that play a crucial role in identifying potential interactions and signaling networks contributing to the onset of disease states. The utilization of protein/gene interaction and genetic variation databases, coupled with pathway analysis can facilitate the identification of potential drug targets. By bridging the gap between molecular-level information and disease understanding, this review contributes insights into the impactful utilization of computational methods, paving the way for More >

JINGLONG CAO^1,#, SHUMEI LI^2,#, TONG ZHANG^1,#, JIAN LIU¹, WENSHUANG HOU¹, ANQI WANG¹, CHANG WANG^3,4,*, CHENGHAO JIN^1,3,5,*

BIOCELL, Vol.48, No.2, pp. 313-325, 2024, DOI:10.32604/biocell.2023.043474 - 23 February 2024

Abstract Background: Valtrate (Val) was extracted from the Valeriana jatamansi Jones plant, had good antitumor activity. However, its precise molecular mechanism in cancer cells was still unclear. This study investigated the effect of Val on gastric cancer (GC) cells and its potential molecular mechanism. Methods: Cell viability was examined by CCK-8 assay. Cell cycle, apoptosis, and Reactive oxygen species (ROS) level were analyzed by flow cytometry. The migration effect of Val on AGS cells was analyzed by transwell and wound-healing assay. The expression levels of proteins were analyzed by western blot. Results: The cell viability assay results demonstrated… More > Graphic Abstract

JIA LIU^1,2,#, FAPING WANG^1,2,#, BO YUAN³, FENGMING LUO^1,2,*

BIOCELL, Vol.47, No.4, pp. 697-705, 2023, DOI:10.32604/biocell.2023.026148 - 08 March 2023

Abstract Runt-related transcription factor-1 (RUNX1), also known as the core-binding factor alpha 2 subunit, is closely related to human leukemia. The functions of RUNX1 in modulating cell proliferation, differentiation, and survival in multiple systems have been gradually discovered with the emergence of transgenic mice. RUNX1 is a powerful transcription factor implicated in diverse signaling pathways and cellular mechanisms that participate in lung development and pulmonary diseases. RUNX1 has recently been identified as a target regulator of fibrotic remodeling diseases, particularly in the kidney. However, the role of RUNX1 in pulmonary fibrosis is unclear. Pulmonary fibrosis is More >