Erkun Guo, Hongjiang Liu, Xiaopeng Liu
Oncology Research, Vol.25, No.3, pp. 437-444, 2017, DOI:10.3727/096504016X14747335734344
Abstract Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the SCUBE family of
proteins, was recently found to play an important role in cancer development. However, little is known regarding its biological function in glioma. In the present study, we investigated the effect of SCUBE2 on glioma and
explored its relevant mechanisms. The study showed that SCUBE2 had a low expression in glioma tissue and
cell lines. SCUBE2 overexpression inhibited glioma cell proliferation in vitro and in vivo as well as suppressed
glioma cell migration and invasion in vitro. Furthermore, we found that More >
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