Vinitha Richard, Rajesh Raju, Aswathy Mary Paul, Reshmi Girijadevi, Thankayyan Retnabai Santhosh Kumar, Madhavan Radhakrishna Pillai
Oncology Research, Vol.26, No.1, pp. 17-26, 2018, DOI:10.3727/096504017X14881490607028
Abstract This study is an integrated analysis of the transcriptome profile microRNA (miRNA) and its experimentally
validated mRNA targets differentially expressed in the tumorigenic stem-like fraction of oral squamous cell
carcinoma (OSCC). We had previously reported the coexistence of multiple drug-resistant tumorigenic fractions, termed side population (SP1, SP2, and MP2), and a nontumorigenic fraction, termed main population
(MP1), in oral cancer. These fractions displayed a self-renewal, regenerative potential and expressed known
stemness-related cell surface markers despite functional differences. Flow cytometrically sorted pure fractions
of SP1 and MP1 cells were subjected to differential expression analysis of both… More >
Login
Register
