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  • Open Access

    ARTICLE

    Exploring the Prevalence and Contributing Factors of Depression among Sickle Cell Anemia Patients in Saudi Arabia’s Jazan Region

    Abdullah A. Alharbi1, Ahmad Y. Alqassim1,*, Mohammed A. Muaddi1, Najat H. Aldubayyan1, Rana I. Abuhadi1, Futon A. Akoor1, Sarah J. Mobarki1, Imtenan A. Oberi1, Ghaidaa H. Alharbi1, Yara Ajeebi1, Adnan M. Alkhayat2, Hafiz Malhan3, Mohammed Bakkar4, Anwar M. Makeen1

    International Journal of Mental Health Promotion, Vol.26, No.5, pp. 351-359, 2024, DOI:10.32604/ijmhp.2024.047219 - 30 May 2024

    Abstract Sickle Cell Anemia (SCA) is a prevalent genetic condition in Saudi Arabia, particularly in the Jazan region. The study’s purpose was to assess the prevalence of de-pression among individuals with SCA in this area and to identify the factors associated with this condition. The study involved 391 adult participants, all patients in the hematology center of Prince Mohammed bin Nasser Hospital (PMNH). Data was collected through an anonymous interview questionnaire–the Arabic version of the Patient Health Questionnaire-9 (PHQ-9)–between March–May 2022. The questionnaire covered socio-demographic information and variables related to the participant’s SCA history, such as… More >

  • Open Access

    ARTICLE

    Altered levels of pro-inflammatory cytokines in sickle cell disease patients during vaso-occlusive crises and the steady state condition

    Bijan Keikhaei1, Ali Reza Mohseni2, Reza Norouzirad3, Mastaneh Alinejadi4, Somayeh Ghanbari1, Fariba Shiravi1, Ghasem Solgi5

    European Cytokine Network, Vol.24, No.1, pp. 45-52, 2013, DOI:10.1684/ecn.2013.0328

    Abstract Objective: This study aimed to evaluate serum levels of pro-inflammatory cytokines and TGF-β in sickle cell disease (SCD) patients, and to compare the results during vaso-occlusive crisis (VOC) or steady state (StSt) conditions. Methods: 54 SCD patients (37HbSS and 17Sβ+Thal) were enrolled in the study and evaluated in two groups as follows; group A consisted of 39 VOC patients and group B comprised 15 StSt patients. Nineteen healthy volunteers were included as controls. Circulating levels of IL-1, IL-6, IL-8, IL-17,TNF-α and TGF-β were measured using ELISA. Results: Patients in VOC showed higher mean levels of all… More >

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