Amanda Ikegami*, Luiz Felipe S. Teixeira*, Marina S. Braga†, Matheus Henrique Dos S. Dias‡, Eduardo C. Lopes‡, Maria Helena Bellini*
Oncology Research, Vol.26, No.5, pp. 743-751, 2018, DOI:10.3727/096504017X15120379906339
Abstract Renal cell carcinoma (RCC) accounts for approximately 2%–3% of human malignancies and is the most aggressive among urologic tumors. Biological heterogeneity, drug resistance, and chemotherapy side effects are the
biggest obstacles to the effective treatment of RCC. The NF-kB transcription factor is one of several molecules
identified to be responsible for the aggressive phenotype of this tumor. In the past decade, several studies have
demonstrated the activation of NF-kB in RCC, and many have implicated NF-kB1 (p50) as an important molecule in tumor progression and metastasis. In the present study, a lentivirus was used to… More >
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