Xiaoyu Wu*1, Jin Zhou†1, Zhenfeng Wu*, Che Chen*, Jiayun Liu*, Guannan Wu*, Jing Zhai*, Fukun Liu*, Gang Li‡
Oncology Research, Vol.25, No.8, pp. 1383-1390, 2017, DOI:10.3727/096504017X14879366402279
Abstract miR-101-3p has been identified as a tumor suppressor in several cancers, but its exact role in gastric adenocarcinoma is still largely unknown. In this study, we found that, compared with the RGM-1 human normal
gastric epithelial cells, miR-101-3p was significantly downregulated in all six human gastric adenocarcinoma
cell lines, including BGC-823, MNK-45, MGC-803, SGC-7901, AGS, and HGC-27. Overexpression of miR-
101-3p suppressed both the proliferation and invasion of AGS gastric adenocarcinoma cells, and knockdown
of miR-101-3p displayed the opposite effect. In addition, miR-101-3p could directly target and suppress
the expression of the serum response factor More >
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