YANSHUANG ZHAO, WANXI YANG^*

BIOCELL, Vol.47, No.8, pp. 1709-1725, 2023, DOI:10.32604/biocell.2023.030379 - 28 August 2023

Abstract The phosphoinositide-3-kinase/Akt (PI3K/AKT) signaling pathway is crucial for Sertoli cell development and completing spermatogenesis. Its main role is to promote proliferation and inhibit apoptosis. Many factors activate the PI3K/AKT pathway, like hormones, such as follicle stimulating hormone (FSH), androgen, estrogen, insulin to name a few. Many of these factors have receptors inside or on the surface of Sertoli cells (SCs). This review summarizes how these hormones directly regulate the PI3K/AKT signaling pathway in SCs, which in turn affects SC proliferation and differentiation. Further, hormone-mediated PI3K/AKT signaling also stimulates SC secretion, which is essential for germ More >

CHEN WANG, CHAOFAN HE, YUANYUAN GAO, KAIXIAN WANG, MENG LIANG^*

BIOCELL, Vol.47, No.1, pp. 155-164, 2023, DOI:10.32604/biocell.2023.024657 - 26 September 2022

Abstract Heat stress is an important influence on the male reproductive organs. Therefore, the effects of heat stress on genes or pathways related to the reproductive system of male mice were experimentally explored in this paper to further determine the effects of heat stimulation on mammals. Herein, models of heat-exposed mouse testicular tissue and heat-excited cells were successfully established. Many scorched vesicles were found after heat excitation of testis supporting cells, testicular mesenchymal (TM4) cells. Western blot, in situ terminal deoxynucleotide transferase dUTP Nick end labeling (TUNEL) and transmission electron microscopy showed that membrane rupture, mitochondrial damage More >